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Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)

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dc.contributor.author Castro Giner, Francesc
dc.contributor.author Künzli, Nino
dc.contributor.author Jacquemin Leonard, Bénédicte
dc.contributor.author Forsberg, Bertil
dc.contributor.author Cid Ibeas, Rafael de
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Jarvis, Deborah
dc.contributor.author Briggs, David
dc.contributor.author Vienneau, Danielle
dc.contributor.author Norbäck, Dan
dc.contributor.author Gonzalez, Juan Ramon
dc.contributor.author Guerra, Stefano
dc.contributor.author Janson, Christer
dc.contributor.author Antó i Boqué, Josep Maria
dc.contributor.author Wjst, Matthias
dc.contributor.author Heinrich, Joachim
dc.contributor.author Estivill, Xavier, 1955-
dc.contributor.author Kogevinas, Manolis
dc.date.accessioned 2019-07-10T07:23:35Z
dc.date.available 2019-07-10T07:23:35Z
dc.date.issued 2009
dc.identifier.citation Castro-Giner F, Künzli N, Jacquemin B, Forsberg B, de Cid R, Sunyer J et al. Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS). Environ Health Perspect. 2009 Dec;117(12):1919-24. DOI: 10.1289/ehp.0900589
dc.identifier.issn 0091-6765
dc.identifier.uri http://hdl.handle.net/10230/41970
dc.description.abstract BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association between home outdoor levels of modeled nitrogen dioxide and asthma. METHODS: Adults from 13 cities of the second European Community Respiratory Health Survey (ECRHS II) were included (n = 2,920), for whom both DNA and outdoor NO(2) estimates were available. Home addresses were geocoded and linked to modeled outdoor NO(2) estimates, as a marker of local traffic-related pollution. We examined asthma prevalence and evaluated polymorphisms in genes involved in oxidative stress pathways [gluthatione S-transferases M1 (GSTM1), T1 (GSTT1), and P1 (GSTP1) and NAD(P)H:quinine oxidoreductase (NQO1)], inflammatory response [tumor necrosis factor alpha (TNFA)], immunologic response [Toll-like receptor 4 (TLR4)], and airway reactivity [adrenergic receptor beta2 (ADRB2)]. RESULTS: The association between modeled NO(2) and asthma prevalence was significant for carriers of the most common genotypes of NQO1 rs2917666 [odds ratio (OR) = 1.54; 95% confidence interval (CI), 1.10-2.24], TNFA rs2844484 (OR = 2.02; 95% CI, 1.30-3.27). For new-onset asthma, the effect of NO(2) was significant for the most common genotype of NQO1 rs2917666 (OR = 1.52; 95% CI, 1.09-2.16). A significant interaction was found between NQO1 rs2917666 and NO(2) for asthma prevalence (p = 0.02) and new-onset asthma (p = 0.04). CONCLUSIONS: Genetic polymorphisms in the NQO1 gene are related to asthma susceptibility among persons exposed to local traffic-related air pollution. This points to the importance of antioxidant pathways in the protection against the effects of air pollution on asthma.
dc.description.sponsorship This work was supported by grants from MaratoTV3, Catalonia, Spain, and from Genome Spain. Additional funding was available in each research center for data collection
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher National Institute of Environmental Health Sciences (NIEHS)
dc.relation.ispartof Environmental Health Perspectives. 2009 Dec;117(12):1919-24
dc.rights Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, "Reproduced with permission from Environmental Health Perspectives"); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright
dc.subject.other Asma
dc.subject.other Estrès oxidatiu
dc.subject.other Genètica
dc.subject.other Aire -- Contaminació
dc.subject.other Automòbils -- Aspectes ambientals
dc.title Traffic-related air pollution, oxidative stress genes, and asthma (ECHRS)
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1289/ehp.0900589
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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