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Dementia prevalence and incidence in a federation of European Electronic Health Record databases: The European Medical Informatics Framework resource

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dc.contributor.author Perera, Gayan
dc.contributor.author Pedersen, Lars
dc.contributor.author Ansel, David
dc.contributor.author Alexander, Myriam
dc.contributor.author Arrighi, H. Michael
dc.contributor.author Avillach, Paul
dc.contributor.author Foskett, Nadia
dc.contributor.author Gini, Rosa
dc.contributor.author Gordon, Mark F.
dc.contributor.author Gungabissoona, Usha
dc.contributor.author Mayer, Miguel Ángel, 1960-
dc.contributor.author Novak, Gerald
dc.contributor.author Rijnbeek, Peter
dc.contributor.author Trifirò, Gianluca
dc.contributor.author van der Lei, Johan
dc.contributor.author Visser, Pieter J.
dc.contributor.author Stewart, Robert
dc.date.accessioned 2018-03-21T08:02:08Z
dc.date.available 2018-03-21T08:02:08Z
dc.date.issued 2018
dc.identifier.citation Perera G, Pedersen L, Ansel D, Alexander M, Arrighi HM, Avillach P et al. Dementia prevalence and incidence in a federation of European Electronic Health Record databases: The European Medical Informatics Framework resource. Alzheimers Dement. 2018 Feb;14(2):130-9. DOI: 10.1016/j.jalz.2017.06.2270
dc.identifier.issn 1552-5260
dc.identifier.uri http://hdl.handle.net/10230/34217
dc.description.abstract INTRODUCTION: The European Medical Information Framework consortium has assembled electronic health record (EHR) databases for dementia research. We calculated dementia prevalence and incidence in 25 million persons from 2004 to 2012. METHODS: Six EHR databases (three primary care and three secondary care) from five countries were interrogated. Dementia was ascertained by consensus harmonization of clinical/diagnostic codes. Annual period prevalences and incidences by age and gender were calculated and meta-analyzed. RESULTS: The six databases contained 138,625 dementia cases. Age-specific prevalences were around 30% of published estimates from community samples and incidences were around 50%. Pooled prevalences had increased from 2004 to 2012 in all age groups but pooled incidences only after age 75 years. Associations with age and gender were stable over time. DISCUSSION: The European Medical Information Framework initiative supports EHR data on unprecedented number of people with dementia. Age-specific prevalences and incidences mirror estimates from community samples in pattern at levels that are lower but increasing over time.
dc.description.sponsorship The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under European Medical Informatics Framework (EMIF) grant agreement no. 115372, resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007-2013) and European Federation of Pharmaceutical Industries and Associations (EFPIA) companies’ in kind contribution. R.S. and G.P. are partly funded by the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Alzheimer's & Dementia. 2018 Feb;14(2):130-9
dc.rights 1552-5260/ c 2017 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer’s Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.title Dementia prevalence and incidence in a federation of European Electronic Health Record databases: The European Medical Informatics Framework resource
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.jalz.2017.06.2270
dc.subject.keyword Dementia
dc.subject.keyword Electronic Health Records
dc.subject.keyword European Medical Informatics Framework
dc.subject.keyword Incidence
dc.subject.keyword Prevalence
dc.subject.keyword Demència -- Europa
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/115372
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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