Welcome to the UPF Digital Repository

Percutaneous coronary intervention reduces mortality in myocardial infarction patients with comorbidities: Implications for elderly patients with diabetes or kidney disease

Show simple item record

dc.contributor.author Dégano, Irene R.
dc.contributor.author Subirana Cachinero, Isaac
dc.contributor.author Fusco, Danilo
dc.contributor.author Tavazzi, Luigi
dc.contributor.author Kirchberger, Inge
dc.contributor.author Farmakis, Dimitrios
dc.contributor.author Ferrières, Jean
dc.contributor.author Azevedo, Ana
dc.contributor.author Torre, Marina
dc.contributor.author Garel, Pascal
dc.contributor.author Brosa Riestra, Max
dc.contributor.author Davoli, Marina
dc.contributor.author Meisinger, Christa
dc.contributor.author Bongard, Vanina
dc.contributor.author Araújo, Carla
dc.contributor.author Lekakis, John
dc.contributor.author Francés, Albert
dc.contributor.author Castell, Conxa
dc.contributor.author Elosua Llanos, Roberto
dc.contributor.author Marrugat de la Iglesia, Jaume
dc.contributor.author EUROTRACS investigators
dc.date.accessioned 2018-06-05T07:18:42Z
dc.date.available 2018-06-05T07:18:42Z
dc.date.issued 2017
dc.identifier.citation Dégano IR, Subirana I, Fusco D, Tavazzi L, Kirchberger I, Farmakis D. et al. Percutaneous coronary intervention reduces mortality in myocardial infarction patients with comorbidities: Implications for elderly patients with diabetes or kidney disease. Int J Cardiol. 2017 Dec 15;249:83-89. DOI: 10.1016/j.ijcard.2017.07.054
dc.identifier.issn 0167-5273
dc.identifier.uri http://hdl.handle.net/10230/34821
dc.description.abstract BACKGROUND: Percutaneous coronary intervention (PCI) reduces mortality in most myocardial infarction (MI) patients but the effect on elderly patients with comorbidities is unclear. Our aim was to analyse the effect of PCI on in-hospital mortality of MI patients, by age, sex, ST elevation on presentation, diabetes mellitus (DM) and chronic kidney disease (CKD). METHODS: Cohort study of 79,791 MI patients admitted at European hospitals during 2000-2014. The effect of PCI on in-hospital mortality was analysed by age group (18-74, ≥75years), sex, presence of ST elevation, DM and CKD, using propensity score matching. The number needed to treat (NNT) to prevent a fatal event was calculated. Sensitivity analyses were conducted. RESULTS: PCI was associated with lower in-hospital mortality in ST and non-ST elevation MI (STEMI and NSTEMI) patients. The effect was stronger in men [Odds ratio (95% confidence interval) 0.30 (0.25-0.35)] than in women [0.46 (0.39-0.54)] aged ≥75years, and in NSTEMI [0.22 (0.17-0.28)] than in STEMI patients [0.40 (0.31-0.5)] aged <75years. PCI reduced in-hospital mortality risk in patients with and without DM or CKD (54-72% and 52-73% reduction in DM and CKD patients, respectively). NNT was lower in patients with than without CKD [≥75years: STEMI=6(5-8) vs 9(8-10); NSTEMI=10(8-13) vs 16(14-20)]. Sensitivity analyses such as exclusion of hospital stays <2days yielded similar results. CONCLUSIONS: PCI decreased in-hospital mortality in MI patients regardless of age, sex, and presence of ST elevation, DM and CKD. This supports the recommendation for PCI in elderly patients with DM or CKD.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof International Journal of Cardiology. 2017 Dec 15;249:83-9
dc.rights © 2017 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.other Ronyons -- Malalties
dc.subject.other Diabetis -- Complicacions
dc.subject.other Infart de miocardi
dc.subject.other Persones grans
dc.title Percutaneous coronary intervention reduces mortality in myocardial infarction patients with comorbidities: Implications for elderly patients with diabetes or kidney disease
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.ijcard.2017.07.054
dc.subject.keyword Chronic kidney disease
dc.subject.keyword Diabetes mellitus
dc.subject.keyword Elderly
dc.subject.keyword Myocardial infarction
dc.subject.keyword Percutaneous coronary intervention
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Search DSpace


Advanced Search

Browse

My Account

Statistics

In collaboration with Compliant to Partaking