• Elucidation of disease-related protein networks underlying Dyrk1A overexpression and pro-cognitive therapies in the hippocampus

  Ortega Crespo, Mireia, 1988- (Universitat Pompeu Fabra, 2018-01-23)

  Down syndrome (DS) is the most frequent genetic cause of intellectual disability. It is a multifaceted condition characterized by impairments in cognition, communication, behavior and/or motor skills resulting from abnormal ...
• Tyrosol and its endogenous conversion into hydroxytyrosol in humans : Dietary sources, genetic modulation and clinical effects

  Boronat Rigol, Anna, 1990- (Universitat Pompeu Fabra, 2020-01-16)

  Hydroxytyrosol is a health-promoting dietary phenol mainly present in extra virgin olive oil. Wine and beer are sources of tyrosol, a related phenolic compound. We have demonstrated that in humans tyrosol is endogenously ...
• Evolutionary dynamics of transcriptional and translational regulation in yeast

  Blevins, William Robert, 1987- (Universitat Pompeu Fabra, 2020-01-17)

  All living organisms respond to environmental stimuli by modulating the activity of different genes. This response can occur across many locations throughout the cell such as at the level of transcription, translation, and ...
• Managerial opportunism, US conveyancing and blockchain

  Antelo Muñiz, Fátima (Universitat Pompeu Fabra, 2019-10-25)

  This thesis is structured in three chapters. In chapter 1, I address managerial opportunism towards workers. I present a theoretical model and test it. Results suggest that outside opportunities are key to hinder or ...
• TANGO1 asembles a machine for collagen folding and export

  Ashok, Anupama, 1985- (Universitat Pompeu Fabra, 2019-01-21)

  COPII vesicles of 60-90nm diameter are known to export secretory cargoes from endoplasmic reticulum (ER). However, they cannot be employed to export bulky cargoes like the collagens that can reach up to 400 nm in length. ...
• Circular RNAs : from host RNA molecules to novel broad-spectrum antivirals

  Talló Parra, Marc, 1992- (Universitat Pompeu Fabra, 2019-12-17)

  La rellevància clínica dels virus transmesos per mosquits, com el virus del dengue (DENV), el virus del zika (ZIKV), el virus del chikungunya (CHIKV) i el virus del Nil Occidental (WNV), ha augmentat dràsticament durant ...
• A Computational toolkit to boost precision oncology with pharmacogenomics

  Mateo Ramos, Lídia, 1989- (Universitat Pompeu Fabra, 2019-12-18)

  Durant la darrera dècada la seqüenciació massiva de pacients de cancer ha permés avançar de forma significativa el coneixement sobre les bases moleculars del càncer. Un cop assolit aquest primer pass, el repte que tenim ...
• Inequalities in health and health behaviours amongst couple and lone mothers : The influence of socioeconomic factors and social capital in Spain and Europe

  Trujillo Alemán, Sara, 1985- (Universitat Pompeu Fabra, 2019-12-20)

  This PhD research has three main aims: first, to design a conceptual framework for studying health inequalities amongst women who are mothers; secondly, to describe inequalities in health and health behaviours between ...
• Essays in financial econòmics

  Pandolfi, Lorenzo (Universitat Pompeu Fabra, 2018-01-22)

  This thesis consists of three chapters contributing to the broad field of financial economics. In the first chapter, I develop a theoretical model of bank bail-ins in order to analyze the effects of the implementation of ...
• Highly accurate variant detection for identification of tumor mutations and mosaic variants

  Muyas Remolar, Francesc, 1992- (Universitat Pompeu Fabra, 2019-12-20)

  The rapid development of high-throughput sequencing technologies pushed forward the fields of medical genomics and precision medicine, creating many new applications for diagnostics and clinical studies that require high ...
• Unraveling the complex signaling behavior of neurotransmitters and their receptors in the brain

  Stepniewski, Tomasz Maciej, 1988- (Universitat Pompeu Fabra, 2020-01-09)

