• Essays in macroeconomics

  Hoesch, Lukas (Universitat Pompeu Fabra, 2021-11-08)

  This thesis consists of three chapters on topics in Macroeconometrics. Chapter 1 develops a hypothesis test to evaluate economic models and their forecasts robust to instabilities. The test is particularly powerful in the ...
• Novel transcription regulators of tissue macrophages and alternative macrophage polarization

  Higuera González, Laura, 1993- (2021-10-29)

  Macrophages play crucial roles in the defense of the organism against a wide range of pathogens. Macrophages can rapidly adapt to perturbations in the microenvironment due to the existence of a network of transcription ...
• La Sanción de aislamiento en centros de menores: un estudio de la separación de grupo por días en España y Catalunya

  Ruiz Cabello, Úrsula (Universitat Pompeu Fabra, 2021-10-19)

  El principal objetivo de la tesis doctoral es profundizar en el conocimiento de la imposición y ejecución de la sanción de separación del grupo por días en España y Catalunya. Para ello, se lleva a cabo un análisis legislativo ...
• Novel genetic mechanisms in autoinflammatory diseases : Contribution of somatic and germline variation

  Solís Moruno, Manuel, 1993- (2021-10-27)

  Autoinflammatory diseases are caused by an antigen independent hyperactivation of inflammatory pathways. The first genetic defect linked to an autoinflammatory disease was described almost 25 years ago and, since then, the ...
• Cannabis modulation of social interaction in psychosis : neurobiological correlates in humans and mouse models

  Barrera Conde, Marta (Universitat Pompeu Fabra, 2023-09-15)

  Els pacients diagnosticats amb esquizofrènia o un primer episodi psicòtic (PEP) que consumeixen cànnabis presenten alteracions clíniques diferencials comparats amb els no consumidors. En aquesta tesi doctoral, hem emprat ...
• Regulation of carbohydrate metabolism upon osmostress

  Pijuan Calvet, Anna, 1993- (2021-10-22)

  Yeast deal with continuous environmental perturbations that compromise its cell fitness. Upon osmostress, HOG pathway becomes activated and leads the adaptation response. To compensate the osmotic imbalance, Hog1 is in ...
• Mechanical control of epithelial tissue formation and function in early development

  Tolosa Ramon, Queralt (Universitat Pompeu Fabra, 2023-09-15)

  The outer epithelial layer is the first cell type that emerges during development, providing essential mechanical protection and is indispensable for morphogenesis. Here, we study how the interplay between molecular and ...
• Investigating the role of Gli2 in mouse embryonic stem cells and mouse embryogenesis

  Tu, Xiaochuan (Universitat Pompeu Fabra, 2023-09-13)

  Embryonic stem cells (ESCs) are derived from the inner cell mass of the pre-implantation embryo and can recapitulate early developmental stages of the embryo. ESCs have the ability to continuously propagate while maintaining ...
• Phytocannabinoids and endocannabinoids as modulators of cocaine reinforcement in mice

  Alegre Zurano, Laia (Universitat Pompeu Fabra, 2023-09-13)

  Cocaine use profoundly disrupts the neuronal circuits that regulate reward processing, motivation and decision making, resulting in long-lasting neuroplastic adaptations in the mesocorticolimbic system. The endocannabinoid ...
• Common representations of social interaction : Neurocognitive mechanisms and their motor correlates

  Riquelme Esteve, Andrea, 1992- (2021-10-27)

  Our everyday life is plenty of social interactions, but there are still many unknowns about the mechanisms supporting them. The current dissertation aims to explore the neurocognitive processes that underlie interactions ...
• De novo heterochromatin establishment in 2C-like cells and early embryonic development

  Sebastián Perez, Rubén (2021-10-22)

  Chromocenters are established after the 2-cell (2C) stage during mouse embryonic development, but the factors that mediate chromocenter formation remain largely unknown. To identify regulators of 2C heterochromatin ...
• Toward empathic systems: implicit understanding and modulation of human cognitive and affective states

  López Carral, Héctor (Universitat Pompeu Fabra, 2023-04-14)

  Emotions are a fundamental part of human life. They play a critical role in how we think, behave, and implicitly understand each other. However, although computing devices are increasingly consequential in our world, they ...
• Targeting the RB pathway in tumor cells

  Caballero de la Torre, María, 1992- (2021-10-20)

  Retinoblastoma protein (RB) is a negative regulator of the cell cycle. In response to environmental stress, p38 MAPK phosphorylates RB in the N-terminal region, increasing the affinity of RB for E2F, repressing gene ...
• Factors determining the adult body plan in the hemimetabolan embryogenesis

  Ventos Alfonso, Alba, 1992- (2021-10-20)

  The idea of this work has been to identify factors that determine the adult body plan in hemimetabolan embryogenesis, using the cockroach Blattella germanica as model. Comparative genomics studies pointed to three factors ...
• Cancer as a complex adaptive system : Mathematical models of tumor ecology, evolution and development

  Aguadé Gorgorió, Guim (2021-09-13)

  Despite decades of scientific effort, cancer remains a major cause of death worldwide. Through the accumulation of genome alterations, tumor populations evolve the capacity to circumvent the selective barriers of tissue ...
• The Role of the LRRC8A anion channel in adaptation to stress

  Stojakovic, Predrag (Universitat Pompeu Fabra, 2023-03-10)

  Cell volume regulation is essential for cellular homeostasis and adaptation to environmental osmotic changes. Upon hyperosmotic stress, cells need to rapidly restore osmotic balances in order to preserve the function of ...
• Improving molecular diagnosis in myeloid neoplasms : The role of cell-free DNA

  García Gisbert, Nieves, 1994- (2022-03-09)

  Myeloid malignancies are clonal diseases originated in myeloid hematopoietic stem cells that are frequently initiated by somatic mutations. The detection of genetic alterations has considerably improved the diagnostic ...
• La Traducción chino-español de las metáforas sobre Relaciones de Género en la novela Wei Cheng (围城): un estudio desde la perspectiva del análisis del discurso

  Li, Hongying (Universitat Pompeu Fabra, 2023-09-04)

  Wei Cheng (围城 ), una de las obras literarias más importantes de la China moderna, es ampliamente conocida por su estilo sarcástico y el uso de abundantes metáforas. Mediante un estudio de la traducción chino-español de las ...
• Structural language change in Alzheimer's disease: a study of spontaneous speech tasks across different stages of cognitive impairment

  Chapin, Kayla (Universitat Pompeu Fabra, 2023-09-04)

  Linguistic characteristics of spontaneous connected speech are showing increasing potential for detecting and tracking cognitive decline in Alzheimer’s disease, and could be particularly suitable to study at-risk populations ...
• El concepto europeo de deuda pública

  Marco Peñas, Ester (Universitat Pompeu Fabra, 2014-02-20)

  La normativa europea en materia de disciplina presupuestaria establece un concepto autónomo de deuda pública que debe ser aplicado por los Estados miembros para dar cumplimiento a los mandatos europeos. La presente tesis ...

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