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Effectiveness of the physical activity intervention program in the PREDIMED-Plus study: a randomized controlled trial

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dc.contributor.author Schröder, Helmut, 1958-
dc.contributor.author Cárdenas Fuentes, Gabriela, 1985-
dc.contributor.author Goday Arno, Alberto
dc.contributor.author Salas-Salvadó, Jordi
dc.contributor.author REDIMED-Plus investigators
dc.date.accessioned 2019-05-22T07:31:25Z
dc.date.available 2019-05-22T07:31:25Z
dc.date.issued 2018
dc.identifier.citation Schröder H, Cárdenas-Fuentes G, Martínez-González MA, Corella D, Vioque J, Romaguera D. et al. Effectiveness of the physical activity intervention program in the PREDIMED-Plus study: a randomized controlled trial. Int J Behav Nutr Phys Act. 2018 Nov 13;15(1):110. DOI: 10.1186/s12966-018-0741-x
dc.identifier.issn 1479-5868
dc.identifier.uri http://hdl.handle.net/10230/37256
dc.description.abstract BACKGROUND: The development and implementation of effective physical activity (PA) intervention programs is challenging, particularly in older adults. After the first year of the intervention program used in the ongoing PREvención con DIeta MEDiterránea (PREDIMED)-Plus trial, we assessed the initial effectiveness of the PA component. METHODS: PREDIMED-Plus is an ongoing randomized clinical trial including 6874 participants randomized to an intensive weight-loss lifestyle intervention based on an energy-restricted Mediterranean diet (MedDiet), physical activity promotion and behavioral support and to a control group using MedDiet recommendations but without calorie restriction or PA advice. Body mass index (BMI) and waist circumference (WC) are measured by standard clinical protocols. Duration and intensity of PA is self-reported using the validated REGICOR Short Physical Activity Questionnaire. The primary endpoint of the PREDIMED-Plus trial is a combined cardiovascular outcome: myocardial infarction (acute coronary syndromes with positive troponin test), stroke, or cardiovascular mortality. The present study involved secondary analysis of PA data (n = 6059; mean age 65 ± 4.9 years) with one-year changes in total, light, and moderate-to-vigorous PA within and between intervention groups as the outcome. Generalized estimating equation models were fitted to evaluate time trends of PA, BMI, and WC within groups and differences between intervention and control groups. RESULTS: After 12 months, average daily MVPA increased by 27.2 (95%CI 5.7;48.7) METs-min/day and 123.1 (95%CI 109.7-136.6) METs-min/day in the control and intervention groups, respectively. Total-PA, light-PA, and MVPA increased significantly (p < 0.01) in both groups. A significant (p < 0.001) time*intervention group interaction was found for Total-PA and MVPA, meaning the PA trajectory over time differed between the intervention and control groups. Age, sex, education level, and BMI did not moderate the effectiveness of the PA intervention. BMI and WC decreased significantly with increasing MVPA, compared with participants who reported no changes in MVPA. CONCLUSION: After one year of follow-up, the PREDIMED-Plus PA intervention has been effective in increasing daily PA in older adults. TRIAL REGISTRATION: Retrospectively registered at the International Standard Randomized Controlled Trial ( http://www.isrctn.com/ISRCTN89898870 ), registration date: 24 July 2014.
dc.description.sponsorship This work was supported by the Spanish Ministry of Health (Carlos III Health Institute) through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (two coordinated FIS projects led by Jordi Salas-Salvado and Josep Vidal, funded by the following grant codes: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728 PI13/01090 PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14–00696, PI14/01471, PI14/01206, PI14/01919, PI14/00853 [JV and JSS]; the European Research Council (Advanced Research Grant 2013–2018; grant number 340918) [MAMG]; Recercaixa (2013ACUP00194); the Consejería de Salud de la Junta de Andalucía (grant number PI0458/2013) and a SEMERGEN grant. None of the funding sources took part in the design, collection, analysis or interpretation of the data, or in the decision to submit the manuscript for publication. CIBERobn (Centros de Investigación Biomedica en Red: Obesidad y Nutrición), CIBEResp (Centros de Investigación Biomedica en Red: Epidemiología y Salud Publica) and CIBERdem (Centros de Investigación Biomedica en Red: Diabetes y Enfermedades Metabolicas asociadas) are initiatives of ISCIII, Madrid, Spain.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof International Journal of Behavioral Nutrition and Physical Activity. 2018 Nov 13;15(1):110
dc.rights Copyright © The Author(s). 2018. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Exercici
dc.title Effectiveness of the physical activity intervention program in the PREDIMED-Plus study: a randomized controlled trial
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1186/s12966-018-0741-x
dc.subject.keyword Body mass index
dc.subject.keyword Intervention program
dc.subject.keyword Older adults
dc.subject.keyword Physical activity
dc.subject.keyword Randomized control trial
dc.subject.keyword Waist circumference
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/340918
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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