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Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial

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dc.contributor.author Cantero, Irene
dc.contributor.author Abete, Itziar
dc.contributor.author Babio, Nancy
dc.contributor.author Arós, Fernando
dc.contributor.author Corella, Dolores
dc.contributor.author Estruch, Ramón
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Hebert, James R.
dc.contributor.author Martínez-González, Miguel A.
dc.contributor.author Pinto, Xavier
dc.contributor.author Puy Portillo, Maria
dc.contributor.author Ruiz-Canela, Miguel
dc.contributor.author Shivappa, Nitin
dc.contributor.author Warnberg, Julia
dc.contributor.author Gomez-Gracia, Enrique
dc.contributor.author Tur, J. Antoni
dc.contributor.author Salas Salvadó, Jordi
dc.contributor.author Zulet, M. Angeles
dc.contributor.author Martínez, J. Alfredo
dc.date.accessioned 2018-05-09T07:36:09Z
dc.date.issued 2018
dc.identifier.citation Cantero I, Abete I, Babio N, Arós F, Corella D, Estruch R. et al. Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial. Clin Nutr. 2018 Oct;37(5):1736-1743. DOI: 10.1016/j.clnu.2017.06.027
dc.identifier.issn 0261-5614
dc.identifier.uri http://hdl.handle.net/10230/34584
dc.description.abstract BACKGROUND & AIMS: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. METHODS: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvención con DIeta MEDiterránea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-α and C-reactive protein). Furthermore, a validated 137-item food-frequency-questionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated. RESULTS: A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern. CONCLUSIONS: This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative anti-inflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Clinical Nutrition. 2018 Oct;37(5):1736-43
dc.rights © Elsevier http://dx.doi.org/[núm.DOI]
dc.subject.other Dieta
dc.subject.other Inflamació
dc.subject.other Obesitat
dc.subject.other Fetge -- Malalties
dc.title Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.clnu.2017.06.027
dc.subject.keyword Diet
dc.subject.keyword Inflammation
dc.subject.keyword Liver
dc.subject.keyword NAFLD
dc.subject.keyword Obesity
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion
dc.embargo.liftdate 2018-07-31


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