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Impact of recurrent acute kidney injury on patient outcomes

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dc.contributor.author Rodriguez García, Eva
dc.contributor.author Arias Cabrales, Carlos Enrique
dc.contributor.author Bermejo García, Sheila
dc.contributor.author Sierra Ochoa, Adriana
dc.contributor.author Burballa Tàrrega, Carla, 1988-
dc.contributor.author Soler, María José
dc.contributor.author Barrios Barrera, Clara
dc.date.accessioned 2018-12-03T09:15:08Z
dc.date.available 2018-12-03T09:15:08Z
dc.date.issued 2018
dc.identifier.citation Rodríguez E, Arias-Cabrales C, Bermejo S, Sierra A, Burballa C, Soler MJ. Et al. Impact of recurrent acute kidney injury on patient outcomes. Kidney Blood Press Res. 2018;43(1):34-44. DOI: 10.1159/000486744
dc.identifier.issn 1420-4096
dc.identifier.uri http://hdl.handle.net/10230/35936
dc.description.abstract BACKGROUND/AIMS: Recurrent acute kidney injury (AKI) is common among patients after a first hospitalized AKI. However, little is known about the prognosis of recurrent AKI episodes in chronic kidney disease (CKD) development, cardiovascular events and mortality. METHODS: A retrospective study included patients admitted to our Hospital from 2000 to 2010. AKI was defined according to the Acute Dialysis Quality Initiative criteria. In the follow-up period after the first AKI episode, clinical, laboratory data and the number of repeated AKI episodes, etiology and severity were recorded. RESULTS: Among the 359 AKI survivor patients included, 250 new AKI episodes were observed in 122 patients (34%). Variables independently associated to new episodes were: type 2 DM [OR 1.2, 95%CI 1.2-3.8, p=0.001], ischemic heart disease [OR 1.9; 95%CI 1.1-3.6, p=0.012], and SCr at the first AKI event>2,6 mg/dl [OR 1.2; 95%CI 1.03-1.42, p=0.02]. Development of CKD during four years follow-up was more frequent in patients with recurrent AKI, HR [2.2 (95% CI: 1.09-4.3, p=0.003)] and 44% of recurrent AKI patients who developed CKD occurred during the first 6 months after the initial event. Cardiovascular events were more frequent among patients with recurrent AKI patients than in those with one AKI episode (47.2% vs 24%, p=0.001). Mortality at 4 years was higher in the patient subgroup with several episodes of AKI as compared with those with a single episode [HR: 4.5 (95% CI 2.7-7.5) p<0.001]. CONCLUSION: Episodes of recurrent AKI have a high potential to be associated with relevant complications such as cardiovascular events, mortality and CKD development.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Karger (S. Karger AG)
dc.relation.ispartof Kidney and Blood Pressure Research. 2018;43(1):34-44
dc.rights This article is licensed under the https://creativecommons.org/licenses/by-nc/4.0/ (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission
dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0/
dc.subject.other Ronyons -- Malalties
dc.title Impact of recurrent acute kidney injury on patient outcomes
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1159/000486744
dc.subject.keyword Chronic kidney disease
dc.subject.keyword Mortality
dc.subject.keyword Outcomes;
dc.subject.keyword Recurrent AKI
dc.subject.keyword Renal prognosis
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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