dc.contributor.author |
Martínez-Casanova, Javier |
dc.contributor.author |
Carballo Martínez, Núria |
dc.contributor.author |
Luque Pardos, Sònia |
dc.contributor.author |
Sorli Redó, M. Luisa |
dc.contributor.author |
Grau Cerrato, Santiago |
dc.date.accessioned |
2018-11-20T10:04:34Z |
dc.date.available |
2018-11-20T10:04:34Z |
dc.date.issued |
2018 |
dc.identifier.citation |
Martínez-Casanova J, Carballo N, Luque S, Sorli L, Grau S. Posaconazole achieves prompt recovery of voriconazole-induced liver injury in a case of invasive aspergillosis. Infect Drug Resist. 2018 Mar 5;11:317-321. DOI: 10.2147/IDR.S154457 |
dc.identifier.issn |
1178-6973 |
dc.identifier.uri |
http://hdl.handle.net/10230/35796 |
dc.description.abstract |
Azole antifungals have frequently been linked to the presence of hepatotoxicity, but there is scarce information on cross-toxicity between these drugs or on the possibility of using some of them when this type of toxicity occurs. We report the case of a 64-year-old man with invasive aspergillosis (IA) leading to spondylodiscitis with neurological involvement. Early management included intravenous (iv) voriconazole, which had to be interrupted after 1 week due to liver damage. Therapeutic drug monitoring (TDM) of voriconazole showed that the plasma concentration was within the therapeutic range. However, it was replaced by a combination therapy of oral posaconazole plus iv caspofungin. Posaconazole allowed normalization of liver enzymes. After finishing posaconazole monotherapy on an outpatient basis, the patient made a full recovery. This case report provides further evidence that oral posaconazole is safe and effective as rescue therapy after the appearance of voriconazole-induced liver toxicity. |
dc.format.mimetype |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Dove Medical Press |
dc.relation.ispartof |
Infection and Drug Resistance. 2018 Mar 5;11:317-21 |
dc.rights |
Copyright © 2018 Martínez-Casanova et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php sand incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
dc.rights.uri |
https://creativecommons.org/licenses/by-nc/3.0/ |
dc.subject.other |
Fetge -- Medicaments -- Toxicologia |
dc.title |
Posaconazole achieves prompt recovery of voriconazole-induced liver injury in a case of invasive aspergillosis |
dc.type |
info:eu-repo/semantics/article |
dc.identifier.doi |
http://dx.doi.org/10.2147/IDR.S154457 |
dc.subject.keyword |
Antifungal agents |
dc.subject.keyword |
Case report |
dc.subject.keyword |
Hepatotoxicity |
dc.subject.keyword |
Therapeutic drug monitoring |
dc.rights.accessRights |
info:eu-repo/semantics/openAccess |
dc.type.version |
info:eu-repo/semantics/publishedVersion |