• From networks to population-specific adaptations : studying positive selection in humans

  Dobón Berenguer, Begoña, 1987- (Universitat Pompeu Fabra, 2018-11-23)

  The evolution of the genome is driven, among other factors, by the composition of the genome, the functional output of the gene products, and by environmental pressures. Among the environmental factors, pathogens are one ...
• Translational control by the RNA-binding protein CSDE1 : Insights into a stimulatory role in translation elongation

  Ní Chárthaigh, Róisín-Ana (Universitat Pompeu Fabra, 2020-07-03)

  RNA-binding proteins are potent regulators of post-transcriptional gene expression. Among the repertoire of RNAs bound by a particular RNA-binding protein, networks of co-ordinately regulated RNAs, or ‘regulons’, are ...
• Long-term exposure to greenspace and healthy ageing

  Keijzer, Carmen de, 1992- (Universitat Pompeu Fabra, 2019-10-25)

  As the world population is rapidly ageing and experiencing an ongoing urbanization, there is an emerging need for environments that are supportive of healthy ageing. Greenspace exposure may foster healthy ageing by promoting ...
• Implication of the disease-associated ORMDL3 in macrophage physiology

  Kiefer, Kerstin, 1986- (Universitat Pompeu Fabra, 2016-05-12)

  Genome-wide association studies linked increased ORMDL3 expression levels to several inflammatory diseases via single nucleotide polymorphisms. However, the pathophysiological mechanisms underlying this association are ...
• GPCRmd - A web platform for collection, visualization and analysis of molecular dynamics data for G protein-coupled receptors : Bridging the gap between dynamics and receptor functionality

  Rodríguez Espigares, Ismael, 1990- (Universitat Pompeu Fabra, 2018-04-04)

  In this thesis, we present GPCRmd, an online repository with a submission system and visualization platform specifically designed for storing and providing easy access to molecular dynamics (MD) data of G protein-coupled ...
• Childhood obesity : interrelation amoong diet quality, lifestyle factors, and obesity

  Bawaked, Rowaedh Ahmed, 1985- (Universitat Pompeu Fabra, 2018-10-08)

  La obesidad infantil sigue siendo una importante carga para la salud pública. Comprender e identificar la compleja relación entre la calidad de la dieta y los factores del estilo de vida es importante para el control de ...
• Mechanisms of muscle wasting in cachexia models : therapeutic implications

  Salazar Degracia, Anna, 1991- (Universitat Pompeu Fabra, 2019-04-15)

  La caquexia afecta negativamente a los pacientes con enfermedades crónicas y sobre todo en el cáncer. Las estrategias terapéuticas son aún limitadas. Los beta2-agonistas (formoterol) y el soporte nutricional (L-carnitina) ...
• Urban environment, transport behaviours, and health

  Avila-Palencia, Ione, 1985- (Universitat Pompeu Fabra, 2018-11-21)

  Urban environments are very complex systems with a myriad of factors intricately related. Built environment, transport, physical activity and sedentary behaviours, air pollution, and social contacts and feelings of loneliness ...
• Biological foundations of consonance perception : exploring phylogenetic roots and neural mechanisms

  Crespo Bojorque, Paola, 1985- (Universitat Pompeu Fabra, 2016-12-02)

  La consonancia es una de las características más salientes de la música. A pesar de su papel fundamental en la música occidental, sus orígenes siguen siendo controversiales. Por lo tanto, la comprensión de los mecanismos ...
• Competitive intelligence analytics for operations managers

  Tekin, Müge (Universitat Pompeu Fabra, 2018-09-17)

  This thesis incorporates three studies that revolve around competitive intelligence of a firm, available data sources and improvement of operations through data-informed decision-making. The studies cover a range of topics ...
• Effects of maternal binge alcohol consumption on emotional, cognitive and addictive behaviour in mice

  Cantacorps Centellas, Lídia, 1991- (Universitat Pompeu Fabra, 2019-11-15)

  Maternal alcohol binge drinking during pregnancy can be deleterious for the developing foetus, leading to a wide range of long-lasting morphological and neurobehavioural disabilities known as foetal alcohol spectrum ...
• Social determinants of health and the health system of Mozambique : Towards a comprehensive analysis of health inequalities

  Llop Gironés, Alba, 1987- (Universitat Pompeu Fabra, 2018-11-21)

  The present thesis aims to give a critical overview of the health care and health inequalities for the Mozambican case. The thesis is divided into four articles, two of them are quantitative articles analysing data from ...
• Determinants of the local mutation rate variability along the genome

  Frigola Rissech, Joan, 1991- (Universitat Pompeu Fabra, 2020-03-13)

  The rate at which mutations accumulate along the genome is not uniform but influenced by factors such as chromatin compactness, replication time or transcription. Most of these factors create mutational biases that encompass ...
• Cannabidiol as a potential therapeutic strategy to reduce cocaine seeking in mice

  Luján Pérez, Miguel Ángel, 1991- (Universitat Pompeu Fabra, 2020-03-13)

  Cocaine addiction is a chronic, relapsing disease characterized by the compulsive seeking and use of the drug despite its harmful consequences. Currently, there are no approved pharmacotherapies available for the treatment ...
• Transcriptional and post-transcriptional regulation across biological units and time

  Sodaei, Reza, 1988- (Universitat Pompeu Fabra, 2020-05-22)

  How do genomes generate different tissues, behaviours, individuals or species? We try to identify parts of the human transcriptome that we found only in a tissue. Then, we focus on inter-individual extreme transcriptomic ...
• Vies d'exposició a compostos organoclorats i metalls en infants

  Junqué Martínez, Eva, 1988- (Universitat Pompeu Fabra, 2019-12-18)

  En aquest estudi s’avaluen algunes de les vies d’exposició principals a diversos contaminants, concretament als compostos organoclorats (OCs) i metalls traça, en infants. La recerca se centra en tres poblacions localitzades ...
• Circadian regulation of macrophages in homeostasis and disease

  Val Casals, Maria, 1993- (Universitat Pompeu Fabra, 2020-07-09)

  Els ritmes circadians són oscil·lacions diàries en paràmetres fisiològics necessaris per a què els organismes adaptin la seva activitat als cicles de llum i foscor. A nivell molecular, la maquinària circadiana consisteix ...
• Neurogenic bowel dysfunction in subjects with brain injury : prevalence, risk factors, clinical characterization and physiopathology

  Haya Hidalgo, Jenny Rosario, 1978- (Universitat Pompeu Fabra, 2018-12-19)

  To date, there are scarce data on bowel dysfunction (BD) in patients after brain injury (BI). Until now, only fecal incontinence (FI) has received attention and it has been mainly associated to patients’ age or performance ...
• Temperature control for cell division : from microfluidics to AI

  Salaverria Izaguirre, Pablo G., 1993- (Universitat Pompeu Fabra, 2019-11-22)

  This PhD thesis aimed to understand the impact of temperature at different levels (biology to physics) while performing live-cell imaging. A study and characterization of the role of the temperature during the cell division ...
• Characterization of the human sperm centrosome and its role in (in)fertility

  Amargant i Riera, Farners, 1990- (Universitat Pompeu Fabra, 2018-07-19)

  The centrosome is an essential organelle for the development of a new organism in animals. Upon fertilization the spermatozoon enters into the oocyte providing its basal body that converts into the first centrosome of the ...

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