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Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly

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dc.contributor.author Warren, Wesley C.
dc.contributor.author García Pérez, Raquel, 1989-
dc.contributor.author Xu, Sen
dc.contributor.author Lampert, Kathrin P.
dc.contributor.author Chapolin, Domitille
dc.contributor.author Stöck, Matthias
dc.contributor.author Loewe, Laurence
dc.contributor.author Lu, Yuan
dc.contributor.author Kuderna, Lukas, 1989-
dc.contributor.author Minx, Patrick
dc.contributor.author Montague, Michael J.
dc.contributor.author Tomlinson, Chad
dc.contributor.author Hillier, LeDeana W.
dc.contributor.author Murphy, Daniel N.
dc.contributor.author Wang, John
dc.contributor.author Wang, Zhongwei
dc.contributor.author Macias Garcia, Constantino
dc.contributor.author Thomas, Gregg C. W.
dc.contributor.author Volff, Jean-Nicolas
dc.contributor.author Farias, Fabiana
dc.contributor.author Aken, Bronwen
dc.contributor.author Walter, Ronald B.
dc.contributor.author Pruitt, Kim D.
dc.contributor.author Marquès i Bonet, Tomàs, 1975-
dc.contributor.author Hahn, Matthew W.
dc.contributor.author Kneitz, Susanne
dc.contributor.author Lynch, Michael
dc.contributor.author Schartl, Manfred
dc.date.accessioned 2018-02-14T09:44:09Z
dc.date.available 2018-02-14T09:44:09Z
dc.date.issued 2018
dc.identifier.citation Warren WC, García-Pérez R, Xu S, Lampert KP, Chalopin D, Stöck M et al. Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly. Nat Ecol Evol. 2018 Apr;2(4):669-79. DOI: 10.1038/s41559-018-0473-y
dc.identifier.issn 2397-334X
dc.identifier.uri http://hdl.handle.net/10230/33849
dc.description.abstract The extreme rarity of asexual vertebrates in nature is generally explained by genomic decay due to absence of meiotic recombination, thus leading to extinction of such lineages. We explore features of a vertebrate asexual genome, the Amazon molly, Poecilia formosa, and find few signs of genetic degeneration but unique genetic variability and ongoing evolution. We uncovered a substantial clonal polymorphism and, as a conserved feature from its interspecific hybrid origin, a 10-fold higher heterozygosity than in the sexual parental species. These characteristics seem to be a principal reason for the unpredicted fitness of this asexual vertebrate. Our data suggest that asexual vertebrate lineages are scarce not because they are at a disadvantage, but because the genomic combinations required to bypass meiosis and to make up a functioning hybrid genome are rarely met in nature.
dc.description.sponsorship This work was supported by grants to W.C.W. (NIH: 2R24OD011198-04A1), M.W.H. (NSF DBI-1564611), M.S. (German Research Foundation DFG projects Scha408/10-1 and Scha408/12-1), M.St. (Heisenberg-Fellowship STO 493/2-2 of the German Science Foundation/DFG), T.M.B.(MINECO BFU2014-55090-P (FEDER), U01 MH106874 grant, Howard Hughes International Early Career, Obra Social ‘La Caixa’ and Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya) and R.B.W. (NIH: R24OD011120). The genome annotation work carried out by NCBI was supported by the Intramural Research Program of the NIH, National Library of Medicine. The genome annotation work by Ensembl was supported by funding from the Wellcome Trust (WT108749/Z/15/Z and WT098051), the National Institutes of Health (R24 RR032658-01) and the European Molecular Biology Laboratory
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.relation.ispartof Nature Ecology and Evolution. 2018 Apr;2(4):669-79
dc.rights © Nature Publishing Group. http://dx.doi.org/10.1038/s41559-018-0473-y. https://creativecommons.org/licenses/by/4.0/
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject.other Evolució (Biologia)
dc.subject.other Genètica evolutiva
dc.subject.other Genòmica -- Evolució
dc.title Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/s41559-018-0473-y
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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