Welcome to the UPF Digital Repository

COPD: preclinical models and emerging therapeutic targets

Show simple item record

dc.contributor.author Barreiro Portela, Esther
dc.contributor.author Wang, Xuejie
dc.contributor.author Tang, Jun
dc.date.accessioned 2020-01-16T07:33:12Z
dc.date.issued 2019
dc.identifier.citation Barreiro E, Wang X, Tang J. COPD: preclinical models and emerging therapeutic targets. Expert Opin Ther Targets. 2019 Oct;23(10):829-38. DOI: 10.1080/14728222.2019.1667976
dc.identifier.issn 1472-8222
dc.identifier.uri http://hdl.handle.net/10230/43298
dc.description.abstract Introduction: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Preclinical models of COPD have recently been developed. In those models, COPD/emphysema has been commonly induced using different toxic agents such as elastase, proteolytic enzymes and chronic exposure to cigarette smoke (CS). Areas covered: The most relevant features of preclinical models of COPD, namely chronic exposure to CS and other agents (proteases and microorganisms), cardiovascular effects, surfactant protein-D, airway remodeling and inflammation, lung regeneration potential and mesenchymal stromal cell therapy are described. The most relevant publications on the topic of interest were selected from Pubmed. Expert opinion: Preclinical models of COPD are key for understanding the underlying biology and pathophysiology of the disease and for the discovery of therapeutic targets. Enhanced biological insights will help discover therapeutic targets for the treatment of COPD. This will enable health caregivers and doctors to improve treatment where a more holistic approach will be used. This will benefit the patients and society because the use of resources should be significantly lowered.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Informa Healthcare
dc.relation.ispartof Expert Opinion on Therapeutic Targets. 2019 Oct;23(10):829-38
dc.rights © Informa Healthcare. This is an electronic version of an article published in Barreiro E, Wang X, Tang J. COPD: preclinical models and emerging therapeutic targets. Expert Opin Ther Targets. 2019 Oct;23(10):829-838. http://dx.doi.org/1080/14728222.2019.1667976
dc.title COPD: preclinical models and emerging therapeutic targets
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1080/14728222.2019.1667976
dc.subject.keyword Animal models
dc.subject.keyword COPD
dc.subject.keyword Cigarette smoke exposure
dc.subject.keyword Lung regeneration potential
dc.subject.keyword Mesenchymal stromal cells
dc.subject.keyword Surfactant protein-D
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account


Compliant to Partaking