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Characteristics of patients with hospital-acquired influenza A (H1N1)pdm09 virus admitted to the intensive care unit

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dc.contributor.author Álvarez Lerma, Francisco
dc.contributor.author Marín Corral, Judith
dc.contributor.author Vilà Vilardell, Clara
dc.contributor.author Masclans Enviz, Joan Ramon
dc.contributor.author Loeches , I. M.
dc.contributor.author Barbadillo, Sandra
dc.contributor.author González de Molina, Francisco Javier
dc.contributor.author Rodríguez, Alejandro
dc.contributor.author H1N1 GETGAG/SEMICYUC Study Group
dc.date.accessioned 2018-01-23T08:05:14Z
dc.date.available 2018-01-23T08:05:14Z
dc.date.issued 2017
dc.identifier.citation Álvarez-Lerma F, Marín-Corral J, Vilà C, Masclans JR, Loeches IM, Barbadillo S. et al. Characteristics of patients with hospital-acquired influenza A (H1N1)pdm09 virus admitted to the intensive care unit. J Hosp Infect. 2017 Feb;95(2):200-206. DOI: 10.1016/j.jhin.2016.12.017
dc.identifier.issn 0195-6701
dc.identifier.uri http://hdl.handle.net/10230/33727
dc.description.abstract BACKGROUND: Influenza A (H1N1)pdm09 virus infection acquired in the hospital and in critically ill patients admitted to the intensive care unit (ICU) has been poorly characterized. AIM: To assess the clinical impact of hospital-acquired infection with influenza A (H1N1)pdm09 virus in critically ill patients. METHODS: Analysis of a prospective database of the Spanish registry (2009-2015) of patients with severe influenza A admitted to the ICU. Infection was defined as hospital-acquired when diagnosis and starting of treatment occurred from the seventh day of hospital stay with no suspicion on hospital admission, and community-acquired when diagnosis was established within the first 48 h of admission. FINDINGS: Of 2421 patients with influenza A (H1N1)pdm09 infection, 224 (9.3%) were classified as hospital-acquired and 1103 (45.6%) as community-acquired (remaining cases unclassified). Intra-ICU mortality was higher in the hospital-acquired group (32.9% vs 18.8%, P < 0.001). Independent factors associated with mortality were hospital-acquired influenza A (H1N1)pdm09 infection (odds ratio: 1.63; 95% confidence interval: 1.37-1.99), APACHE II score on ICU admission (1.09; 1.06-1.11), underlying haematological disease (3.19; 1.78-5.73), and need of extrarenal depuration techniques (4.20; 2.61-6.77) and mechanical ventilation (4.34; 2.62-7.21). CONCLUSION: Influenza A (H1N1)pdm09 infection acquired in the hospital is an independent factor for death in critically ill patients admitted to the ICU.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights © Elsevier http://dx.doi.org/10.1016/j.jhin.2016.12.017 . https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.other Infeccions nosocomials
dc.subject.other Virus
dc.title Characteristics of patients with hospital-acquired influenza A (H1N1)pdm09 virus admitted to the intensive care unit
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.jhin.2016.12.017
dc.subject.keyword Community-acquired infections
dc.subject.keyword Critically ill
dc.subject.keyword H1N1 subtype
dc.subject.keyword Infuenza A virus
dc.subject.keyword Mortality
dc.subject.keyword Nosocomial infection
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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