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In-utero and childhood chemical exposome in six European mother-child cohorts

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dc.contributor.author Haug, Line Småstuen
dc.contributor.author Casas Sanahuja, Maribel
dc.contributor.author Maitre, Léa
dc.contributor.author Basagaña Flores, Xavier
dc.contributor.author De Bont, Jeroen, 1989-
dc.contributor.author González, Juan Ramón
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Urquiza, José M.
dc.contributor.author Vrijheid, Martine
dc.contributor.author Thomsen, Cathrine
dc.date.accessioned 2020-01-16T08:43:37Z
dc.date.available 2020-01-16T08:43:37Z
dc.date.issued 2018
dc.identifier.citation Haug LS, Sakhi AK, Cequier E, Casas M, Maitre L, Basagana X et al. In-utero and childhood chemical exposome in six European mother-child cohorts. Environ Int. 2018;121(Pt 1):751-63. DOI: 10.1016/j.envint.2018.09.056
dc.identifier.issn 0160-4120
dc.identifier.uri http://hdl.handle.net/10230/43302
dc.description.abstract Background: Harmonized data describing simultaneous exposure to a large number of environmental contaminants in-utero and during childhood is currently very limited. Objectives: To characterize concentrations of a large number of environmental contaminants in pregnant women from Europe and their children, based on chemical analysis of biological samples from mother-child pairs. Methods: We relied on the Early-Life Exposome project, HELIX, a collaborative project across six established population-based birth cohort studies in Europe. In 1301 subjects, biomarkers of exposure to 45 contaminants (i.e. organochlorine compounds, polybrominated diphenyl ethers, per- and polyfluoroalkyl substances, toxic and essential elements, phthalate metabolites, environmental phenols, organophosphate pesticide metabolites and cotinine) were measured in biological samples from children (6-12 years) and their mothers during pregnancy, using highly sensitive biomonitoring methods. Results: Most of the exposure biomarkers had high detection frequencies in mothers (35 out of 45 biomarkers with >90% detected) and children (33 out of 45 biomarkers with >90% detected). Concentrations were significantly different between cohorts for all compounds, and were generally higher in maternal compared to children samples. For most of the persistent compounds the correlations between maternal and child concentrations were moderate to high (Spearman Rho > 0.35), while for most non-persistent compounds correlations were considerably lower (Spearman Rho < 0.15). For mercury, PFOS and PFOA a considerable proportion of the samples of both mothers and their children exceeded the HBM I value established by The Human Biomonitoring Commission of the German Federal Environment Agency. Discussion: Although not based on a representative sample, our study suggests that children across Europe are exposed to a wide range of environmental contaminants in fetal life and childhood including many with potential adverse effects. For values exceeding the HBM I value identification of specific sources of exposure and reducing exposure in an adequate way is recommended. Considerable variability in this "chemical exposome" was seen between cohorts, showing that place of residence is a strong determinant of one's personal exposome. This extensive dataset comprising >100,000 concentrations of environmental contaminants in mother-child pairs forms a unique possibility for conducting epidemiological studies using an exposome approach.
dc.description.sponsorship The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP7/2007–2013) under grant agreement no 308333 – the HELIX project. Dr. Regina Grazuleviciene received the grant of the Lithuanian Agency for Science Innovation and Technology (No. 31V-77). Dr. Maribel Casas received funding from Instituto de Salud Carlos III (Ministry of Economy and Competitiveness) (MS16/00128). Rosie McEachan and John Wright were supported by the NIHR CLAHRC Yorkshire and Humber (IS-CLA-0113-10020). www.clahrc-yh.nihr.ac.uk. The INMA (Environment and Childhood) Sabadell cohort and biomarker measurements were funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; PI041436; PI081151 incl. FEDER funds; PI12/01890 incl. FEDER funds; CP13/00054 incl. FEDER funds), CIBERESP, Generalitat de Catalunya-CIRIT 1999SGR 00241, Generalitat de Catalunya-AGAUR (2009 SGR 501, 2014 SGR 822), Fundació La marató de TV3 (090430), Spanish Ministry of Economy and Competitiveness (SAF2012-32991 incl. FEDER funds). The Norwegian Mother and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research, NIH/NINDS (grant no.1 UO1 NS 047537-01 and grant no.2 UO1 NS 047537-06A1). The REAH cohort was financially supported by European projects (EU FP6-2003-Food-3-NewGeneris, EU FP6. STREP Hiwate, EU FP7 ENV.2007.1.2.2.2. Project No 211250 Escape, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009- single stage CHICOS, EU FP7 ENV.2008.1.2.1.6. Proposal No 226285 ENRIECO, EU- FP7- HEALTH-2012 Proposal No 308333 HELIX), the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011–2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–15).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Environment International. 2018;121(Pt 1):751-63
dc.rights © 2018 Elsevier Ltd. This article is available under the Creative Commons CC-BY-NC-ND license (https://creativecommons.org/licenses/by-nc-nd/4.0/) and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed.
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title In-utero and childhood chemical exposome in six European mother-child cohorts
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2018.09.056
dc.subject.keyword Children
dc.subject.keyword Exposome
dc.subject.keyword Exposure
dc.subject.keyword Mother-child pairs
dc.subject.keyword Pregnant women
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-32991
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226285
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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