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Maintenance low dose systemic glucocorticoids have limited impact on bone strength and mineral density among incident renal allograft recipients: A pilot prospective cohort study

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dc.contributor.author Pérez-Sáez, María José
dc.contributor.author Herrera, Sabina
dc.contributor.author Prieto-Alhambra, Daniel
dc.contributor.author Vilaplana, Laia
dc.contributor.author Nogués Solan, Francesc Xavier
dc.contributor.author Vera, María
dc.contributor.author Redondo Pachón, María Dolores
dc.contributor.author Mir Fontana, M. Luisa
dc.contributor.author Güerri Fernández, Roberto
dc.contributor.author Crespo Barrio, Marta
dc.contributor.author Díez Pérez, Adolfo
dc.contributor.author Pascual Santos, Julio
dc.date.accessioned 2019-03-19T08:32:30Z
dc.date.issued 2018
dc.identifier.citation Pérez-Sáez MJ, Herrera S, Prieto-Alhambra D, Vilaplana L, Nogués X, Vera M. et al. Maintenance low dose systemic glucocorticoids have limited impact on bone strength and mineral density among incident renal allograft recipients: A pilot prospective cohort study. Bone. 2018 Nov;116:290-294. DOI: 10.1016/j.bone.2018.08.013
dc.identifier.issn 1873-2763
dc.identifier.uri http://hdl.handle.net/10230/36861
dc.description.abstract Soon after kidney transplant (KT), a decrease in parathormone and bone mineral density (BMD) occur, but little is known on the impact of KT on novel bone quality parameters including trabecular bone score (TBS) and bone material strength index (BMSi). We aimed to study BMD, TBS and BMSi in the first year after KT, in patients not treated with any bone therapy. A cohort including 36 patients underwent KT on a low-glucocorticoid-dose protocol (5 mg daily-prednisone from post-operative-day 42 onwards) and was observed for 12 months prospectively. At 3 months, phosphorus and parathormone decreased, while calcium increased. We also observed at 3 months a transient mild 2.9% bone loss at femoral neck (BMD change 0.752 ± 0.15 vs 0.730 ± 0.15; p = 0.004), but no change at either spine or total hip. Both TBS and BMSi remained stable. At 12 months, lumbar (but not total hip or femoral neck) BMD slightly decreased by 2.1% vs baseline (0.950 ± 0.15 vs 0.930 ± 0.5; p = 0.046), while TBS and BMSi remained unmodified. In KT patients on low-dose glucocorticoids and no bone therapy, there were small BMD decreases at femoral neck (at 3 months) and lumbar spine (at 12 months), but no change in either TBS or BMSi. Low-dose post-KT glucocorticoid treatment shows limited impact on bone, supporting steroid-restrictive protocols.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Bone. 2018 Nov;116:290-4
dc.rights © Elsevier http://dx.doi.org/10.1016/j.bone.2018.08.013
dc.subject.other Ronyons -- Trasplantació
dc.subject.other Ossos -- Malalties
dc.title Maintenance low dose systemic glucocorticoids have limited impact on bone strength and mineral density among incident renal allograft recipients: A pilot prospective cohort study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.bone.2018.08.013
dc.subject.keyword Bone mineral disease
dc.subject.keyword Kidney transplant
dc.subject.keyword Microindentation
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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