• Functional analysis of the extraproteasomal ubiquitin receptor Dsk2/UBQLN in Drosophila and human cells

  Di Mauro, Gianmarco, 1985- (Universitat Pompeu Fabra, 2019-02-28)

  Dsk2/UBQLN is a conserved extraproteasomal ubiquitin receptor that has been widely described as a protein involved in the ubiquitin proteasome pathway. In Drosophila, this protein has been recently reported in a non-proteolitic ...
• Big data, poder y libertad. Sobre el impacto social y político de la vigilancia masiva

  Suárez Gonzalo, Sara (Universitat Pompeu Fabra, 2019-12-16)

  Esta tesis doctoral reflexiona sobre el impacto social y político de la explotación de datos masivos a nivel europeo. Cumple dos objetivos principales. En primer lugar, define el contexto general en el que se produce esta ...
• Revealing local information : Identification of salient functional brain links in resating state brain

  Sengupta, Pallabi, 1991- (Universitat Pompeu Fabra, 2018-02-23)

  Communication amongst various regions of our brain makes it possible for us to perform a wide array of cognitive tasks. To capture these communications at a local level has remained challenging in the field of neuroimaging ...
• Image analysis and deep learning to support endovascular repair of abdominal aortic aneurysms

  López-Linares, Karen (Universitat Pompeu Fabra, 2019-06-11)

  An abdominal aortic aneurysm (AAA) is a focal dilation of the aorta that may lead to its rupture. The most common treatment for AAAs is endovascular aneurysm repair (EVAR). EVAR implies lifelong postoperative surveillance ...
• Dinámica del léxico en las Constituciones españolas

  Demol, Ségolène (Universitat Pompeu Fabra, 2020-01-31)

  El objetivo principal es realizar un estudio contrastivo del léxico de tres textos constitucionales de la historia de España: la Constitución liberal de 1812, la Constitución republicana de 1931 y la Constitución actual ...
• DNA methylation and its relationship with lifestyle, environmental and cardiovascular risk factors

  Sayols Baixeras, Sergi, 1988- (Universitat Pompeu Fabra, 2019-02-18)

  La malaltia cardiovascular, que és primera causa de mortalitat al món, com a fenotip complex depèn tant dels factors ambientals com dels genètics. Les variants genètiques comunes expliquen un 15-20% de l’heretabilitat de ...
• Modelling spatiotemporal cell regulation

  Martínez Corral, Rosa, 1991- (Universitat Pompeu Fabra, 2018-09-28)

  In this Thesis we have studied how dynamics and space modulate cellular behaviour, by means of mathematical modelling of particular biological examples. At the single cell level, we show how pulsatile input signals can be ...
• The Good, the bad, and the hairy : Comparative genomics of great apes from the point of view of human cancer

  Heredia Genestar, José María, 1985- (Universitat Pompeu Fabra, 2020-01-28)

  La mutació és un procés essencial per l’evolució, tot i que també té un rol important tant en el càncer com en altres malalties. Les mutacions no s’acumulen uniformement al llarg del genoma i la seva presència es veu ...
• The Role of cross-modal semantic interactions in real-world visuo-spatial attention

  Kvasova, Daria, 1989- (Universitat Pompeu Fabra, 2020-02-13)

  In our everyday life we must effectively orient attention to relevant objects and events in multisensory environments. The impact of cross-modal links for attention orienting to spatial and temporal cues has been widely ...
• Schlafen 12, a novel HIV restriction factor involved in latency

  Smutná, Katarína, 1991- (Universitat Pompeu Fabra, 2019-02-18)

  The process of HIV latency establishment and maintenance is not clearly understood. Homeostatic proliferation (HSP) is a major mechanism by which long-lived naive and memory CD4 T cells are maintained in vivo. HSP also ...
• Understanding dog breed copy number differences in the framework of gray wolf copy number variation

  Serres Armero, Aitor, 1992- (Universitat Pompeu Fabra, 2020-02-03)

  L’estudi de la variació estructural complementa l’estudi de la variació de seqüència per revelar les complexitats de la variació fenotípica. Els gossos són l’espècie domesticada amb més variació fenotípica que existeix ...
• Development and validation of pharmacoinformatic similarity-based tools for safety assessment of chemicals

  Pinto Gil, Kevin, 1987- (Universitat Pompeu Fabra, 2020-01-31)

  Despite the investment of vast amounts of money over the last decades, drug discovery and development remains an inefficient process, which can be stopped at different steps, leading to the loss of all resources invested. ...
• RNA-binding and prion domains : The Yin and Yang of phase separation

  Lorenzo Gotor, Nieves, 1984- (Universitat Pompeu Fabra, 2020-01-24)

  Biomolecular condensates act as indispensable membrane-less organelles for intracellular organization and regulation of biochemical reactions. Proteins and RNAs are known to phase separate into condensates, however the ...
• Application of genome assembly methods to human and non-human primate genomics

  Kuderna, Lukas, 1989- (Universitat Pompeu Fabra, 2020-01-24)

  Genomic analyses are at the center of contemporary biology. These studies heavily rely on reference genome assemblies, yet those are typically highly fragmented. Having accurate representations of complex genomes, or parts ...
• Computational characterization of protein-RNA interactions and implications for phase separation

  Armaos, Alexandros, 1989- (Universitat Pompeu Fabra, 2020-01-23)

  Despite what was previously considered, the role of RNA is not only to carry the genetic information from DNA to proteins. Indeed, RNA has proven to be implicated in more complex cellular processes. Recent evidence suggests ...
• La Inseguridad residencial por motivos económicos y su relación con la salud

  Vásquez-Vera, Hugo, 1982- (Universitat Pompeu Fabra, 2020-02-06)

  La inseguridad residencial por motivos económicos es un grave problema de salud pública que ha aumentado en los últimos años en el Estado español. Incluye diversas situaciones como el no poder pagar el alquiler o la hipoteca, ...
• La Necropoli fenicia di Khaldé (Beirut, Libano): analisi della documentazione inedita degli scavi di Roger Saidah, campagne del 1961 e 1962

  Mura, Barbara (Universitat Pompeu Fabra, 2016-02-08)

  This thesis is focused on the the recovery of the materials and of the documentation from Roger Saidah’s excavations in the Phoenician necropolis of Khaldé (Beirut, Lebanon). The necropolis was extensively excavated during ...
• Study of alternative approaches to modulate the endocannabinoid system : focus on memory and motor coordination

  Martínez Torres, Sara, 1992- (Universitat Pompeu Fabra, 2019-12-12)

  The endocannabinoid system (ECS) is an endogenous neuromodulatory system widely expressed in the central nervous system and peripheral organs, where it fine-tunes numerous physiological functions. The ECS is under study ...
• Chromosomal instability : interplay between proteotoxic and metabolic stress

  Joy, Jery, 1992- (Universitat Pompeu Fabra, 2020-02-03)

  Chromosomal Instability (CIN) and associated aneuploidy are salient features of the majority of human solid tumors. In the Drosophila epithelial model of CIN, the generation of highly aneuploid karyotypes drive cell ...
• Factors associated to juvenile hormone signalling during embryonic and postembryonic development in the cockroach Blattella germanica

  Fernández Nicolás, Ana, 1988- (Universitat Pompeu Fabra, 2018-01-30)

  In the present thesis, we have studied the metamorphosis of the cockroach Blattella germanica, focusing on two main periods of development, the embryonic and the postembryonic. In the embryonic development, we have studied ...

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