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Predictive factors of renal impairment in HIV-infected patients on antiretroviral therapy: results From the VACH longitudinal cohort study

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dc.contributor.author Domingo, Pere
dc.contributor.author Suarez-Lozano, Ignacio
dc.contributor.author Gutiérrez, Félix
dc.contributor.author Estrada, Vicente
dc.contributor.author Knobel Freud, Hernando
dc.contributor.author Palacios, Rosario
dc.contributor.author Antela, Antonio
dc.contributor.author Blanco, José-Ramón
dc.contributor.author Fulladosa, Xavier
dc.contributor.author VACH
dc.date.accessioned 2020-03-05T08:24:55Z
dc.date.available 2020-03-05T08:24:55Z
dc.date.issued 2019
dc.identifier.citation Domingo P, Suarez-Lozano I, Gutierrez F, Estrada V, Knobel H, Palacios R. et al. Predictive factors of renal impairment in HIV-infected patients on antiretroviral therapy: Results from the VACH longitudinal cohort study. Nefrologia. 2019 Sep-Oct;39 (5):497-505. DOI: 10.1016/j.nefro.2019.01.009
dc.identifier.issn 0211-6995
dc.identifier.uri http://hdl.handle.net/10230/43803
dc.description.abstract Background: The use of combination antiretroviral therapy has led to dramatic improvements in the life expectancy of HIV-infected persons. As result, the HIV population is aging and increasingly facing illnesses typically seen in the elderly, such as chronic kidney disease (CKD). Methods: A retrospective longitudinal study was conducted using data from years 2010 and 2014 in all HIV-infected persons enrolled at the Spanish VACH cohort. We analyzed the prevalence and the predictive factors for developing CKD (estimated glomerular filtration rate, eGFR<60mL/min/1.73m2). Results: The CKD prevalence at baseline was 456/8968, 5.1% [4.6-5.6%]. Of 8512 HIV-positive individuals examined without CKD at baseline (73.7% male, median age 44 years-old), 2.15% developed CKD (eGFR<60mL/min/1.73m2). The odds ratios [95%CI] for the independent predictive factors identified were gender (male) 0.54 [0.39-0.75], age (per year) 1.08 [1.07-1.10], AIDS diagnosis 1.40 [1.03-1.91], protease inhibitor-based regimens 1.49 [1.10-2.02], hypertension 1.37 [0.94-1.99], diabetes 1.84 [1.33-2.55] and history of cardiovascular events 1.66 [0.96-2.86]. Conclusion: The prevalence and risk factors for CKD and its progression are high in the VACH cohort. Thus, preventive measures such as control of hypertension, diabetes and obesity, as well as efforts for avoiding exposure to nephrotoxic drugs, including some antiretrovirals, are warranted in this aging HIV population.
dc.format.mimetype application/pdf
dc.language.iso spa
dc.language.iso eng
dc.publisher Elsevier
dc.rights 0211-6995/© 2019 Sociedad Española de Nefrología. Published by Elsevier España, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Predictive factors of renal impairment in HIV-infected patients on antiretroviral therapy: results From the VACH longitudinal cohort study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.nefro.2019.01.009
dc.subject.keyword Ageing
dc.subject.keyword Diabetes
dc.subject.keyword Disfunción renal
dc.subject.keyword Envejecimiento
dc.subject.keyword España
dc.subject.keyword Fumarato de disoproxilo de tenofovir
dc.subject.keyword Hipertensión
dc.subject.keyword Human immunodeficiency virus
dc.subject.keyword Hypertension
dc.subject.keyword Insuficiencia renal
dc.subject.keyword Renal impairment
dc.subject.keyword Renal insufficiency
dc.subject.keyword Spain
dc.subject.keyword Tenofovir
dc.subject.keyword Tenofovir disoproxil fumarate
dc.subject.keyword Virus de la inmunodeficiencia humana
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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