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Incidence of cardiovascular disease in patients with familial hypercholesterolemia phenotype: analysis of 5 years follow-up of real-world data from more than 1.5 million patients

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dc.contributor.author Masana, Luís
dc.contributor.author Zamora, Alberto
dc.contributor.author Plana, Nuria
dc.contributor.author Comas Cufí, Marc
dc.contributor.author Garcıa-Gil, Maria
dc.contributor.author Martí, Ruth
dc.contributor.author Ponjoan, Anna
dc.contributor.author Alves-Cabratosa, Lia
dc.contributor.author Elosua Llanos, Roberto
dc.contributor.author Marrugat de la Iglesia, Jaume
dc.contributor.author Dégano, Irene R.
dc.contributor.author Ramos, Rafel
dc.date.accessioned 2020-02-10T08:22:29Z
dc.date.available 2020-02-10T08:22:29Z
dc.date.issued 2019
dc.identifier.citation Masana L, Zamora A, Plana N, Comas-Cufí M, Garcia-Gil M, Martí R.et al. Incidence of cardiovascular disease in patients with familial hypercholesterolemia phenotype: analysis of 5 years follow-up of real-world data from more than 1.5 million patients. J Clin Med. 2019 Jul 23;8(7):1080. DOI: 10.3390/jcm8071080
dc.identifier.issn 2077-0383
dc.identifier.uri http://hdl.handle.net/10230/43533
dc.description.abstract In the statin era, the incidence of atherosclerotic cardiovascular diseases (ASCVD) in patients with familial hypercholesterolemia (FH) has not been updated. We aimed to determine the incidence of ASCVD in patients with FH-phenotype (FH-P) and to compare it with that of normal low-density lipoprotein cholesterol (LDL-C) patients. We performed a retrospective cohort study using the Database of the Catalan primary care system, including ≥18-year-old patients with an LDL-C measurement. From 1,589,264 patients available before 2009, 12,823 fulfilled FH-P criteria and 514,176 patients were normolipidemic (LDL-C < 115 mg/dL). In primary prevention, patients with FH-P had incidences of ASCVD and coronary heart disease (CHD) of 14.9/1000 and 5.8/1000 person-years, respectively, compared to 7.1/1000 and 2.1/1000 person-years in the normolipidemic group. FH-P showed hazard ratio (HR) of 7.1 and 16.7 for ASCVD and CHD, respectively, in patients younger than 35 years. In secondary prevention, patients with FH-P had incidences of ASCVD and CHD of 89.7/1000 and 34.5/1000 person-years, respectively, compared to 90.9/1000 and 28.2/1000 person-years in the normolipidemic group (HR in patients younger than 35 years: 2.4 and 6.0). In the statin era, FH-P remains associated with high cardiovascular risk, compared with the normolipidemic population. This excess of risk is markedly high in young individuals.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher MDPI
dc.rights Copyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Incidence of cardiovascular disease in patients with familial hypercholesterolemia phenotype: analysis of 5 years follow-up of real-world data from more than 1.5 million patients
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3390/jcm8071080
dc.subject.keyword Familial Hypercholesterolemia
dc.subject.keyword Atherosclerosis
dc.subject.keyword Cardiovascular diseases
dc.subject.keyword Incidence
dc.subject.keyword Prevention
dc.subject.keyword Real-world data
dc.subject.keyword Risk assessment
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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