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Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study

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dc.contributor.author Yu, Edward
dc.contributor.author Ruiz-Canela, Miguel
dc.contributor.author Hu, Frank B.
dc.contributor.author Clish, Clary B.
dc.contributor.author Corella, Dolores
dc.contributor.author Salas-Salvadó, Jordi
dc.contributor.author Hruby, Adela
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Liang, Liming
dc.contributor.author Toledo, Estefania
dc.contributor.author Ros, Emilio
dc.contributor.author Estruch, Ramón
dc.contributor.author Gómez-Gracia, Enrique
dc.contributor.author Lapetra, José
dc.contributor.author Arós, Fernando
dc.contributor.author Romaguera Bosch, Dora
dc.contributor.author Serra-Majem, Luis
dc.contributor.author Guasch Ferré, Marta
dc.contributor.author Wang, Dong D.
dc.contributor.author Martínez-González, Miguel A.
dc.date.accessioned 2018-06-12T07:38:24Z
dc.date.available 2018-06-12T07:38:24Z
dc.date.issued 2017
dc.identifier.citation Yu E, Ruiz-Canela M, Hu FB, Clish CB, Corella D, Salas-Salvadó J. et al. Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study. J Clin Endocrinol Metab. 2017 Jun 1;102(6):1879-1888. DOI: 10.1210/jc.2016-3569
dc.identifier.issn 0021-972X
dc.identifier.uri http://hdl.handle.net/10230/34875
dc.description.abstract CONTEXT: Arginine, its methylated metabolites, and other metabolites related to the urea cycle have been independently associated with cardiovascular risk, but the potential causal meaning of these associations (positive for some metabolites and negative for others) remains elusive due to a lack of studies measuring metabolite changes over time. OBJECTIVE: To examine the association between baseline and 1-year concentrations of urea cycle metabolites and cardiovascular disease (CVD) in a case-cohort setting. DESIGN: A case-cohort study was nested within the Prevención con Dieta Mediterránea trial. We used liquid chromatography-tandem mass spectrometry to assess metabolite levels at baseline and after 1-year follow-up. The primary CVD outcome was a composite of myocardial infarction, stroke and cardiovascular death. We used weighted Cox regression models (Barlow weights) to estimate multivariable-adjusted hazard ratios (HRs) and their 95% confidence intervals (CIs). SETTING: Multicenter randomized trial in Spain. PARTICIPANTS: Participants were 984 participants accruing 231 events over 4.7 years' median follow-up. MAIN OUTCOME MEASURE: Incident CVD. RESULTS: Baseline arginine/asymmetric dimethylarginine ratio [HR per standard deviation (SD) = 0.80; 95% CI, 0.67 to 0.96] and global arginine availability [arginine / (ornithine + citrulline)] (HR per SD = 0.83; 95% CI, 0.69 to 1.00) were significantly associated with lower risk of CVD. We observed no significant association for 1-year changes in these ratios or any effect modification by the Mediterranean diet (MD) intervention. CONCLUSIONS: A higher baseline arginine/asymmetric dimethylarginine ratio was associated with lower CVD incidence in a high cardiovascular risk population. The intervention with the MD did not change 1-year levels of these metabolites.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.rights © Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in J Clin Endocrinol Metab. following peer review. The definitive publisher-authenticated version Yu E, Ruiz-Canela M, Hu FB, Clish CB, Corella D, Salas-Salvadó J. et al. Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study. J Clin Endocrinol Metab. 2017 Jun 1;102(6):1879-1888. is available online at: https://academic.oup.com/jcem/article/102/6/1879/3060512
dc.subject.other Sistema cardiovascular -- Malalties
dc.subject.other Dieta -- Mediterrània, Regió de la
dc.title Plasma Arginine/Asymmetric Dimethylarginine Ratio and Incidence of Cardiovascular Events: A Case-Cohort Study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1210/jc.2016-3569
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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