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Mammalian HP1 isoforms have specific roles in heterochromatin structure and organization

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dc.contributor.author Bosch Presegué, Laia
dc.contributor.author Raurell Vila, Helena
dc.contributor.author Thackray, Joshua K.
dc.contributor.author González, Jessica V.
dc.contributor.author Casal, Carmen
dc.contributor.author Kane-Goldsmith, Noriko
dc.contributor.author Vizoso, Miguel
dc.contributor.author Brown, Jeremy P.
dc.contributor.author Gómez, Antonio
dc.contributor.author Ausió, Juan
dc.contributor.author Zimmermann, Timo
dc.contributor.author Esteller, Manel
dc.contributor.author Schotta, Gunnar
dc.contributor.author Singh, Prim B.
dc.contributor.author Serrano, Lourdes
dc.contributor.author Vaquero, Alejandro
dc.date.accessioned 2018-05-24T07:54:29Z
dc.date.available 2018-05-24T07:54:29Z
dc.date.issued 2017
dc.identifier.citation Bosch-Presegué L, Raurell-Vila H, Thackray JK, González J, Casal C, Kane-Goldsmith N et al. Mammalian HP1 Isoforms Have Specific Roles in Heterochromatin Structure and Organization. Cell Reports 2017 Nov; 21(8): 2048-2057. DOI: 10.1016/j.celrep.2017.10.092
dc.identifier.issn 2211-1247
dc.identifier.uri http://hdl.handle.net/10230/34717
dc.description.abstract HP1 is a structural component of heterochromatin. Mammalian HP1 isoforms HP1α, HP1β, and HP1γ play different roles in genome stability, but their precise role in heterochromatin structure is unclear. Analysis of Hp1α-/-, Hp1β-/-, and Hp1γ-/- MEFs show that HP1 proteins have both redundant and unique functions within pericentric heterochromatin (PCH) and also act globally throughout the genome. HP1α confines H4K20me3 and H3K27me3 to regions within PCH, while its absence results in a global hyper-compaction of chromatin associated with a specific pattern of mitotic defects. In contrast, HP1β is functionally associated with Suv4-20h2 and H4K20me3, and its loss induces global chromatin decompaction and an abnormal enrichment of CTCF in PCH and other genomic regions. Our work provides insight into the roles of HP1 proteins in heterochromatin structure and genome stability.
dc.description.sponsorship This work was supported by the Spanish Ministry of Economy and Competitiveness (MINECO) (SAF2011-25860 and SAF2014-55964R to A.V.) and cofunded by FEDER funds/European Regional Development Fund (ERDF)-a way to build Europe, the Catalan Government Agency AGAUR (2009SGR-914 and 2014SGR-400 to A.V.), HGINJ (to L.S.), Deutsche Forschungsgemeinschaft (SFB1064 to G.S.), and the Canadian Institutes of Health Research (CIHR) (MOP-97878 to J.A.).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Cell Reports 2017 Nov; 21(8): 2048-2057
dc.rights © 2017 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Mammalian HP1 isoforms have specific roles in heterochromatin structure and organization
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.celrep.2017.10.092
dc.subject.keyword H4K20me3
dc.subject.keyword HP1α
dc.subject.keyword HP1β
dc.subject.keyword HP1γ
dc.subject.keyword Suv420h2
dc.subject.keyword Genome organization
dc.subject.keyword Genome stability
dc.subject.keyword Heterochromatin
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2011-25860
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/SAF2014-55964-R
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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