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Absence of tangentially migrating glutamatergic neurons in the developing avian brain

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dc.contributor.author García-Moreno, Fernando
dc.contributor.author Anderton, Edward
dc.contributor.author Jankowska, Marta
dc.contributor.author Begbie, Jo
dc.contributor.author Encinas, Juan Manuel
dc.contributor.author Irimia, Manuel
dc.contributor.author Molnár, Zoltán
dc.date.accessioned 2019-11-12T11:43:29Z
dc.date.available 2019-11-12T11:43:29Z
dc.date.issued 2018
dc.identifier.citation García-Moreno F, Anderton E, Jankowska M, Begbie J, Encinas JM, Irimia M, Molnár Z. Absence of tangentially migrating glutamatergic neurons in the developing avian brain. Cell Rep. 2018; 22(1):96-109. DOI 10.1016/j.celrep.2017.12.032
dc.identifier.issn 2211-1247
dc.identifier.uri http://hdl.handle.net/10230/42823
dc.description.abstract Several neuronal populations orchestrate neocortical development during mammalian embryogenesis. These include the glutamatergic subplate-, Cajal-Retzius-, and ventral pallium-derived populations, which coordinate cortical wiring, migration, and proliferation, respectively. These transient populations are primarily derived from other non-cortical pallial sources that migrate to the dorsal pallium. Are these migrations to the dorsal pallium conserved in amniotes or are they specific to mammals? Using in ovo electroporation, we traced the entire lineage of defined chick telencephalic progenitors. We found that several pallial sources that produce tangential migratory neurons in mammals only produced radially migrating neurons in the avian brain. Moreover, ectopic expression of VP-specific mammalian Dbx1 in avian brains altered neurogenesis but did not convert the migration into a mammal-like tangential movement. Together, these data indicate that tangential cellular contributions of glutamatergic neurons originate from outside the dorsal pallium and that pallial Dbx1 expression may underlie the generation of the mammalian neocortex during evolution.
dc.description.sponsorship F.G.-M. was supported by Human Frontiers Science Program Long-Term Postdoctoral Fellowship Program LT000618/2011-L and currently holds an IKERBASQUE research fellowship. Z.M. holds research grants from the Biotechnology and Biological Sciences Research Council, the Wellcome Trust, and the Medical Research Council UK. M.I. is supported by grants from the European Research Council (ERC-StG-LS2-637591) and the Spanish Ministry of Economy and Competitiveness (BFU2014-55076-P to M.I. and “Centro de Excelencia Severo Ochoa 2013-2017” and SEV-2012-0208 to the Centre for Genomic Regulation [CRG]). We acknowledge the support of the CERCA Programme/Generalitat de Catalunya. J.M.E. holds MINECO SAF-2015-70866-R (with FEDER funds) and RyC-2012-11137 grants.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Cell Rep. 2018; 22(1):96-109
dc.rights © 2017 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/)
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Absence of tangentially migrating glutamatergic neurons in the developing avian brain
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.celrep.2017.12.032
dc.subject.keyword Dbx1
dc.subject.keyword Chick
dc.subject.keyword Evo-devo
dc.subject.keyword Evolution
dc.subject.keyword Neocortex
dc.subject.keyword Pallium
dc.subject.keyword Telencephalon
dc.subject.keyword Ventral pallium
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-55076-P
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2015-70866-R
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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