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Ancient gene flow from early modern humans into Eastern Neanderthals

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dc.contributor.author Kuhlwilm, Martin
dc.contributor.author Prado Martínez, Javier, 1987-
dc.contributor.author Lalueza Fox, Carles, 1965-
dc.contributor.author Marquès i Bonet, Tomàs, 1975-
dc.contributor.author Castellano Hereza, Sergi
dc.date.accessioned 2019-01-16T08:22:40Z
dc.date.available 2019-01-16T08:22:40Z
dc.date.issued 2016
dc.identifier.citation Kuhlwilm M, Gronau I, Hubisz MJ, de Filippo C, Prado-Martinez J, Kircher M et al. Ancient gene flow from early modern humans into Eastern Neanderthals. Nature. 2016 Feb 25; 530(7591): 429-33. DOI: 10.1038/nature16544
dc.identifier.issn 0028-0836
dc.identifier.uri http://hdl.handle.net/10230/36285
dc.description.abstract It has been shown that Neanderthals contributed genetically to modern humans outside Africa 47,000-65,000 years ago. Here we analyse the genomes of a Neanderthal and a Denisovan from the Altai Mountains in Siberia together with the sequences of chromosome 21 of two Neanderthals from Spain and Croatia. We find that a population that diverged early from other modern humans in Africa contributed genetically to the ancestors of Neanderthals from the Altai Mountains roughly 100,000 years ago. By contrast, we do not detect such a genetic contribution in the Denisovan or the two European Neanderthals. We conclude that in addition to later interbreeding events, the ancestors of Neanderthals from the Altai Mountains and early modern humans met and interbred, possibly in the Near East, many thousands of years earlier than previously thought.
dc.description.sponsorship M.J.H. was supported by the National Science Foundation Graduate Research Fellowship under grant DGE-1144153. T.M-B. was supported by ICREA, EMBO YIP 2013 and Fundació Barcelona Zoo. The Max Planck Society, the Krekeler Foundation, MINECO (grants BFU2014-55090-P FEDER, BFU2015-7116-ERC and BFU2015-6215-ERC to T.M-B. and BFU2012-34157 FEDER to C.L.-F.) and the US National Institutes of Health (grant GM102192 to A.S. and U01 MH106874 to T.M-B.) provided financial support
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Research
dc.rights © Springer Nature Publishing AG. Kuhlwilm M, Gronau I, Hubisz MJ, de Filippo C, Prado-Martinez J, Kircher M et al. Ancient gene flow from early modern humans into Eastern Neanderthals. Nature. 2016 Feb 25; 530(7591): 429-33. http://dx.doi.org/10.1038/nature16544
dc.subject.other Genètica
dc.subject.other Neandertals -- Genètica
dc.title Ancient gene flow from early modern humans into Eastern Neanderthals
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/ 10.1038/nature16544
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2014-55090-P
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-34157
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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