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Dietary benzo(a)pyrene and fetal growth: effect modification by vitamin C intake and glutathione S-transferase P1 polymorphism

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dc.contributor.author Duarte Salles, Talita, 1985-
dc.contributor.author Mendez, Michelle A.
dc.contributor.author Morales, Eva
dc.contributor.author Bustamante Pineda, Mariona
dc.contributor.author Rodríguez-Vicente, Agueda
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Sunyer Deu, Jordi
dc.date.accessioned 2019-02-06T09:01:05Z
dc.date.available 2019-02-06T09:01:05Z
dc.date.issued 2012
dc.identifier.citation Duarte-Salles T, Mendez MA, Morales E, Bustamante M, Rodríguez-Vicente A, Kogevinas M et al. Dietary benzo(a)pyrene and fetal growth: effect modification by vitamin C intake and glutathione S-transferase P1 polymorphism. Environ Int. 2012;45:1-8. DOI: 10.1016/j.envint.2012.04.002
dc.identifier.issn 0160-4120
dc.identifier.uri http://hdl.handle.net/10230/36513
dc.description.abstract Background: Previous studies have reported maternal exposure to airborne polycyclic aromatic hydrocarbons (PAH), as well as DNA adducts reflecting total PAH exposure, to be associated with reduced fetal growth. The role of diet, the main source of PAH exposure among non-smokers, remains uncertain. Objective: To assess associations between birth weight, length and small size for gestational age (SGA) with maternal intakes of the genotoxic PAH benzo(a)pyrene [B(a)P] during pregnancy, exploring potential effect modification by dietary intakes of vitamin C, vitamin E, alpha- and beta-carotene, as well as glutathione S-transferase P1 (GSTP1) polymorphisms, hypothesized to influence PAH metabolism. Methods: 657 women in the INMA (Environment and Childhood) Project from Sabadell (Barcelona) were recruited during the first trimester of pregnancy. Dietary B(a)P and nutrient intakes were estimated from food consumption data. Genotyping was conducted for the Ile105Val variant of GSTP1. Multivariable models were used to assess associations between size at birth and dietary B(a)P, evaluating potential interactions with candidate nutrients and GSTP1 variants. Results: There were significant interactions between elevated intakes of vitamin C (above the mean of 189.41 mg/day) and dietary B(a)P during the first trimester of pregnancy in models for birth weight and length (P < 0.05), but no interactions were found with other nutrients. B(a)P intakes were associated with significant reductions in birth weight and length (coefficient ± SE for a 1-SD increase in B(a)P: − 101.63 ± 34.62 g and − 0.38 ± 0.16 cm, respectively) among women with low, but not high, vitamin C intakes. Elevated dietary B(a)P was also associated with increased risk of SGA births among women with low dietary vitamin C. Among these women, associations were strongest in those carrying the GSTP1 Val allele, associated with lower contaminant detoxification activity. Conclusion: Results suggest that dietary B(a)P exposure may impair fetal growth, particularly in genetically susceptible populations, and that increasing maternal intakes of vitamin C may help to reduce any adverse effects.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Environment International. 2012;45:1-8
dc.rights © Elsevier http://dx.doi.org/10.1016/j.envint.2012.04.002
dc.title Dietary benzo(a)pyrene and fetal growth: effect modification by vitamin C intake and glutathione S-transferase P1 polymorphism
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2012.04.002
dc.subject.keyword Benzo(a)pyrene
dc.subject.keyword Diet
dc.subject.keyword Pregnancy
dc.subject.keyword Vitamin C
dc.subject.keyword Glutathione S-transferase P1
dc.subject.keyword Fetal growth
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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