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Chromium Exposure and Risk of Cardiovascular Disease in High Cardiovascular Risk Subjects - Nested Case-Control Study in the Prevention With Mediterranean Diet (PREDIMED) Study

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dc.contributor.author Gutiérrez-Bedmar, Mario
dc.contributor.author Martínez-González, Miguel A.
dc.contributor.author Muñoz-Bravo, Carlos
dc.contributor.author Ruiz-Canela, Miguel
dc.contributor.author Mariscal, Alberto
dc.contributor.author Salas Salvadó, Jordi
dc.contributor.author Estruch, Ramón
dc.contributor.author Corella, Dolores
dc.contributor.author Arós, Fernando
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Lapetra, José
dc.contributor.author Serra-Majem, Luis
dc.contributor.author Ros, Emilio
dc.contributor.author Alonso-Gómez, Ángel
dc.contributor.author Portolés, Olga
dc.contributor.author Fiol, Miquel
dc.contributor.author Bulló, Mònica
dc.contributor.author Castañer, Olga
dc.contributor.author Pinto, Xavier
dc.contributor.author Gómez-Gracia, Enrique
dc.date.accessioned 2018-05-04T07:24:09Z
dc.date.available 2018-05-04T07:24:09Z
dc.date.issued 2017
dc.identifier.citation Gutiérrez-Bedmar M, Martínez-González MÁ, Muñoz-Bravo C, Ruiz-Canela M, Mariscal A, Salas-Salvadó J. et al. Chromium Exposure and Risk of Cardiovascular Disease in High Cardiovascular Risk Subjects - Nested Case-Control Study in the Prevention With Mediterranean Diet (PREDIMED) Study. Circ J. 2017 Jul 25;81(8):1183-1190. DOI: 10.1253/circj.CJ-17-0032
dc.identifier.issn 1347-4820
dc.identifier.uri http://hdl.handle.net/10230/34551
dc.description.abstract BACKGROUND: Epidemiological data on chromium (Cr) exposure and the risk of cardiovascular disease (CVD) are still limited. Toenail Cr level (TCL) provides a time-integrated measure reflecting long-term Cr exposure. We measured TCL to assess the hypothesis that long-term Cr exposure was inversely associated with incident CVD in a population at high risk for CVD.Methods and Results:The associations between TCL and CVD were evaluated in a case-control study nested within the "PREvención con DIeta MEDiterránea" (PREDIMED) trial. We randomly selected 147 of the 288 patients diagnosed with CVD during follow-up and matched them on age and sex to 271 controls. Instrumental neutron activation analysis was used to assess TCL. In-person interviews, medical record reviews, and validated questionnaires were used to assess covariates. The fully adjusted OR for the highest vs. lowest quartile of toenail Cr was 0.54 (95% CI: 0.26-1.14; Ptrend=0.189) for the nested case-control study. On stratification for diabetes mellitus (DM), OR was 1.37 (95% CI: 0.54-3.46; Ptrend=0.364) for the DM group, and 0.25 (95% CI: 0.08-0.80; Ptrend=0.030) for the non-DM group (P for interaction=0.078). CONCLUSIONS: The present findings, although not statistically significant, are consistent with previously reported inverse associations between TCL and CVD. These results, especially for non-DM patients, increase the limited epidemiological knowledge about the possible protective role of Cr against CVD. (Trial registration: www.controlled-trials.com; ISRCTN35739639.).
dc.description.sponsorship This research was supported by the official funding agency for biomedical research of the Spanish Government, Instituto de Salud Carlos III (ISCIII), through grants provided to research networks specifically developed for the trial (RTIC G03/140 to R.E.; RTIC RD 06/0045 “PREDIMED” to M.A.M-G.), and JR14/00008 to O.C., and through Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), and by grants from Centro Nacional de Investigaciones Cardiovasculares (CNIC 06/2007), Fondo de Investigación Sanitaria-Fondo Europeo de Desarrollo Regional (Proyecto de Investigación (PI) 04-2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, P11/02505 and PI13/00462), Ministerio de Ciencia e Innovación (Recursos y teconologia agroalimentarias (AGL)-2009-13906-C02 and AGL2010-22319-C03 and AGL2013-49083C3-1-R), Fundación Mapfre 2010, Consejería de Salud de la Junta de Andalucía (PI0105/2007), Public Health Division of the Department of Health of the Autonomous Government of Catalonia, Generalitat Valenciana (Generalitat Valenciana Ayuda Complementatia GVACOMP) 06109, GVACOMP2010-181, GVACOMP2011-151), Conselleria de Sanitat y AP; Atención Primaria (CS) 2010-AP-111, and CS2011-AP-042), Regional Government of Navarra (P27/2011), and Centre Català de la Nutrició de l’Institut d’Estudis Catalans. Hojiblanca and Patrimonio Communal Olivarero donated extra-virgin olive oil; the California Walnut Commission donated walnuts; Borges donated almonds; La Morella Nuts donated hazelnuts.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher  The Japanese Circulation Society 
dc.relation.ispartof Circulation Journal 2017 Jul 25;81(8):1183-90
dc.rights © 2017 The Japanese Circulation Society
dc.subject.other Malalties cardiovasculars
dc.subject.other Diabetis
dc.subject.other Metalls -- Efectes fisiològics
dc.title Chromium Exposure and Risk of Cardiovascular Disease in High Cardiovascular Risk Subjects - Nested Case-Control Study in the Prevention With Mediterranean Diet (PREDIMED) Study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1253/circj.CJ-17-0032
dc.subject.keyword Cardiovascular disease
dc.subject.keyword Chromium
dc.subject.keyword Diabetes
dc.subject.keyword PREDIMED
dc.subject.keyword Toenail biomarker
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL-2009-13906-C02
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/AGL2010-22319-C03
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/AGL2013-49083C3-1-R
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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