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Posaconazole achieves prompt recovery of voriconazole-induced liver injury in a case of invasive aspergillosis

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dc.contributor.author Martínez-Casanova, Javier
dc.contributor.author Carballo Martínez, Núria
dc.contributor.author Luque Pardos, Sònia
dc.contributor.author Sorli Redó, M. Luisa
dc.contributor.author Grau Cerrato, Santiago
dc.date.accessioned 2018-11-20T10:04:34Z
dc.date.available 2018-11-20T10:04:34Z
dc.date.issued 2018
dc.identifier.citation Martínez-Casanova J, Carballo N, Luque S, Sorli L, Grau S. Posaconazole achieves prompt recovery of voriconazole-induced liver injury in a case of invasive aspergillosis. Infect Drug Resist. 2018 Mar 5;11:317-321. DOI: 10.2147/IDR.S154457
dc.identifier.issn 1178-6973
dc.identifier.uri http://hdl.handle.net/10230/35796
dc.description.abstract Azole antifungals have frequently been linked to the presence of hepatotoxicity, but there is scarce information on cross-toxicity between these drugs or on the possibility of using some of them when this type of toxicity occurs. We report the case of a 64-year-old man with invasive aspergillosis (IA) leading to spondylodiscitis with neurological involvement. Early management included intravenous (iv) voriconazole, which had to be interrupted after 1 week due to liver damage. Therapeutic drug monitoring (TDM) of voriconazole showed that the plasma concentration was within the therapeutic range. However, it was replaced by a combination therapy of oral posaconazole plus iv caspofungin. Posaconazole allowed normalization of liver enzymes. After finishing posaconazole monotherapy on an outpatient basis, the patient made a full recovery. This case report provides further evidence that oral posaconazole is safe and effective as rescue therapy after the appearance of voriconazole-induced liver toxicity.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Dove Medical Press
dc.relation.ispartof Infection and Drug Resistance. 2018 Mar 5;11:317-21
dc.rights Copyright © 2018 Martínez-Casanova et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php sand incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
dc.rights.uri https://creativecommons.org/licenses/by-nc/3.0/
dc.subject.other Fetge -- Medicaments -- Toxicologia
dc.title Posaconazole achieves prompt recovery of voriconazole-induced liver injury in a case of invasive aspergillosis
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.2147/IDR.S154457
dc.subject.keyword Antifungal agents
dc.subject.keyword Case report
dc.subject.keyword Hepatotoxicity
dc.subject.keyword Therapeutic drug monitoring
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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