• RNA-binding and prion domains : The Yin and Yang of phase separation

  Lorenzo Gotor, Nieves, 1984- (Universitat Pompeu Fabra, 2020-01-24)

  Biomolecular condensates act as indispensable membrane-less organelles for intracellular organization and regulation of biochemical reactions. Proteins and RNAs are known to phase separate into condensates, however the ...
• The Good, the bad and the hairy : Comparative genomics of great apes from the point of view of human cancer

  Heredia Genestar, José María, 1985- (Universitat Pompeu Fabra, 2020-01-28)

  La mutació és un procés essencial per l’evolució, tot i que també té un rol important tant en el càncer com en altres malalties. Les mutacions no s’acumulen uniformement al llarg del genoma i la seva presència es veu ...
• Application of genome assembly methods to human and non-human primate genomics

  Kuderna, Lukas, 1989- (Universitat Pompeu Fabra, 2020-01-24)

  Genomic analyses are at the center of contemporary biology. These studies heavily rely on reference genome assemblies, yet those are typically highly fragmented. Having accurate representations of complex genomes, or parts ...
• DNA methylation and its relationship with lifestyle, environmental and cardiovascular risk factors

  Sayols Baixeras, Sergi, 1988- (Universitat Pompeu Fabra, 2019-02-18)

  La malaltia cardiovascular, que és primera causa de mortalitat al món, com a fenotip complex depèn tant dels factors ambientals com dels genètics. Les variants genètiques comunes expliquen un 15-20% de l’heretabilitat de ...
• Schlafen 12, a novel HIV restriction factor involved in latency

  Smutná, Katarína, 1991- (Universitat Pompeu Fabra, 2019-02-18)

  The process of HIV latency establishment and maintenance is not clearly understood. Homeostatic proliferation (HSP) is a major mechanism by which long-lived naive and memory CD4 T cells are maintained in vivo. HSP also ...
• Computational characterization of protein-RNA interactions and implications for phase separation

  Armaos, Alexandros, 1989- (Universitat Pompeu Fabra, 2020-01-23)

  Despite what was previously considered, the role of RNA is not only to carry the genetic information from DNA to proteins. Indeed, RNA has proven to be implicated in more complex cellular processes. Recent evidence suggests ...
• La Inseguridad residencial por motivos económicos y su relación con la salud

  Vásquez-Vera, Hugo, 1982- (Universitat Pompeu Fabra, 2020-02-06)

  La inseguridad residencial por motivos económicos es un grave problema de salud pública que ha aumentado en los últimos años en el Estado español. Incluye diversas situaciones como el no poder pagar el alquiler o la hipoteca, ...
• La Necropoli fenicia di Khaldé (Beirut, Libano): analisi della documentazione inedita degli scavi di Roger Saidah, campagne del 1961 e 1962

  Mura, Barbara (Universitat Pompeu Fabra, 2016-02-08)

  This thesis is focused on the the recovery of the materials and of the documentation from Roger Saidah’s excavations in the Phoenician necropolis of Khaldé (Beirut, Lebanon). The necropolis was extensively excavated during ...
• Study of alternative approaches to modulate the endocannabinoid system : focus on memory and motor coordination

  Martínez Torres, Sara, 1992- (Universitat Pompeu Fabra, 2019-12-12)

  The endocannabinoid system (ECS) is an endogenous neuromodulatory system widely expressed in the central nervous system and peripheral organs, where it fine-tunes numerous physiological functions. The ECS is under study ...
• Chromosomal instability : interplay between proteotoxic and metabolic stress

  Joy, Jery, 1992- (Universitat Pompeu Fabra, 2020-02-03)

  Chromosomal Instability (CIN) and associated aneuploidy are salient features of the majority of human solid tumors. In the Drosophila epithelial model of CIN, the generation of highly aneuploid karyotypes drive cell ...
• Factors associated to juvenile hormone signalling during embryonic and postembryonic development in the cockroach Blattella germanica

  Fernández Nicolás, Ana, 1988- (Universitat Pompeu Fabra, 2018-01-30)

  In the present thesis, we have studied the metamorphosis of the cockroach Blattella germanica, focusing on two main periods of development, the embryonic and the postembryonic. In the embryonic development, we have studied ...
• Dynamical aspects of the regulation of bacterial proliferation

  Galera Laporta, Letícia, 1985- (Universitat Pompeu Fabra, 2019-02-08)

  Bacterial proliferation has been studied for more than 100 years, but our knowledge of the mechanisms that control its dynamical aspects is still very limited. In this Thesis we have studied, at both singlecell and population ...
• Protección a la maternidad en Chile : efectividad y equidad en el acceso : Evaluación de la Ley 20.545 del año 2011

  Delgado Becerra, Orozimba Iris, 1958- (Universitat Pompeu Fabra, 2019-02-07)

  Conciliar la maternidad y el trabajo, y avanzar en la equidad de género, son temas de creciente interés global que están generando políticas innovadoras, sin embargo, apenas conocemos su impacto. Internacionalmente, las ...
• Insights into the adaptative history of African human populations from whole-genome sequence data

  Walsh Capdevila, Sandra, 1991- (Universitat Pompeu Fabra, 2019-12-18)

  Africa is the origin source of modern humans. Despite that African populations harbor the highest levels of genetic diversity worldwide, they remain underrepresented in genetic studies. Therefore, in order to fully understand ...
• Tan lejos, tan cerca: la traducción y circulación de literatura latinoamericana en China

  Chen, Yehua (Universitat Pompeu Fabra, 2020-01-28)

  Esta tesis investiga los criterios y mecanismos aplicados para la selección textual en la traducción de la literatura latinoamericana al chino y la imagen sobre América Latina que se ha construido por su producción literaria, ...
• Role of the protein quality control system in basal and stress conditions in fission yeast

  Marte, Luis, 1990- (Universitat Pompeu Fabra, 2020-01-31)

  Proteostasis is the proper homeostasis of the concentration and the molecular structure of the proteins, which preserves the integrity of the proteome. Proteo-stasis is constantly challenged by intrinsic and extrinsic ...
• Understanding the immunomodulatory role of PARP proteins in the response against tumors

  Moreno Lama, Lucía, 1993- (Universitat Pompeu Fabra, 2020-01-16)

  Los inhibidores de PARP han surgido como nuevas terapias basadas en el papel essencial de las Poly (ADP-ribosa) polimerasas PARP-1 y PARP-2 en la respuesta a daño en el DNA, explotando el efecto de las mismas en la célula ...
• A Multivarite approach to study the genetic determinants of phenotypic traits

  Garrido Martín, Diego, 1992- (Universitat Pompeu Fabra, 2020-01-30)

  We have developed an efficient and reproducible pipeline for the identification of genetic variants affecting splicing (splicing quantitative trait loci or sQTLs), based on an approach that captures the intrinsically ...
• DNA methylation, cardiovascular risk and myocardial infarction : an epigenome-wide approach

  Fernández Sanlés, Alba (Universitat Pompeu Fabra, 2020-01-31)

  Cardiovascular diseases are a major challenge for public health. DNA methylation is a mechanism regulating gene expression, and it is linked to complex diseases and related traits. Therefore, it is a potential source of ...
• Qualitative analysis: viewing, consumption and usability of SVO

  Glass, James (Universitat Pompeu Fabra, 2020-01-24)

  This research examines Subscription Video On-Demand (SVOD) using Netflix as one of the main examples that has seen a dramatic increase in usage in recent years compared to the traditional way of viewing content through ...

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