• Capture and identification of carbohydrate-binding proteins by SPR and CREDEX-MS

  Jiménez-Castells, Carmen, 1982- (Universitat Pompeu Fabra, 2010-12-20)

  Carbohydrate-binding proteins of non-immunological origin -lectins- have been recognized over the last decades as decisive players in numerous biological processes, ranging from cellcell communication, fertilization, ...
• Role of EphB receptors in intestinal epithelial cell positioning and colorectal cancer progression

  Cortina Duran, Carme (Universitat Pompeu Fabra, 2009-09-10)

  In the intestinal epithelium, Wnt signaling drives the expression of the genes encoding tyrosine kinase receptors EphB2 and EphB3 and represses the expression of their membrane-tethered ligands, ephrin-Bs. Eph-ephrin ...
• Development of xenobiotic-free conditions towards the generation and propagation of clinically-safe human pluripotent stem cells

  Rodríguez Pizà, Ignasi (Universitat Pompeu Fabra, 2010-07-05)

  Les cèl·lules mare embrionàries humanes (hESC) i més recentment les cèl·lules de pluripotència induïda (iPSC) representen una oportunitat sense precedents per al desenvolupament de noves estratègies terapèutiques per ...
• Regulation of natural killer and cd4+T cell function by NKG2 C-type lectin-like receptors

  Sáez Borderias, Andrea (Universitat Pompeu Fabra, 2009-02-20)

  This work is centered on the study of the NKG2 C-type lectin-like receptors on NK and CD4+T cells. We provide evidence supporting that CD4+T cells specific for Human Cytomegalovirus (HCMV) may express different NK cell ...
• Homology modeling and structural analysis of the antipsychotic drugs receptorome

  López Muñoz, Laura (Universitat Pompeu Fabra, 2010-06-22)

  Classically it was assumed that the compounds with therapeutic effect exert their action interacting with a single receptor. Nowadays it is widely recognized that the pharmacological effect of most drugs is more complex ...
• Duplicacions segmentàries a la regió cromosòmica humana 8P23.1: evolució i expansió d'una nova família gènica

  Bosch Pages, Nina (Universitat Pompeu Fabra, 2008-12-19)

  Les duplicacions segmentàries (DSs), o també anomenades duplicons o Low copy Repeats (LCRs), són regions de coma mínim 1 kb amb un alt nivell d'identitat (>90%), que estan presents almenys dues vegades en el genoma. La ...
• Localization and regulation of trpv4 channels in CILIATED epithelia

  Lorenzo Moldero, Ivan (Universitat Pompeu Fabra, 2008-07-24)

  La neteja del moc i dels patògens dels pulmons, i el transport de gàmets i embrions en els òrgans reproductius de les femelles són funcions clau en els epitelis ciliats, tals com aquells que es troben presents en les vies ...
• Study of Dyrk1a kinase in central nervous systems development: implication in mouse retina development

  Laguna Tuset, Ariadna (Universitat Pompeu Fabra, 2008-12-18)

  El gen DYRK1A es troba situat en una regió del cromosoma 21 humà que s'ha associat a alteracions en el neurodesenvolupament. Aquest treball mostra com canvis en la dosis gènica de Dyrk1A en el ratolí causen una alteració ...
• Modeling of 5-HT2A and 5-HT2C receptors and of theirs complexes with actual and potential antypsichotic drugs

  Dezi, Cristina (Universitat Pompeu Fabra, 2008-01-28)

  La presente tesis "Modelling of 5-HT2A and 5-HT2C receptors and of their complexes with actual and potential antipsychotic drugs" tiene como objetivo de profundizar los conocimientos actuales sobre el mecanismo de acción ...
• Development of high-performance algorithms for a new generation of versatile molecular descriptors. The Pentacle software

  Durán Alcaide, Ángel (Universitat Pompeu Fabra, 2010-03-04)