  G protein-coupled receptors (GPCRs) are the main acceptors of neurotransmitters, and thus play an important role in communication between neurons. Because of this they are an attractive drug target for multiple neurodegenerative ...
• Antitumor effects of novel targeted therapies (TAK-228 and TAK-117) with high selectivity againts PI3K/AKT/mTOR pathway in bladder cancer : Defining molecular markers

  Hernández Prat, Anna, 1984- (Universitat Pompeu Fabra, 2017-12-15)

  El càncer de bufeta avançat s'associa amb un mal pronòstic i amb opcions limitades de tractament. Tot i l’èxit recent amb l'ús d'inhibidors immunitaris, no tots els pacients responen a la teràpia i encara hi ha la necessitat ...
• Characterization of sexual commitment and the early steps of sexual development in the human malaria parasite Plasmodium falciparum

  Llorà Batlle, Oriol, 1992- (Universitat Pompeu Fabra, 2019-12-19)

  Transmission of malaria requires that some parasites abandon asexual replication and develop into sexual stages termed gametocytes. The discovery of the transcription factor PfAP2-G as the master regulator of sexual ...
• The Exonuclease Xrn1 : a key regulator of gene expression under physiological and perturbed conditions

  Campos Mata, Leire de, 1991- (Universitat Pompeu Fabra, 2019-12-18)

  The highly conserved exonuclease Xrn1 plays a dual role in gene expression by degrading cellular mRNAs and promoting their transcription initiation and elongation. In this thesis we uncover an unanticipated role of Xrn1 ...
• Cancer-associated fibropalsts and response to anti-HER2 monoclonal antibodies in breast cancer

  Guardia Valenzuela, Cristina, 1990- (Universitat Pompeu Fabra, 2019-12-19)

  HER2-positive breast cancer (BC) is an aggressive subtype of this disease. The development of anti-HER2 targeted therapies, particularly the monoclonal antibody (Mab) trastuzumab, significantly improved its otherwise poor ...
• Big data, poder y libertad. Sobre el impacto social y político de la vigilancia masiva

  Suárez Gonzalo, Sara (Universitat Pompeu Fabra, 2019-12-16)

  Esta tesis doctoral reflexiona sobre el impacto social y político de la explotación de datos masivos a nivel europeo. Cumple dos objetivos principales. En primer lugar, define el contexto general en el que se produce esta ...
• Non-vertical genomics in fungal evolution

  Naranjo Ortiz, Miguel Ángel, 1989- (Universitat Pompeu Fabra, 2019-01-18)

  Non-vertical genomic events, which include horizontal gene transfer (HGT) and hybridization, are widely studied evolutionary processes in certain groups. HGT is particularly well known for prokaryotic organisms, while ...
• Computationl and modeling approaches to multi-scale anatomical description of neuronal circuitry

  Manubens-Gil, Linus, 1989- (Universitat Pompeu Fabra, 2018-01-18)

  During the last century the nervous system has been mainly studied from a reductionistic approach, based on the hypothesis that understanding in depth single neurons or limited neuronal populations would lead to general ...
• Political parties and immigrant associations: alliances in the presence of politicized immigration conflicts at the local level: a comparative study

  Triviño Salazar, Juan Carlos (Universitat Pompeu Fabra, 2016-01-18)

  La presente tesis doctoral investiga la formación de alianzas entre partidos políticos y asociaciones de inmigrantes en presencia de conflictos politizados sobre inmigración a nivel local. Esta investigación incorpora la ...
• Regulation of T cell fates by the transcription factor NFAT5 in different microenvironments

  Alberdi Ibarzabal, Maria, 1986- (Universitat Pompeu Fabra, 2015-07-24)

  CD4+ T cells can adopt specific functional programs in response to changes in microenvironment variables, such as cytokine availability, cell-to-cell contacts and stress conditions. It has been described that the elevation ...

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