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Metabolic flux is a determinant of the evolutionary rates of enzyme-encoding genes

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dc.contributor.author Colombo, Martino
dc.contributor.author Laayouni, Hafid, 1968-
dc.contributor.author Invergo, Brandon M., 1982-
dc.contributor.author Bertranpetit, Jaume, 1952-
dc.contributor.author Montanucci, Ludovica, 1978-
dc.date.accessioned 2019-04-11T10:41:38Z
dc.date.available 2019-04-11T10:41:38Z
dc.date.issued 2014
dc.identifier.citation Colombo M, Laayouni H, Invergo BM, Bertranpetit J, Montanucci L. Metabolic flux is a determinant of the evolutionary rates of enzyme-encoding genes. Evolution. 2014 Feb; 68(2): 605-13. DOI: 10.1111/evo.12262
dc.identifier.issn 0014-3820
dc.identifier.uri http://hdl.handle.net/10230/37094
dc.description.abstract Relationships between evolutionary rates and gene properties on a genomic, functional, pathway, or system level are being explored to unravel the principles of the evolutionary process. In particular, functional network properties have been analyzed to recognize the constraints they may impose on the evolutionary fate of genes. Here we took as a case study the core metabolic network in human erythrocytes and we analyzed the relationship between the evolutionary rates of its genes and the metabolic flux distribution throughout it. We found that metabolic flux correlates with the ratio of nonsynonymous to synonymous substitution rates. Genes encoding enzymes that carry high fluxes have been more constrained in their evolution, while purifying selection is more relaxed in genes encoding enzymes carrying low metabolic fluxes. These results demonstrate the importance of considering the dynamical functioning of gene networks when assessing the action of selection on system-level properties.
dc.description.sponsorship This research was funded by grants BFU2010-19443 (subprogram BMC) awarded by Ministerio de Ciencia y Tecnología (Spain) and by the Direcció General de Recerca, Generalitat de Catalunya (Grup de Recerca Consolidat 2009 SGR 1101). BI is supported by a FI-DGR from AGAUR, Generalitat de Catalunya (2011F1 B1 00275). LM acknowledges funding from the Juan de la Cierva Program of the Spanish Ministry of Science and Innovation (MICINN)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley-VCH Verlag
dc.rights © 2013 The Author(s). Evolution © 2013 The Society for the Study of Evolution. Evolution 68-2: 605–613
dc.subject.other Enzims -- Genètica
dc.subject.other Evolució molecular
dc.subject.other Metabolisme
dc.subject.other Genètica
dc.title Metabolic flux is a determinant of the evolutionary rates of enzyme-encoding genes
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1111/evo.12262
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2010-19443
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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