  The work of this thesis was focused on the development of high-performance algorithms for a new generation of molecular descriptors, with many advantages with respect to its predecessors, suitable for diverse applications ...
• ICAT: a novel Ptf 1A/P48 partner that modulates acinar expression

  Campos, Maria Luisa Morais Sarmento de (Universitat Pompeu Fabra, 2010-04-09)

  Ptf1a/p48 is a pancreas specific bHLH transcription factor that is required at early stages of embryonic development for pancreas formation and, during adulthood, for the proper exocrine pancreatic function. P48 also exerts ...
• Detecció de l'administració de 17(beta)-nandrolona en animals

  Roig Virgili, Meritxell (Universitat Pompeu Fabra, 2010-12-17)

  17β-nandrolone (17βN) is illegally used in sport and in livestock as a growth promoter.17βN and some of their metabolites have been described as endogenous compounds in some animals, such as adult boars and entire male ...
• Detecció del consum d'agents anabolitzants en humans: estratègies alternatives de preparació de mostres i anàlisi instrumental

  Marcos del Águila, Josep (Universitat Pompeu Fabra, 2004-06-28)

  Los agentes anabolizantes prohibidos por la Comisión Médica del Comité Olímpico Internacional (COI) deben estar ausentes en las muestras de orina objeto de análisis. El límite de detección está condicionado por la ...
• Factores pronósticos en el latigazo cervical

  Pleguezuelos Cobo, Eulogio (Universitat Pompeu Fabra, 2011-12-12)

  Múltiples revisiones científicas han intentado determinar los factores pronósticos en la evolución del latigazo cervical sin llegar a un consenso. Nuestros resultados se han obtenido tras 8 años de estudio en pacientes controlados ...
• BeFree : a text mining system for the extraction of biomedical information from literature

  Bravo Serrano, Àlex, 1984- (Universitat Pompeu Fabra, 2016-11-28)

  Current biomedical research needs to leverage the large amount of information reported in scientific publications. Automated text processing, commonly known as text mining, has become an indispensable tool to identify, ...
• Performance indicators in academic radiology departments in the United States

  Ondategui Parra, Silvia (Universitat Pompeu Fabra, 2008-04-21)

  PURPOSE: To determine the management performance indicators most frequently utilized in academic radiology departments in the United States. MATERIALS AND METHODS: This investigation met the criteria for an exemption from ...
• Regulatory mechanisms of c-Myc and their role in Acute Myeloid Leukemia

  Uribesalgo Micàs, Iris (Universitat Pompeu Fabra, 2010-11-24)

  The c-Myc transcription factor is a key player in cell homeostasis, being commonly deregulated in human carcinogenesis. In this PhD thesis we have addressed the question how regulatory mechanisms restrain the oncogenic ...
• Cracking the code of 3' ss selection in s.cerevisiae

  Meyer, Markus (Universitat Pompeu Fabra, 2010-03-26)

  The informational content of 3' splice sites is low and the mechanisms whereby they are selected are not clear. Here we enunciate a set of rules that govern their selection. For many introns, secondary structures are a key ...
• Characterization of snail1 and pten transcriptional regulation by snail1: New insights into epithelial-to-mesenchymal transition and cell resistance to apoptosis

  Escrivà Izquierdo, María (Universitat Pompeu Fabra, 2008-06-20)

  The product of the snail1 gene (SNAIL1) is a transcriptional repressor required for triggering the epithelial-to-mesenchymal transition (EMT). SNAIL1 transcription is induced when epithelial cells are forced to acquire a ...
• Reincorporación al trabajo después de un epidodio de incapacidad temporal por contingencia común de larga duración. Análisis de los factores pronóstico.

  Sampere Valero, Maite (Universitat Pompeu Fabra, 2011-11-25)

  La incapacidad temporal por contingencia común (ITcc) representa un elevado coste social. Cualquier esfuerzo para desarrollar políticas orientadas a mejorar la gestión de los episodios de ITcc y facilitar el retorno al ...

View more