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Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome

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dc.contributor.author Blanco Hinojo, Laura, 1981-
dc.contributor.author Pujol Martí, Jesús, 1981-
dc.contributor.author Esteba-Castillo, Susanna
dc.contributor.author Martínez-Vilavella, Gerard
dc.contributor.author Giménez Palop, Olga
dc.contributor.author Gabaue, Elisabeth
dc.contributor.author Casamitjana, Laia
dc.contributor.author Deus, Joan
dc.contributor.author Novell, Ramon
dc.contributor.author Caixàs, Assumpta
dc.date.accessioned 2019-06-19T08:06:52Z
dc.date.available 2019-06-19T08:06:52Z
dc.date.issued 2019
dc.identifier.citation Blanco-Hinojo L, Pujol J, Esteba-Castillo S, Martínez-Vilavella G, Giménez-Palop O, Gabau E. Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome. Neuroimage Clin. 2019;21:101662. DOI: 10.1016/j.nicl.2019.101662
dc.identifier.issn 2213-1582
dc.identifier.uri http://hdl.handle.net/10230/41831
dc.description.abstract OBJECTIVE: To investigate, based on a putative abnormal neural processing of disgusting signals in Prader Willi syndrome (PWS) patients, the brain response to visual representations of disgusting food in PWS using functional MRI (fMRI). METHODS: Twenty-one genetically-confirmed PWS patients, 30 age- and sex-matched and 28 BMI-matched control subjects viewed a movie depicting disgusting food-related scenes interspersed with scenes of appetizing food while fMRI was acquired. Brain activation maps were compared between groups and correlated with disgust and hunger ratings. RESULTS: At the cortical level, the response to disgusting food representations in PWS patients was qualitatively similar to that of control subjects, albeit less extensive, and engaged brain regions typically related to visually-evoked disgust, such as the anterior insula/frontal operculum, the lateral frontal cortex and visual areas. By contrast, activation was almost absent in limbic structures directly concerned with the regulation of instinctive behavior robustly activated in control subjects, such as the hypothalamus, amygdala/hippocampus and periaqueductal gray. CONCLUSIONS: Our study provides novel insights into the neural substrates of appetite control in a genetically-mediated cause of obesity. The presence of significant cortical changes further indicates that PWS patients consciously process disgusting stimuli, but the virtual absence of response in deep, limbic structures suggests that disgusting signals do not adequately reach the primary brain system for the appetite control.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights Copyright © 2019 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Lack of response to disgusting food in the hypothalamus and related structures in Prader Willi syndrome
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.nicl.2019.101662
dc.subject.keyword Functional MRI
dc.subject.keyword Disgust
dc.subject.keyword Hypothalamus
dc.subject.keyword Prader Willi syndrome
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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