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Acute pharmacological effects of 2C-B in humans: An observational study

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dc.contributor.author Papaseit Fontanet, Esther
dc.contributor.author Farré Albaladejo, Magí
dc.contributor.author Pérez Mañá, Clara
dc.contributor.author Torrens, Marta
dc.contributor.author Ventura, Mireia
dc.contributor.author Pujadas, Mitona
dc.contributor.author Torre Fornell, Rafael de la
dc.contributor.author González, Débora
dc.date.accessioned 2018-04-16T07:30:19Z
dc.date.available 2018-04-16T07:30:19Z
dc.date.issued 2018
dc.identifier.citation Papaseit E, Farré M, Pérez-Mañá C, Torrens M, Ventura M, Pujadas M et al. Acute Pharmacological Effects of 2C-B in Humans: An Observational Study. Front Pharmacol. 2018 Mar 13;9:206. DOI: 10.3389/fphar.2018.00206. eCollection 2018
dc.identifier.issn 1663-9812
dc.identifier.uri http://hdl.handle.net/10230/34357
dc.description.abstract 2,5-dimethoxy-4-bromophenethylamine (2C-B) is a psychedelic phenylethylamine derivative, structurally similar to mescaline. It is a serotonin 5-hydroxytryptamine-2A (5-HT2A), 5-hydroxytryptamine-2B (5-HT2B), and 5-hydroxytryptamine-2C (5-HT2C) receptor partial agonist used recreationally as a new psychoactive substance. It has been reported that 2C-B induces mild psychedelic effects, although its acute pharmacological effects and pharmacokinetics have not yet been fully studied in humans. An observational study was conducted to assess the acute subjective and physiological effects, as well as pharmacokinetics of 2C-B. Sixteen healthy, experienced drug users self-administered an oral dose of 2C-B (10, 15, or 20 mg). Vital signs (blood pressure and heart rate) were measured at baseline 1, 2, 3, 4, and 6 hours (h). Each participant completed subjective effects using three rating scales: the visual analog scale (VAS), the Addiction Research Centre Inventory (ARCI), and the Evaluation of the Subjective Effects of Substances with Abuse Potential (VESSPA-SSE) at baseline, 2-3 and 6 h after self-administration (maximum effects along 6 h), and the Hallucinogenic Rating Scale (maximum effects along 6 h). Oral fluid (saliva) was collected to assess 2C-B and cortisol concentrations during 24 h. Acute administration of 2C-B increased blood pressure and heart rate. Scores of scales related to euphoria increased (high, liking, and stimulated), and changes in perceptions (distances, colors, shapes, and lights) and different body feelings/surrounding were produced. Mild hallucinating effects were described in five subjects. Maximum concentrations of 2C-B and cortisol were reached at 1 and 3 h after self-administration, respectively. Oral 2C-B at recreational doses induces a constellation of psychedelic/psychostimulant-like effects similar to those associated with serotonin-acting drugs.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Frontiers
dc.relation.ispartof Frontiers in Pharmacology. 2018 Mar 13;9:206
dc.rights © 2018 Papaseit, Farré, Pérez-Mañá, Torrens, Ventura, Pujadas, de la Torre and González. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Acute pharmacological effects of 2C-B in humans: An observational study
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3389/fphar.2018.00206
dc.subject.keyword 2C-B (2,5-dimethoxy-4-bromophenethylamine)
dc.subject.keyword Psychedelic
dc.subject.keyword Phenylethylamines
dc.subject.keyword Psychostimulants
dc.subject.keyword Cortisol
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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