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Vitamin D levels in mediterranean breast cancer patients compared with those in healthy women

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dc.contributor.author Pineda-Moncusí, Marta
dc.contributor.author García-Pérez, Miguel Angel
dc.contributor.author Rial, Abora
dc.contributor.author Casamayor, Guillem
dc.contributor.author Cos, Maria Lourdes
dc.contributor.author Servitja Tormo, Sonia
dc.contributor.author Tusquets, Ignasi
dc.contributor.author Díez Pérez, Adolfo
dc.contributor.author Cano, Antonio
dc.contributor.author Garcia Giralt, Natàlia
dc.contributor.author Nogués Solan, Francesc Xavier
dc.date.accessioned 2019-06-12T07:28:28Z
dc.date.issued 2018
dc.identifier.citation Pineda-Moncusí M, Garcia-Perez MA, Rial A, Casamayor G, Cos ML, Servitja S. et al. Vitamin D levels in mediterranean breast cancer patients compared with those in healthy women. Maturitas. 2018 Oct;116:83-88. DOI: 10.1016/j.maturitas.2018.07.015
dc.identifier.issn 0378-5122
dc.identifier.uri http://hdl.handle.net/10230/41740
dc.description.abstract To evaluate the vitamin D status of postmenopausal women with early estrogen-receptor-positive breast cancer and to compare it with that of healthy postmenopausal women from the same Mediterranean region. STUDY DESIGN AND OUTCOME MEASURES: Data from 691 breast cancer (BC) patients in the B-ABLE cohort were analyzed after recent cancer intervention (recent-BC) or after a minimum of two years since this intervention (long-term-BC). Patients were also stratified by previous chemotherapy exposure (ChT+ and ChT-). Plasma levels of 25-hydroxyvitamin D [25(OH)D] (25(OH)D) were compared with data from 294 healthy women (non-BC) by linear regression to estimate β-coefficients using non-BC participants as the reference group. Age, body mass index and season of blood extraction were selected as potential confounders. RESULTS: Of the recent-BC patients, 23.7% had 25(OH)D deficiency, compared with 17.7% of the long-term-BC group, and just 1.4% of the non-BC participants. Most of the women were located in the insufficient 25(OH)D category regardless of study group. BC patients had significantly lower 25(OH)D levels than non-BC participants (adjusted β-coefficients: -4.84 [95%CI -6.56 to -3.12] in recent-BC, and -2.05 [95%CI -4.96 to -0.14] in long-term-BC). Among BC patients, the lowest 25(OH)D levels were found in the recent-BC (ChT+) group (p < 0.001). No differences were found between the long-term-BC (ChT-), long-term-BC (ChT+) and recent-BC (ChT-) groups. Among the BC ChT+ patients, the recent-BC group had significantly lower 25(OH)D levels than the long-term-BC group (p < 0.001). CONCLUSION: Severely reduced 25(OH)D levels were detected in patients with breast cancer, particularly after recent chemotherapy. These 25(OH)D levels had partially recovered over the long term, but still remained much lower than in the healthy population.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights © Elsevier http://dx.doi.org/10.1016/j.maturitas.2018.07.015
dc.title Vitamin D levels in mediterranean breast cancer patients compared with those in healthy women
dc.type info:eu-repo/semantics/article
dc.subject.keyword B-ABLE cohort study
dc.subject.keyword Breast cancer
dc.subject.keyword Chemotherapy
dc.subject.keyword Vitamin D
dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
dc.type.version info:eu-repo/semantics/acceptedVersion
dc.embargo.liftdate 2019-10-31
dc.date.embargoEnd info:eu-repo/date/embargoEnd/2019-10-31


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