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Bloqueo del sistema renina-angiotensina-aldosterona en pacientes con enfermedad renal diabética avanzada

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dc.contributor.author Bermejo García, Sheila
dc.contributor.author García, Carles Oriol
dc.contributor.author Rodríguez García, Eva
dc.contributor.author Barrios Barrera, Clara
dc.contributor.author Otero, Sol
dc.contributor.author Mojal, Sergio
dc.contributor.author Pascual Santos, Julio
dc.contributor.author Soler, María José
dc.date.accessioned 2018-07-04T07:46:29Z
dc.date.available 2018-07-04T07:46:29Z
dc.date.issued 2018
dc.identifier.citation Bermejo S, García CO, Rodríguez E, Barrios C, Otero S, Mojal S. et al. Bloqueo del sistema renina-angiotensina-aldosterona en pacientes con enfermedad renal diabética avanzada. Nefrologia. 2018 Mar-Apr;38(2):197-206. DOI: 10.1016/j.nefro.2017.07.003
dc.identifier.issn 0211-6995
dc.identifier.uri http://hdl.handle.net/10230/35024
dc.description.abstract BACKGROUND AND OBJECTIVES: Diabetic kidney disease is the leading cause of end-stage chronic kidney disease. The renin-angiotensin-aldosterone system (RAAS) blockade has been shown to slow the progression of diabetic kidney disease. Our objectives were: to study the percentage of patients with diabetic kidney disease treated with RAAS blockade, to determine its renal function, safety profile and assess whether its administration is associated with increased progression of CKD after 3 years of follow-up. MATERIALS AND METHODS: Retrospective study. 197 diabetic kidney disease patients were included and divided into three groups according to the treatment: patients who had never received RAAS blockade (non-RAAS blockade), patients who at some point had received RAAS blockade (inconstant-RAAS blockade) and patients who received RAAS blockade (constant-RAAS blockade). Clinical characteristics and analytical variables such as renal function, electrolytes, glycosylated haemoglobin and glomerular filtration rate according to chronic kidney disease -EPI and MDRD formulas were assessed. We also studied their clinical course (baseline, 1 and 3 years follow-up) in terms of treatment group, survival, risk factors and renal prognosis. RESULTS: Non-RAAS blockade patients had worse renal function and older age (p<0.05) at baseline compared to RAAS blockade patients. Patients who received RAAS blockade were not found to have greater toxicity or chronic kidney disease progression and no differences in renal prognosis were identified. Mortality was higher in non-RAAS blockade patients, older patients and patients with worse renal function (p<0.05). In the multivariate analysis, older age and worse renal function were risk factors for mortality. CONCLUSIONS: Treatment with RAAS blockade is more common in diabetic kidney disease patients with eGFR≥30ml/min/1.73m2. In our study, there were no differences in the evolution of renal function between the three groups. Older age and worse renal function were associated with higher mortality in patients who did not receive RAAS blockade.
dc.format.mimetype application/pdf
dc.language.iso spa
dc.publisher Elsevier
dc.relation.ispartof Nefrologia. 2018 Mar-Apr;38(2):197-206
dc.rights ©2017 Sociedad Espanola de Nefrología. Publicado por Elsevier España, S.L.U. Este es un artículo Open Access bajo la licencia CCBY-NC-ND (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0
dc.subject.other Ronyons -- Malalties
dc.subject.other Diabetis
dc.title Bloqueo del sistema renina-angiotensina-aldosterona en pacientes con enfermedad renal diabética avanzada
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.nefro.2017.07.003
dc.subject.keyword Bloqueo del sistema renina-angiotensina-aldosterona
dc.subject.keyword Chronic kidney disease
dc.subject.keyword Diabetes mellitus
dc.subject.keyword Diabetic kidney disease
dc.subject.keyword Enfermedad renal crónica
dc.subject.keyword Enfermedad renal diabética
dc.subject.keyword Renin-angiotensin-aldosterone system blockade
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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