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Brain structure and function in school-aged children with sluggish cognitive tempo symptoms

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dc.contributor.author Camprodon-Rosanas, Ester
dc.contributor.author Pujol Martí, Jesús, 1981-
dc.contributor.author Martínez-Vilavella, Gerard
dc.contributor.author Blanco Hinojo, Laura, 1981-
dc.contributor.author Medrano-Martorell, Santiago
dc.contributor.author Batlle, Santiago
dc.contributor.author Forns i Guzman, Joan, 1981-
dc.contributor.author Ribas Fitó, Núria
dc.contributor.author Dolz, Montserrat
dc.contributor.author Sunyer Deu, Jordi
dc.date.accessioned 2020-02-26T09:16:09Z
dc.date.available 2020-02-26T09:16:09Z
dc.date.issued 2019
dc.identifier.citation Camprodon-Rosanas E, Pujol J, Martínez-Vilavella G, Blanco-Hinojo L, Medrano-Martorell S, Batlle S et al. Brain structure and function in school-aged children with sluggish cognitive tempo symptoms. J Am Acad Child Adolesc Psychiatry. 2019;58(2):256-66. DOI: 10.1016/j.jaac.2018.09.441
dc.identifier.issn 0890-8567
dc.identifier.uri http://hdl.handle.net/10230/43715
dc.description.abstract Objective: Sluggish cognitive tempo (SCT) is a cluster of symptoms associated with poor function in various domains of major life activities that may comprise a novel attention disorder distinct from attention-deficit/hyperactivity disorder (ADHD). Nevertheless, very little is known about the neural substrate of SCT in children. The present study aimed to examine associations between SCT symptoms and brain structure and function in school-aged children. Method: We performed a cross-sectional MRI study in 178 children 8 to 12 years old from primary schools in Barcelona, Spain. Data were collected between January 2012 and March 2013. Parents completed the Sluggish Cognitive Tempo-Child Behavior Checklist (SCT-CBCL). Participants underwent magnetic resonance imaging to assess regional brain volume, white matter integrity using diffusion tensor imaging, and functional connectivity in major neural networks. Results: SCT symptoms were associated with altered anatomy of the frontal lobe in the form of increased regional volume. The anomalously large cortical regions were less mature in terms of functional connectivity. Importantly, all the anatomical and functional anomalies identified remained significant after adjusting the analyses for ADHD symptom scores. Conclusion: Our results suggest that SCT symptoms are associated with distinct features of brain structure and function that differ from the classical neural substrates described in ADHD.
dc.description.sponsorship This work was supported by the European Research Council under the ERC (grant number 268479)—the BREATHE project. The Agency of University and Research Funding Management of the Catalonia Government part icipated in the context of Research Group SGR2014-167
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Journal of the American Academy of Child and Adolescent Psychiatry. 2019;58(2):256-66
dc.rights © Elsevier http://dx.doi.org/10.1016/j.jaac.2018.09.441
dc.title Brain structure and function in school-aged children with sluggish cognitive tempo symptoms
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.jaac.2018.09.441
dc.subject.keyword Attention-deficit hyperactivity disorder
dc.subject.keyword Executive function
dc.subject.keyword FMRI
dc.subject.keyword School-age children
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/268479
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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