• Large-scale comparative bioinformatics analyses

  Chatzou, Maria, 1985- (Universitat Pompeu Fabra, 2016-11-07)

  One of the main and most recent challenges of modern biology is to keep-up with growing amount of biological data coming from next generation sequencing technologies. Keeping up with the growing volumes of experiments will ...
• Understanding interactions between EBV and human genomic variation

  Mandage, Rajendra, 1984- (Universitat Pompeu Fabra, 2018-01-12)

  The EBV has been linked to multiple human disease phenotypes and has been associated with cancers and other infections. Recently single gene analysis and genome-wide analysis studies have been exploited to uncover the human ...
• The structure-function relationships underlying Drosophila larval chemotaxis

  Tastekin, Ibrahim, 1986- (Universitat Pompeu Fabra, 2017-01-16)

  The Drosophila larva is an excellent model organism to study the neural correlates of behavior. It possesses a tractable yet complex nervous system that is capable of integrating and transforming multimodal sensory stimuli ...
• Identification and characterization of a novel population of memory B cells in the human intestine

  Comerma Blesa, Laura, 1983- (Universitat Pompeu Fabra, 2016-07-12)

  We found that IgM+IgD- memory (ME-M) B cells formed a large reservoir of intestinal antigen-selected IgM+ lymphocytes distinct from antigen-naïve IgM+ lymphocytes. Human ME-M B cells colonized the intestine early in life, ...
• Unveiling new molecular Opisthokonta diversity : A perspective from evolutionary genomics

  López Escardó, David, 1988- (Universitat Pompeu Fabra, 2018-01-15)

  Opisthokonta is an eukaryotic supergroup that contains Metazoa, Fungi and their unicellular relatives. Therefore, this group provides an ideal framework to study distinct unicellular-multicellular transitions, among them, ...
• Cooperative interactions of stem and niche cells during skeletal muscle regeneration: role of IL-6 signaling

  Guerra Badell, Joana, 1986- (Universitat Pompeu Fabra, 2016-10-13)

  Adult skeletal muscle has a remarkable capacity of self-repairing after damage. The cellular communication processes and mediator molecules in the regenerative microenvironment that control muscle stem cell functions are ...
• Correlation between cognitive phenotype, neural morphology and molecular alterations in mouse models of Williams-Beuren syndrome : new therapeutic approaches

  Borralleras Fumaña, Cristina, 1988- (Universitat Pompeu Fabra, 2016-07-15)

  Williams-Beuren syndrome (WBS) is a rare neurodevelopmental disorder caused by a heterozygous deletion of 26-28 contiguous genes in the 7q11.23 region. So far, a great deal of attention has been focused on its unique and ...
• RANK signaling, a master regulator of mammary stemness and cancer : characterization of RANK and RANKL pathway stem cell fate, tumorigenesis and metastasis

  Pellegrini, Pasquale, 1983- (Universitat Pompeu Fabra, 2014-04-10)

  RESUME RANK signaling is essential for mammary gland development and progesterone induced tumorigenesis. Here we show that RANK controls mammary stem cell fate; increased RANK signaling results in accumulation of stem and ...
• INO80 complex regulates the G1-to-S transcriptional wave through MBF

  Knezevic, Iva, 1984- (Universitat Pompeu Fabra, 2015-07-17)

  In eukaryotic cells a key regulatory step of cell cycle occurs in late G1, which has been termed “Start” in yeast cells. At this point, cells determine whether they will go to through a new round of proliferation, or choose ...
• The role of the g-TuRC subunit GCP8 in microtubule regulation and cytoskeleton organization

  Klischies, Sabine, 1985- (Universitat Pompeu Fabra, 2015-07-15)

  Microtubules (MTs) are part of the cytoskeleton in eukaryotic cells and are nucleated by the -tubulin ring complex (TuRC), at the centrosome, which is also called the MTOC (microtubule organizing centers). The subunit ...
• Next generation of informatics tools for big data analytics in drug discovery

  Carrascosa Baena, María Carmen, 1972- (Universitat Pompeu Fabra, 2018-03-20)

