• Linking cell dynamics with coexpression networks to characterize key events in chronic virus infection

  Riera Domínguez, María Graciela (Universitat Pompeu Fabra, 2018-12-10)

  The host immune response against infection requires the coordinated action of many diverse cell subsets that dynamically adapt to a pathogen threat. Due to the complexity of such a response, most immunological studies have ...
• Study of Dyrk1a kinase in central nervous systems development: implication in mouse retina development

  Laguna Tuset, Ariadna (Universitat Pompeu Fabra, 2008-12-18)

  El gen DYRK1A es troba situat en una regió del cromosoma 21 humà que s'ha associat a alteracions en el neurodesenvolupament. Aquest treball mostra com canvis en la dosis gènica de Dyrk1A en el ratolí causen una alteració ...
• Natural antisense transcripts control LEF1 gene expression

  Aparicio i Prat, Estel (Universitat Pompeu Fabra, 2014-02-07)

  Non-coding RNA functions are emerging in the recent years. In this thesis we describe a Natural Antisense Transcript (NAT) that controls the expression of LEF1 transcriptional factor. This LEF1 NAT is transcribed from a ...
• The Aurora B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress

  Amaral, Nuno (Universitat Pompeu Fabra, 2016-01-22)

  La coordinació de la citocinesis amb la segregació cromosòmica és essencial per mantenir l’estabilitat cromosòmica durant la proliferació cel•lular. Tant en llevat com en cèl•lules animals, els ponts de cromatina en anafase ...
• The Impact of polypharmacology on chemical biology

  Antolín Hernández, Albert (Universitat Pompeu Fabra, 2014-10-09)

  There is now ample evidence that drugs have biologically relevant interactions with more than one protein, a behavior that is commonly referred to as polypharmacology. This finding is starting to have a true impact on the ...
• Effectiveness of an intervention of urban training in patients with chronic obstructive pulmonary disease (COPD): a randomised controlled trial

  Arbillaga Etxarri, Ane (Universitat Pompeu Fabra, 2016-12-20)

  High levels of physical activity have been related to better prognosis in patients with chronic obstructive pulmonary disease (COPD). However, so far no interventions have proven effective to modify physical activity in ...
• Intrinsic and environmental influences on DNA methylation and gene expression in fish

  Anastasiadi, Dafni (Universitat Pompeu Fabra, 2016-11-14)

  Epigenetic mechanisms, influenced by intrinsic and environmental factors are crucial for the regulation of gene expression and, ultimately, the phenotype. The European sea bass is used as a model to study these influences ...
• Characterization of the role of the CPEB family of RNA-binding proteins in neurodegeneration

  Anta Rodríguez, Héctor (Universitat Pompeu Fabra, 2016-12-15)

  Alzheimer’s disease (AD) is the most common type of dementia in the elderly. It is associated to a progressive loss of memory, problems in learning and behaviour changes. This disease is characterized by the accumulation ...
• The Role of Msi2 in adult and embryonic hematopoiesis

  Andrés Aguayo, Luisa de (Universitat Pompeu Fabra, 2017-05-05)

  The life-long production of blood cells is enabled by hematopoietic stem and progenitor cells (HSPC) residing in the bone marrow. An understanding of the genes that control how HSPCs work to sustain the continued production ...
• Characterization of the human sperm centrosome and its role in (in)fertility

  Amargant i Riera, Farners (Universitat Pompeu Fabra, 2018-07-19)

  The centrosome is an essential organelle for the development of a new organism in animals. Upon fertilization the spermatozoon enters into the oocyte providing its basal body that converts into the first centrosome of the ...
• Bonobo evolution : from the perspective of genomes

  Han, Sojung (Universitat Pompeu Fabra, 2019-10-16)

  Bonobos are an interesting species to study due to their unique evolutionary features such as a peaceful social nature and hypersexual behavior. The prolonged exaggerated sexual swelling in females is a notable difference ...
• Time-resolved systems analysis of virus infection fate regulation

  Pedragosa Marín, Mireia (Universitat Pompeu Fabra, 2018-03-21)

  The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus - immune system interaction with either an efficient effector response and virus elimination or an alleviated immune ...
• The evolutionary landscape of the DNA damage response network: a computational approach

  Arcas Mantas, Aida (Universitat Pompeu Fabra, 2013-04-25)

  The DNA Damage response is a crucial signaling network that preserves genome integrity. This network is an ensemble of distinct but often overlapping sub-networks, where participating components exert different functions ...
• Effect of DYRK1A dose reduction on the transcriptome of the developing mouse cerebral cortex : implications in gliogenesis

  Balducci, Elisa (Universitat Pompeu Fabra, 2012-02-24)

  Cerebral cortex is essential to exert the highest functions in mammals. Understanding the developmental processes that underlie the generation and functionality of cortical cell populations represents a mayor issue in ...
• Electra: mite i recreació en el teatre català contemporani

  Tomàs Albina, Alba (Universitat Pompeu Fabra, 2017-03-02)

  Aquesta tesi doctoral tracta de les recreacions del mite d’Electra en el teatre català contemporani en relació amb les versions clàssiques, tot tenint en compte, també, determinades reescriptures contemporànies d’altres ...
• Exploring through prototyping embodied interaction design developing systems for mathematics learning for children with visual impairments and without

  Marichal Baráibar, Sebastián (Universitat Pompeu Fabra, 2020-06-09)

  In the last decades new interaction paradigms have emerged: Tangible User Interfaces, ubiquitous computing, wearable devices, mixed- reality among others. Such paradigms extended the user interface beyond the keyboard and ...
• Los Órdenes regionales en Oriente Medio y el Norte de África (1945-2011)

  Quero Arias, Jordi (Universitat Pompeu Fabra, 2020-10-02)

  La tesis doctoral Los órdenes regionales en Oriente Medio y el Norte de África (1945-2011) analiza el conjunto de normas e instituciones primarias que han regulado el comportamiento de los actores internacionales del ...
• From pixels to particles: multi-physics meshless model of the heart

  Lluc Álvarez, Èric (Universitat Pompeu Fabra, 2019-10-21)

  The functioning of the heart, which main role is pumping blood to the rest of the body, is the result of a complex combination of multi-scale physical processes from the molecular to the tissue level. The predominance of ...
• La Tentativa y el nacimiento de la ciencia penal europea: bases para una reconstrucción contemporánea

  Garcóa de la Torre, Héctor (Universitat Pompeu Fabra, 2020-10-02)

  La presente tesis doctoral pone de manifiesto la necesidad de revisar el concepto de tentativa con el que trabaja la dogmática jurídico-penal contemporánea. Buena parte de los problemas que se discuten en ese ámbito son, ...
• Strategy selection and function learning in decision making

  Stojić, Hrvoje (Universitat Pompeu Fabra, 2017-01-17)

  This thesis consists of three studies investigating the strategy selection problem and the role of function learning in human decision making. Chapter 1 examines how people learn which decision strategy to use when ...

View more