Welcome to the UPF Digital Repository

Characteristics of patients with hospital-acquired influenza A (H1N1)pdm09 virus admitted to the intensive care unit

Show simple item record

dc.contributor.author Álvarez Lerma, Francisco
dc.contributor.author Marín Corral, Judith
dc.contributor.author Vilà Vilardell, Clara
dc.contributor.author Masclans Enviz, Joan Ramon
dc.contributor.author Loeches , I. M.
dc.contributor.author Barbadillo, Sandra
dc.contributor.author González de Molina, Francisco Javier
dc.contributor.author Rodríguez, Alejandro
dc.contributor.author H1N1 GETGAG/SEMICYUC Study Group
dc.date.accessioned 2018-01-23T08:05:14Z
dc.date.available 2018-01-23T08:05:14Z
dc.date.issued 2017
dc.identifier.citation Álvarez-Lerma F, Marín-Corral J, Vilà C, Masclans JR, Loeches IM, Barbadillo S. et al. Characteristics of patients with hospital-acquired influenza A (H1N1)pdm09 virus admitted to the intensive care unit. J Hosp Infect. 2017 Feb;95(2):200-206. DOI: 10.1016/j.jhin.2016.12.017
dc.identifier.issn 0195-6701
dc.identifier.uri http://hdl.handle.net/10230/33727
dc.description.abstract BACKGROUND: Influenza A (H1N1)pdm09 virus infection acquired in the hospital and in critically ill patients admitted to the intensive care unit (ICU) has been poorly characterized. AIM: To assess the clinical impact of hospital-acquired infection with influenza A (H1N1)pdm09 virus in critically ill patients. METHODS: Analysis of a prospective database of the Spanish registry (2009-2015) of patients with severe influenza A admitted to the ICU. Infection was defined as hospital-acquired when diagnosis and starting of treatment occurred from the seventh day of hospital stay with no suspicion on hospital admission, and community-acquired when diagnosis was established within the first 48 h of admission. FINDINGS: Of 2421 patients with influenza A (H1N1)pdm09 infection, 224 (9.3%) were classified as hospital-acquired and 1103 (45.6%) as community-acquired (remaining cases unclassified). Intra-ICU mortality was higher in the hospital-acquired group (32.9% vs 18.8%, P < 0.001). Independent factors associated with mortality were hospital-acquired influenza A (H1N1)pdm09 infection (odds ratio: 1.63; 95% confidence interval: 1.37-1.99), APACHE II score on ICU admission (1.09; 1.06-1.11), underlying haematological disease (3.19; 1.78-5.73), and need of extrarenal depuration techniques (4.20; 2.61-6.77) and mechanical ventilation (4.34; 2.62-7.21). CONCLUSION: Influenza A (H1N1)pdm09 infection acquired in the hospital is an independent factor for death in critically ill patients admitted to the ICU.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights © Elsevier http://dx.doi.org/10.1016/j.jhin.2016.12.017 . https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.other Infeccions nosocomials
dc.subject.other Virus
dc.title Characteristics of patients with hospital-acquired influenza A (H1N1)pdm09 virus admitted to the intensive care unit
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.jhin.2016.12.017
dc.subject.keyword Community-acquired infections
dc.subject.keyword Critically ill
dc.subject.keyword H1N1 subtype
dc.subject.keyword Infuenza A virus
dc.subject.keyword Mortality
dc.subject.keyword Nosocomial infection
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account


Compliant to Partaking