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dc.contributor.author | Álvarez Lerma, Francisco |
dc.contributor.author | Marín Corral, Judith |
dc.contributor.author | Vilà Vilardell, Clara |
dc.contributor.author | Masclans Enviz, Joan Ramon |
dc.contributor.author | Loeches, I. M. |
dc.contributor.author | Barbadillo, Sandra |
dc.contributor.author | González de Molina, Francisco Javier |
dc.contributor.author | Rodríguez, Alejandro |
dc.contributor.author | H1N1 GETGAG/SEMICYUC Study Group |
dc.date.accessioned | 2018-01-23T08:05:14Z |
dc.date.available | 2018-01-23T08:05:14Z |
dc.date.issued | 2017 |
dc.identifier.citation | Álvarez-Lerma F, Marín-Corral J, Vilà C, Masclans JR, Loeches IM, Barbadillo S et al. Characteristics of patients with hospital-acquired influenza A (H1N1)pdm09 virus admitted to the intensive care unit. J Hosp Infect. 2017 Feb;95(2):200-6. DOI: 10.1016/j.jhin.2016.12.017 |
dc.identifier.issn | 0195-6701 |
dc.identifier.uri | http://hdl.handle.net/10230/33727 |
dc.description.abstract | BACKGROUND: Influenza A (H1N1)pdm09 virus infection acquired in the hospital and in critically ill patients admitted to the intensive care unit (ICU) has been poorly characterized. AIM: To assess the clinical impact of hospital-acquired infection with influenza A (H1N1)pdm09 virus in critically ill patients. METHODS: Analysis of a prospective database of the Spanish registry (2009-2015) of patients with severe influenza A admitted to the ICU. Infection was defined as hospital-acquired when diagnosis and starting of treatment occurred from the seventh day of hospital stay with no suspicion on hospital admission, and community-acquired when diagnosis was established within the first 48 h of admission. FINDINGS: Of 2421 patients with influenza A (H1N1)pdm09 infection, 224 (9.3%) were classified as hospital-acquired and 1103 (45.6%) as community-acquired (remaining cases unclassified). Intra-ICU mortality was higher in the hospital-acquired group (32.9% vs 18.8%, P < 0.001). Independent factors associated with mortality were hospital-acquired influenza A (H1N1)pdm09 infection (odds ratio: 1.63; 95% confidence interval: 1.37-1.99), APACHE II score on ICU admission (1.09; 1.06-1.11), underlying haematological disease (3.19; 1.78-5.73), and need of extrarenal depuration techniques (4.20; 2.61-6.77) and mechanical ventilation (4.34; 2.62-7.21). CONCLUSION: Influenza A (H1N1)pdm09 infection acquired in the hospital is an independent factor for death in critically ill patients admitted to the ICU. |
dc.format.mimetype | application/pdf |
dc.language.iso | eng |
dc.publisher | Elsevier |
dc.relation.ispartof | Journal of Hospital Infection. 2017 Feb;95(2):200-6 |
dc.rights | © Elsevier http://dx.doi.org/10.1016/j.jhin.2016.12.017 . https://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.subject.other | Infeccions nosocomials |
dc.subject.other | Virus |
dc.title | Characteristics of patients with hospital-acquired influenza A (H1N1)pdm09 virus admitted to the intensive care unit |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | http://dx.doi.org/10.1016/j.jhin.2016.12.017 |
dc.subject.keyword | Community-acquired infections |
dc.subject.keyword | Critically ill |
dc.subject.keyword | H1N1 subtype |
dc.subject.keyword | Infuenza A virus |
dc.subject.keyword | Mortality |
dc.subject.keyword | Nosocomial infection |
dc.rights.accessRights | info:eu-repo/semantics/openAccess |
dc.type.version | info:eu-repo/semantics/publishedVersion |