  El paradigma clàssic on un medicament interacciona amb un únic target biològic vinculat a una malaltia es posa en dubte. Actualment es reconeix que un medicament interacciona amb múltiples targets biològics i que aquests ...
• Genetic variation and complex rearrangements in Autism Spectrum Disorders: implications for genetic counseling

  Codina i Solà, Marta, 1988- (Universitat Pompeu Fabra, 2016-07-14)

  The etiology of Autism Spectrum Disorders (ASD) remains unknown for most of the cases, in spite of its strong genetic component. A greater knowledge of its genetic basis would result in many benefits, including specific ...
• Antioxidants and PPARγ agonists protect the mitochondria of hippocampal neurons from neurodegenerative processes

  Godoy Zeballos, Juan Alejandro, 1959- (Universitat Pompeu Fabra, 2018-06-29)

  Las mitocondrias y su función metabólica cambian con el envejecimiento y pueden ser el factor más importante en el desarrollo de diferentes enfermedades neurodegenerativas relacionadas con la edad, incluida la enfermedad ...
• Comparative transcriptomics of hemimetabolan and holometabolan metamorphosis

  Ylla Bou, Guillem, 1990- (Universitat Pompeu Fabra, 2018-01-24)

  The evolutionary success of insects was particularly shaped by the innovation of the metamorphosis, especially by the transition from hemimetaboly to holometaboly. The mechanisms underlying this evolutionary transition ...
• El Artista como obra: formas de autoproducción online y offline en el arte contemporáneo 2000-2006, Barcelona - Berlín

  Pizà Airas, Sira (Universitat Pompeu Fabra, 2017-01-13)

  Esta investigación parte del análisis crítico de obras de arte contemporáneo que cuestionan la definición de la labor del artista, su estatus en una estructura de producción, y la naturaleza de su trabajo, a través de ...
• Estudio en torno a la palabra "Dieu" (Dios) en la obra escrita de Valère Novarina: Aspectos de "teatrología sacramental" en el contexto de sus textos para teatro y sus reflexiones teóricas

  Loaiza Zuluaga, Luis Fernando (Universitat Pompeu Fabra, 2018-01-11)

  La obra escrita de Valère Novarina ofrece una novedosa visión del teatro desde una perspectiva mística y teológica que se nutre de diversas fuentes de la tradición teatral y religiosa. Sus principales textos para teatro ...
• Estructura y función de las preguntas de comprensión crítica en los libros de texto de educación secundaria

  Zarate Pérez, Adolfo (Universitat Pompeu Fabra, 2018-06-26)

  La presente investigación analiza la estructura y función de las preguntas de comprensión crítica en los libros de texto de educación secundaria en el Perú. La investigación sigue una metodología descriptiva-hermenéutica, ...
• El Parlache como elemento evocador de la oralidad ficcional en la novela Rosario Tijeras, de Jorge Franco: las traducciones al alemán y al inglés

  Sánchez García, María Clemencia (Universitat Pompeu Fabra, 2018-06-25)

  El objetivo de este trabajo es investigar cómo se evoca la realidad del habla en la novela Rosario Tijeras, del colombiano Jorge Franco, y sus traducciones al alemán y al inglés. En esta novela negra, el autor recurre a ...
• Cochlear implantation modeling and functional evaluation considering uncertainty and parameter variability

  Mangado López, Nerea (Universitat Pompeu Fabra, 2017-11-16)

  Recent innovations in computational modeling have led to important advances towards the development of predictive tools to simulate and optimize surgery outcomes. This thesis is focused on cochlear implantation surgery, ...
• Assessment of depression in the adult general population using self-reported measures : Psychometric approaches for screening and severity appraisal

  Vilagut Saiz, Gemma, 1975- (Universitat Pompeu Fabra, 2017-01-20)

  This thesis provides evidence on the validity and diagnostic accuracy of generic and specific self-reported measures, developed from different psychometric approaches, to assess depression in the general population. First, ...

Mostra'n més