La localització de molècules d'ARNm permet regular la síntesi de proteïnes localment i temporalment i això és vital per molts processos cel·lular fonamentals. A Oligodendròcits el transport de l'ARNm de la proteïna bàsica ...
Cancer cells undergo epithelial-to-mesenchymal transition (EMT) to dissociate from the primary tumor and to survive to chemotherapy. EMT is controlled by Snail1, a transcriptional factor also required for the activation ...
Anabolic androgenic steroids (AAS) are widely used by athletes to enhance sports performance. In this thesis, different studies were performed to evaluate the potential of the direct detection of phase II metabolites by ...
During mitosis, the microtubules organize a bipolar spindle that segregates the chromosomes. In higher eukaryotes, these microtubules are nucleated through three different pathways involving the centrosomes (centrosomal ...
La aparición de Gong Li en la pantalla simboliza una apertura revolucionaria en la representación del erotismo femenino en China, después de la denominada Revolución Cultural (1966-1976). En la presente tesis se demuestra ...
Esta tesis propone un estudio estético de la representación documental del horror en el cine contemporáneo, analizando cómo el cine articula modos puesta en escena para documentar genocidios, guerras, matanzas, crímenes o ...
Imaging Genetics (IG) aims to test how genetic information influences brain structure and function, cognitive processes and complex neurodevelopmental domains, combining magnetic resonance imaging-based brain features and ...
En Discurso, Figura, el filósofo francés Jean-François Lyotard acuña un término: figural, que teóricos como Nicole Brenez, Philippe Dubois o Jean-Michel Durafour, entre otros, han llevado al terreno del análisis de la ...
La present tesi doctoral analitza, a través de l'obra i la trajectòria de David Bowie, com l'ús de cançons rock suposa un element de significació en la posada en escena del cinema contemporani, i també com una estrella pop ...
Meza Meza, Nohelia(Universitat Pompeu Fabra, 2017-09-08)
One of the major challenges in electronic literature is the search for literariness in the works. This topic is still largely debated among scholars due to the diverse representations that the literary can acquire and the ...
Insect metamorphosis is controlled by several genes that are regulated by two hormones, 20-hydroxyecdysone (20E) and juvenile hormone (JH). These genes, E93, Krüppel-homolog 1 (Kr-h1) and Broad-complex (Br-C), form a network ...
La hipótesis general de esta tesis consiste en que durante el proceso de cancerificación del epitelio pulmonar, las “driver-mutations” pueden aparecer no solamente en las células malignas sino también en cualquier célula ...
The hindbrain boundary cell population (BCP) is specified at the interface between adjacent compartments during embryonic development of the posterior brain. Hindbrain BCP is a non-neurogenic population that acts as both ...
Riera Domínguez, María Graciela, 1987-(Universitat Pompeu Fabra, 2018-12-10)
The host immune response against infection requires the coordinated action of many diverse cell subsets that dynamically adapt to a pathogen threat. Due to the complexity of such a response, most immunological studies have ...
Although universal and unavoidable, aging does not occur in a uniform way. In this dissertation, we assessed the effects of early life exposure to pro-inflammatory risk factors (air pollution and obesity) on mitochondrial ...
Triviño Salazar, Juan Carlos(Universitat Pompeu Fabra, 2016-01-18)
La presente tesis doctoral investiga la formación de alianzas entre partidos políticos y asociaciones de inmigrantes en presencia de conflictos politizados sobre inmigración a nivel local. Esta investigación incorpora la ...
Hydrogen peroxide (H2O2), a reactive oxygen species (ROS), is involved in both oxidative stress and signaling cascades in a dosage dependent manner. Its toxicity is partially explained through reactivity with iron via the ...
Tejedor Vaquero, Juan Ramón, 1984-(Universitat Pompeu Fabra, 2014-06-11)
Alternative splicing is an essential regulatory layer of gene expression that expands the coding potential of the genome in multicellular organisms. The spliceosome -the sophisticated machinery involved in intron removal- ...
L'objectiu de la tesi és explorar les desigualtats geogràfiques, de gènere i de posició socioeconòmica en la prevalença de la discapacitat visual i ceguesa. La tesi consta de 3 articles que analitzen cadascuna de les ...
Exposure to traffic-related air pollution (TRAP) has been associated with adverse health outcomes. Physical activity (PA) in polluted air may increase pollutant uptake and hence affect health. The main aim of this thesis ...