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Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPD

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dc.contributor.author Rodríguez Chiaradia, Diego Agustín
dc.contributor.author Kortianou, Eleni A.
dc.contributor.author Alison, Jennifer A.
dc.contributor.author Casas, Alejandro
dc.contributor.author Giavedoni, Santiago
dc.contributor.author Barberan-Garcia, Anael
dc.contributor.author Arbillaga Etxarri, Ane, 1986-
dc.contributor.author Vilaró, Jordi
dc.contributor.author Gimeno Santos, Elena, 1980-
dc.contributor.author Vogiatzis, Ioannis
dc.contributor.author Rabinovich, Roberto A.
dc.contributor.author Roca Torrent, Josep
dc.date.accessioned 2018-06-26T07:42:10Z
dc.date.available 2018-06-26T07:42:10Z
dc.date.issued 2017
dc.identifier.citation Rodríguez DA, Kortianou EA, Alison JA, Casas A, Giavedoni S, Barberan-Garcia A et al. Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPD. Lung. 2017 Aug;195(4):463-7. DOI: 10.1007/s00408-017-0027-0
dc.identifier.issn 0341-2040
dc.identifier.uri http://hdl.handle.net/10230/34966
dc.description.abstract INTRODUCTION: Abnormalities of autonomic function have been reported in patients with chronic obstructive pulmonary disease (COPD). Our objectives were to identify determinants of abnormal heart rate recovery at 1 min (HRR1) following completion of the 6-min walk test (6MWT) in COPD and to establish whether abnormal HRR1 predicts acute exacerbations (AECOPD). METHODS: Hundred one COPD patients (FEV1 (SD) 53 (19) % predicted) were prospectively recruited in a multi-center study. HRR1 after the 6MWT was evaluated as the difference between heart rate at the end of the test and 1 min into the recovery (HRR1). Linear and logistic regression was used to identify predictors of HRR1 and AECOPD, respectively. The best HRR1 cut-off point to predict AECOPD was selected using the receiver operating characteristics (ROC) curves. The follow-up period was 12 months. RESULTS: Distance covered during the 6MWT (m) and DLco (% predicted) were independently associated with HRR1 (r 2 = 0.51, p = 0.001). Among several potential covariates, HRR1 emerged as the most significant predictor of AECOPD (Odds ratio [OR], 0.91 per beat of recovery; 95% confidence interval [CI], 0.85-0.97; p = 0.02). The ROC analysis indicated that subjects with HRR1 less than 14 beats (AUC, 0.71 [CI] 0.60-0.80; p = 0.0001) were more likely to suffer an exacerbation during the follow-up period (for HRR1, p = 0.004 [log-rank test]). CONCLUSIONS: HRR1 after the 6MWT is an independent predictor factor for AECOPD. Further studies are warranted to examine the physiological mechanisms associating a delayed HRR and acute exacerbations in COPD patients.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Lung. 2017 Aug;195(4):463-7
dc.rights © Springer The final publication is available at Springer via http://dx.doi.org/10.1007/s00408-017-0027-0
dc.subject.other Marcadors bioquímics
dc.subject.other Pulmons--Malalties obstructives
dc.subject.other Exercici
dc.title Heart Rate Recovery After 6-min Walking Test Predicts Acute Exacerbation in COPD
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1007/s00408-017-0027-0
dc.subject.keyword Biomarker
dc.subject.keyword COPD
dc.subject.keyword Exercise
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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