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Dietary Polyphenols, Mediterranean Diet, Prediabetes, and Type 2 Diabetes: A Narrative Review of the Evidence

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dc.contributor.author Guasch Ferré, Marta
dc.contributor.author Merino, Jorsi
dc.contributor.author Sun, Qi
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Salas-Salvadó, Jordi
dc.date.accessioned 2018-07-11T07:58:11Z
dc.date.available 2018-07-11T07:58:11Z
dc.date.issued 2017
dc.identifier.citation Guasch-Ferré M, Merino J, Sun Q, Fitó M, Salas-Salvadó J. Dietary Polyphenols, Mediterranean Diet, Prediabetes, and Type 2 Diabetes: A Narrative Review of the Evidence. Send to Oxid Med Cell Longev. 2017;2017:6723931. DOI: 10.1155/2017/6723931
dc.identifier.issn 1942-0994
dc.identifier.uri http://hdl.handle.net/10230/35122
dc.description.abstract Dietary polyphenols come mainly from plant-based foods including fruits, vegetables, whole grains, coffee, tea, and nuts. Polyphenols may influence glycemia and type 2 diabetes (T2D) through different mechanisms, such as promoting the uptake of glucose in tissues, and therefore improving insulin sensitivity. This review aims to summarize the evidence from clinical trials and observational prospective studies linking dietary polyphenols to prediabetes and T2D, with a focus on polyphenol-rich foods characteristic of the Mediterranean diet. We aimed to describe the metabolic biomarkers related to polyphenol intake and genotype-polyphenol interactions modulating the effects on T2D. Intakes of polyphenols, especially flavan-3-ols, and their food sources have demonstrated beneficial effects on insulin resistance and other cardiometabolic risk factors. Several prospective studies have shown inverse associations between polyphenol intake and T2D. The Mediterranean diet and its key components, olive oil, nuts, and red wine, have been inversely associated with insulin resistance and T2D. To some extent, these associations may be attributed to the high amount of polyphenols and bioactive compounds in typical foods conforming this traditional dietary pattern. Few studies have suggested that genetic predisposition can modulate the relationship between polyphenols and T2D risk. In conclusion, the intake of polyphenols may be beneficial for both insulin resistance and T2D risk.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Hindawi
dc.relation.ispartof Oxidative Medicine and Cellular Longevity. 2017;2017:6723931
dc.rights Copyright © 2017 Marta Guasch-Ferré et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject.other Polifenols
dc.subject.other Dieta mediterrània
dc.title Dietary Polyphenols, Mediterranean Diet, Prediabetes, and Type 2 Diabetes: A Narrative Review of the Evidence
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1155/2017/6723931
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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