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Association between DNA methylation and coronary heart disease or other atherosclerotic events: A systematic review

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dc.contributor.author Fernández Sanlés, Alba, 1988-
dc.contributor.author Sayols, Sergi
dc.contributor.author Subirana Cachinero, Isaac
dc.contributor.author Dégano, Irene R.
dc.contributor.author Elosua Llanos, Roberto
dc.date.accessioned 2018-04-10T07:13:04Z
dc.date.issued 2017
dc.identifier.citation Fernández-Sanlés A, Sayols-Baixeras S, Subirana I, Degano IR, Elosua R. Association between DNA methylation and coronary heart disease or other atherosclerotic events: A systematic review. Atherosclerosis. 2017 Aug;263:325-33. DOI: 10.1016/j.atherosclerosis.2017.05.022
dc.identifier.issn 0021-9150
dc.identifier.uri http://hdl.handle.net/10230/34326
dc.description.abstract BACKGROUND AND AIMS: The aim of this study was to perform a systematic review of the association between DNA methylation and coronary heart disease (CHD) or related atherosclerotic traits. METHODS: A systematic review was designed. The condition of interest was DNA methylation, and the outcome was CHD or other atherosclerosis-related traits. Three DNA methylation approaches were considered: global methylation, candidate-gene, and epigenome-wide association studies (EWAS). A functional analysis was undertaken using the Ingenuity Pathway Analysis software. RESULTS: In total, 51 articles were included in the analysis: 12 global methylation, 34 candidate-gene and 11 EWAS, with six studies using more than one approach. The results of the global methylation studies were inconsistent. The candidate-gene results were consistent for some genes, suggesting that hypermethylation in ESRα, ABCG1 and FOXP3 and hypomethylation in IL-6 were associated with CHD. The EWAS identified 84 genes showing differential methylation associated with CHD in more than one study. The probability of these findings was <1.37·10-5. One third of these genes have been related to obesity in genome-wide association studies. The functional analysis identified several diseases and functions related to these set of genes: inflammatory, metabolic and cardiovascular disease. CONCLUSIONS: Global DNA methylation seems to be not associated with CHD. The evidence from candidate-gene studies was limited. The EWAS identified a set of 84 genes highlighting the relevance of obesity, inflammation, lipid and carbohydrate metabolism in CHD. This set of genes could be prioritized in future studies assessing the role of DNA methylation in CHD.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Atherosclerosis. 2017 Aug;263:325-33
dc.rights © Elsevier http://dx.doi.org/10.1016/j.atherosclerosis.2017.05.022
dc.subject.other Aterosclerosi
dc.subject.other Infart de miocardi
dc.subject.other Malalties coronàries
dc.subject.other ADN
dc.title Association between DNA methylation and coronary heart disease or other atherosclerotic events: A systematic review
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.atherosclerosis.2017.05.022
dc.subject.keyword Atherosclerosis
dc.subject.keyword Coronary heart disease
dc.subject.keyword DNA methylation
dc.subject.keyword Myocardial infarction
dc.subject.keyword Systematic review
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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