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A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

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dc.contributor.author Rothman, Nathaniel
dc.contributor.author Real, Francisco X.
dc.contributor.author Serra, Consol
dc.contributor.author Lloreta Trull, Josep, 1958-
dc.contributor.author Chanock, Stephen J.
dc.date.accessioned 2019-02-15T06:28:38Z
dc.date.available 2019-02-15T06:28:38Z
dc.date.issued 2010
dc.identifier.citation Rothman N, Garcia-Closas M, Chatterjee N, Malats N, Wu X, Figueroa JD et al. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet. 2010;42(11):978-84. DOI: 10.1038/ng.687
dc.identifier.issn 1061-4036
dc.identifier.uri http://hdl.handle.net/10230/36598
dc.description.abstract We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Research
dc.relation.ispartof Nature Genetics. 2010;42(11):978-84
dc.rights © Springer Nature Publishing AG. Rothman N, Garcia-Closas M, Chatterjee N, Malats N, Wu X, Figueroa JD et al. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet. 2010; 42(11):978-84. DOI 10.1038/ng.687 [http://dx.doi.org/10.1038/ng.687]
dc.title A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/ng.687
dc.subject.keyword Bladder cancer
dc.subject.keyword Genome-wide association studies
dc.subject.keyword Psychology
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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