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Return to the sea, get huge, beat cancer: an analysis of cetacean genomes including an asssembly for the humpback whale (megaptera novaeangliae)

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dc.contributor.author Tollis, Marc
dc.contributor.author Robbins, Jooke
dc.contributor.author Webb, Andrew E.
dc.contributor.author Kuderna, Lukas, 1989-
dc.contributor.author Caulin, Aleah F.
dc.contributor.author Garcia, Jacinda D.
dc.contributor.author Bèrubè, Martine
dc.contributor.author Pourmand, Nader
dc.contributor.author Marquès i Bonet, Tomàs, 1975-
dc.contributor.author O'Connell, Mary J.
dc.contributor.author Palsbøll, Per J.
dc.contributor.author Maley, Carlo C.
dc.date.accessioned 2019-11-05T08:52:51Z
dc.date.available 2019-11-05T08:52:51Z
dc.date.issued 2019
dc.identifier.citation Tollis M, Robbins J, Webb AE, Kuderna LFK, Caulin AF, Garcia JD et al. Return to the sea, get huge, beat cancer: an analysis of cetacean genomes including an asssembly for the humpback whale (megaptera novaeangliae). Mol Biol Evol. 2019;36(8):1746-63. DOI: 10.1093/molbev/msz099
dc.identifier.issn 0737-4038
dc.identifier.uri http://hdl.handle.net/10230/42704
dc.description.abstract Cetaceans are a clade of highly specialized aquatic mammals that include the largest animals that have ever lived. The largest whales can have ∼1,000× more cells than a human, with long lifespans, leaving them theoretically susceptible to cancer. However, large-bodied and long-lived animals do not suffer higher risks of cancer mortality than humans-an observation known as Peto's Paradox. To investigate the genomic bases of gigantism and other cetacean adaptations, we generated a de novo genome assembly for the humpback whale (Megaptera novaeangliae) and incorporated the genomes of ten cetacean species in a comparative analysis. We found further evidence that rorquals (family Balaenopteridae) radiated during the Miocene or earlier, and inferred that perturbations in abundance and/or the interocean connectivity of North Atlantic humpback whale populations likely occurred throughout the Pleistocene. Our comparative genomic results suggest that the evolution of cetacean gigantism was accompanied by strong selection on pathways that are directly linked to cancer. Large segmental duplications in whale genomes contained genes controlling the apoptotic pathway, and genes inferred to be under accelerated evolution and positive selection in cetaceans were enriched for biological processes such as cell cycle checkpoint, cell signaling, and proliferation. We also inferred positive selection on genes controlling the mammalian appendicular and cranial skeletal elements in the cetacean lineage, which are relevant to extensive anatomical changes during cetacean evolution. Genomic analyses shed light on the molecular mechanisms underlying cetacean traits, including gigantism, and will contribute to the development of future targets for human cancer therapies.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof Molecular Biology and Evolution. 2019;36(8):1746-63
dc.rights © The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Return to the sea, get huge, beat cancer: an analysis of cetacean genomes including an asssembly for the humpback whale (megaptera novaeangliae)
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/molbev/msz099
dc.subject.keyword Cancer
dc.subject.keyword Cetaceans
dc.subject.keyword Evolution
dc.subject.keyword Genome
dc.subject.keyword Humpback whale
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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