• Targeting aging and Alzheimer's disease : from GM1 ganglioside to amyloide-β peptide

  Valls Comamala, Victòria, 1987- (Universitat Pompeu Fabra, 2018-09-07)

  Aging is the main challenge that humanity will face on the near future. Brain aging is associated with cognitive deficiencies and is the main risk factor for Alzheimer’s Disease (AD). AD is the most common neurodegenerative ...
• An Integrative approach to the systematics and evolution of some selected reptile groups from Arabia

  Simó Riudalbas , Marc, 1988- (Universitat Pompeu Fabra, 2018-07-20)

  Until relatively recently, many groups of terrestrial reptiles were considered to contain only few species vastly distributed across the Arabian Peninsula. This was mostly the result of the apparent morphological uniformity ...
• The Role of blue spaces on health and well-being

  Vert Roca, Cristina, 1991- (Universitat Pompeu Fabra, 2020-06-26)

  The incorporation and regeneration of blue spaces in urban areas could promote health in cities. Nevertheless, research on the effects of these spaces is still scarce. This thesis aimed to evaluate the influence of blue ...
• Educational institutions and their effect on inequality: three papers on educational systems and inequality of achievement and opportunity

  Cimentada, Jorge (Universitat Pompeu Fabra, 2019-09-25)

  By placing particular attention to the socio-economic dimension, this thesis explores the role of three pillars of an educational system: decentralization, early education and curricular tracking. The first article focuses ...
• GPCRmd - A web platform for collection, visualization and analysis of molecular dynamics data for G protein-coupled receptors : Bridging the gap between dynamics and receptor functionality

  Rodríguez Espigares, Ismael, 1990- (Universitat Pompeu Fabra, 2018-04-04)

  In this thesis, we present GPCRmd, an online repository with a submission system and visualization platform specifically designed for storing and providing easy access to molecular dynamics (MD) data of G protein-coupled ...
• Childhood obesity : interrelation amoong diet quality, lifestyle factors, and obesity

  Bawaked, Rowaedh Ahmed, 1985- (Universitat Pompeu Fabra, 2018-10-08)

  La obesidad infantil sigue siendo una importante carga para la salud pública. Comprender e identificar la compleja relación entre la calidad de la dieta y los factores del estilo de vida es importante para el control de ...
• Study of the neurobiological mechanisms involved in the development of eating and addictive disorders

  Gutiérrez Martos, Miriam, 1989- (Universitat Pompeu Fabra, 2018-06-08)

  Drug addiction and several eating disorders share striking similarities in their behavioural patterns triggered by the presence of neuronal alterations in the brain reward circuit. In this Thesis, we investigate the ...
• El Derecho humano al medio ambiente: una propuesta ecocéntrica

  Solà Pardell, Oriol, 1976- (Universitat Pompeu Fabra, 2020-09-09)

  La tesis doctoral El derecho humano al medio ambiente: una propuesta ecocéntrica tiene como objeto colmar un vacío en el ámbito del derecho internacional: el espacio que ocupa la intersección de los límites planetarios, ...
• Deep learning for drug design : modeling molecular shapes

  Skalic, Miha, 1990- (Universitat Pompeu Fabra, 2019-07-30)

  Designing novel drugs is a complex process which requires finding molecules in a vast chemical space that bind to a specific biomolecular target and have favorable physio-chemical properties. Machine learning methods can ...
• Alignment uncertainty, regressive alignment and large scale deployment

  Floden, Evan, 1985- (Universitat Pompeu Fabra, 2018-11-30)

  A multiple sequence alignment (MSA) provides a description of the relationship between biological sequences where columns represent a shared ancestry through an implied set of evolutionary events. The majority of research ...
• Urban environment, transport behaviours, and health

  Avila-Palencia, Ione, 1985- (Universitat Pompeu Fabra, 2018-11-21)

  Urban environments are very complex systems with a myriad of factors intricately related. Built environment, transport, physical activity and sedentary behaviours, air pollution, and social contacts and feelings of loneliness ...
• Affective disorders and neuropathic pain as mutually influential factors : contribution of the opioid system

  Martínez Navarro, Miriam, 1990- (Universitat Pompeu Fabra, 2019-01-18)

  La alta variabilidad interindividual en las manifestaciones de dolor neuropático puede conducir a una respuesta diferencial de los pacientes a los tratamientos, y sugiere la idoneidad de terapias más personalizadas en lugar ...
• Genetic and epigenetic mechanisms regulating the G1-S transcriptional wave in fission yeast

  González Medina, Alberto, 1990- (Universitat Pompeu Fabra, 2019-03-01)

  The control of proper progression of eukaryotic cell cycle is essential if cells want to continue proliferating appropriately, and it is a conserve feature from yeast to human cells. One of the most important points of ...
• Identification of clinically relevant genetic variation in immune-mediated inflammatory diseases using genome-wide approaches

  Aterido Ballonga, Adrià, 1990- (Universitat Pompeu Fabra, 2019-02-26)

  Rheumatoid arthritis, psoriasis, psoriatic arthritis, systemic lupus erythematosus, Crohn’s disease and ulcerative colitis are six of the most prevalent immune-mediated inflammatory diseases (IMIDs) and are associated with ...
• From networks to population-specific adaptations : studying positive selection in humans

  Dobón Berenguer, Begoña, 1987- (Universitat Pompeu Fabra, 2018-11-23)

  The evolution of the genome is driven, among other factors, by the composition of the genome, the functional output of the gene products, and by environmental pressures. Among the environmental factors, pathogens are one ...
• Translational control by the RNA-binding protein CSDE1 : Insights into a stimulatory role in translation elongation

  Ní Chárthaigh, Róisín-Ana (Universitat Pompeu Fabra, 2020-07-03)

  RNA-binding proteins are potent regulators of post-transcriptional gene expression. Among the repertoire of RNAs bound by a particular RNA-binding protein, networks of co-ordinately regulated RNAs, or ‘regulons’, are ...
• Long-term exposure to greenspace and healthy ageing

  Keijzer, Carmen de, 1992- (Universitat Pompeu Fabra, 2019-10-25)

  As the world population is rapidly ageing and experiencing an ongoing urbanization, there is an emerging need for environments that are supportive of healthy ageing. Greenspace exposure may foster healthy ageing by promoting ...
• Implication of the disease-associated ORMDL3 in macrophage physiology

  Kiefer, Kerstin, 1986- (Universitat Pompeu Fabra, 2016-05-12)

  Genome-wide association studies linked increased ORMDL3 expression levels to several inflammatory diseases via single nucleotide polymorphisms. However, the pathophysiological mechanisms underlying this association are ...
• Mechanisms of muscle wasting in cachexia models : therapeutic implications

  Salazar Degracia, Anna, 1991- (Universitat Pompeu Fabra, 2019-04-15)

  La caquexia afecta negativamente a los pacientes con enfermedades crónicas y sobre todo en el cáncer. Las estrategias terapéuticas son aún limitadas. Los beta2-agonistas (formoterol) y el soporte nutricional (L-carnitina) ...
• Biological foundations of consonance perception : exploring phylogenetic roots and neural mechanisms

  Crespo Bojorque, Paola, 1985- (Universitat Pompeu Fabra, 2016-12-02)

  La consonancia es una de las características más salientes de la música. A pesar de su papel fundamental en la música occidental, sus orígenes siguen siendo controversiales. Por lo tanto, la comprensión de los mecanismos ...

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