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Evolutionary history, genomic adaptation to toxic diet, and extinction of the Carolina Parakeet

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dc.contributor.author Gelabert Xirinachs, Pere, 1991-
dc.contributor.author Serres Armero, Aitor, 1992-
dc.contributor.author de Manuel, Marc
dc.contributor.author Renom, Pere
dc.contributor.author de Dios, Toni
dc.contributor.author Ferrando-Bernal, Manuel, 1990-
dc.contributor.author Navarro i Cuartiellas, Arcadi, 1969-
dc.contributor.author Marquès i Bonet, Tomàs, 1975-
dc.contributor.author Lalueza Fox, Carles, 1965-
dc.date.accessioned 2020-03-17T09:03:26Z
dc.date.available 2020-03-17T09:03:26Z
dc.date.issued 2020
dc.identifier.citation Gelabert P, Sandoval-Velasco M, Serres A, de Manuel M, Renom P, Margaryan A et al. Evolutionary history, genomic adaptation to toxic diet, and extinction of the Carolina Parakeet. Curr Biol. 2020 Jan 6; 30(1): 108-114.e5. DOI: 10.1016/j.cub.2019.10.066
dc.identifier.issn 0960-9822
dc.identifier.uri http://hdl.handle.net/10230/43920
dc.description.abstract As the only endemic neotropical parrot to have recently lived in the northern hemisphere, the Carolina parakeet (Conuropsis carolinensis) was an iconic North American bird. The last surviving specimen died in the Cincinnati Zoo in 1918 [1]. The cause of its extinction remains contentious: besides excessive mortality associated to habitat destruction and active hunting, their survival could have been negatively affected by its range having become increasingly patchy [2] or by the exposure to poultry pathogens [3, 4]. In addition, the Carolina parakeet showed a predilection for cockleburs, an herbaceous plant that contains a powerful toxin, carboxyatractyloside, or CAT [5], which did not seem to affect them but made the birds notoriously toxic to most predators [3]. To explore the demographic history of this bird, we generated the complete genomic sequence of a preserved specimen held in a private collection in Espinelves (Girona, Spain), as well as of a close extant relative, Aratinga solstitialis. We identified two non-synonymous genetic changes in two highly conserved proteins known to interact with CAT that could underlie a specific dietary adaptation to this toxin. Our genomic analyses did not reveal evidence of a dramatic past demographic decline in the Carolina parakeet; also, its genome did not exhibit the long runs of homozygosity that are signals of recent inbreeding and are typically found in endangered species. As such, our results suggest its extinction was an abrupt process and thus likely solely attributable to human causes.
dc.description.sponsorship This work was supported by ERC Consolidator Grant 681396 “Extinction Genomics” to M.T.P.G. and M.S.-V., Obra Social ‘‘La Caixa’’ and Secretaria d’Universitats i Recerca (GRC2017-SGR880) to T.M.-B. and C.L.-F., BFU2017-86471-P and PGC2018-101927-B-I00 from MINECO/FEDER, UE to T.M.-B, and PGC2018-095931-B-100 from MINECO/FEDER, UE to C.L.-F. T.M.-B. is also supported by a U01 MH106874 grant and Howard Hughes International Early Career and CERCA Programme (Generalitat de Catalunya). A.A. is partially supported by the Strategic Funding UID/Multi/04423/2019 through national funds provided by the Portuguese Foundation for Science and Technology (FCT) and the European Regional Development Fund—program PT2020, by the European Structural and Investment Funds—Competitiveness and Internationalization Operational Program-COMPETE 2020, and by National Funds through the FCT under the project PTDC/CTA-AMB/31774/2017(POCI-01-0145-FEDER/031774/2017)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Current Biology. 2020 Jan 6; 30(1): 108-114.e5
dc.rights © 2019 Pere Gelabert et al. Published by Elsevier Ltd. This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Genòmica
dc.subject.other Extinció (Biologia)
dc.subject.other Ornitologia
dc.subject.other Genètica de poblacions
dc.subject.other Alimentació
dc.title Evolutionary history, genomic adaptation to toxic diet, and extinction of the Carolina Parakeet
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.cub.2019.10.066
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/681396
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/BFU2017-86471-P
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-101927-B-I00
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PGC2018-095931-B-100
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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