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Impact of prenatal exposure to cadmium on cognitive development at preschool age and the importance of selenium and iodine

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dc.contributor.author Kippler, Maria
dc.contributor.author Bottai, Mateo
dc.contributor.author Georgiou, Vaggelis
dc.contributor.author Koutra, Katerina
dc.contributor.author Chalkiadaki, Georgia
dc.contributor.author Kampouri, Mariza
dc.contributor.author Kyriklaki, Andriani
dc.contributor.author Vafeiadi, Marina, 1983-
dc.contributor.author Fthenou, Eleni
dc.contributor.author Vassilaki, Maria
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Vahter, Marie
dc.contributor.author Chatzi, Leda
dc.date.accessioned 2017-06-26T10:09:25Z
dc.date.available 2017-06-26T10:09:25Z
dc.date.issued 2016
dc.identifier.citation Kippler M, Bottai M, Georgiou V, Koutra K, Chalkiadaki G, Kampouri M et al. Impact of prenatal exposure to cadmium on cognitive development at preschool age and the importance of selenium and iodine. Eur J Epidemiol. 2016 Nov; 31(11): 1123-1134. DOI: 10.1007/s10654-016-0151-9
dc.identifier.issn 0393-2990
dc.identifier.uri http://hdl.handle.net/10230/32463
dc.description.abstract The evidence regarding a potential link of low-to-moderate iodine deficiency, selenium status, and cadmium exposure during pregnancy with neurodevelopment is either contradicting or limited. We aimed to assess the prenatal impact of cadmium, selenium, and iodine on children's neurodevelopment at 4 years of age. The study included 575 mother-child pairs from the prospective "Rhea" cohort on Crete, Greece. Exposure to cadmium, selenium and iodine was assessed by concentrations in the mother's urine during pregnancy (median 13 weeks), measured by ICPMS. The McCarthy Scales of Children's Abilities was used to assess children's general cognitive score and seven different sub-scales. In multivariable-adjusted regression analysis, elevated urinary cadmium concentrations (≥0.8 µg/L) were inversely associated with children's general cognitive score [mean change: -6.1 points (95 % CI -12; -0.33) per doubling of urinary cadmium; corresponding to ~0.4 SD]. Stratifying by smoking status (p for interaction 0.014), the association was restricted to smokers. Urinary selenium was positively associated with children's general cognitive score [mean change: 2.2 points (95 % CI -0.38; 4.8) per doubling of urinary selenium; ~0.1 SD], although the association was not statistically significant. Urinary iodine (median 172 µg/L) was not associated with children's general cognitive score. In conclusion, elevated cadmium exposure in pregnancy of smoking women was inversely associated with the children's cognitive function at pre-school age. The results indicate that cadmium may adversely affect neurodevelopment at doses commonly found in smokers, or that there is an interaction with other toxicants in tobacco smoke. Additionally, possible residual confounding cannot be ruled out.
dc.description.sponsorship The “Rhea” project was financially supported by European projects (EU FP6-2003-Food-3-NewGeneris, EU FP6. STREP Hiwate, EU FP7 ENV.2007.1.2.2.2. Project No 211250 Escape, EU FP7-2008-ENV-1.2.1.4 Envirogenomarkers, EU FP7-HEALTH-2009-single stage CHICOS, EU FP7 ENV.2008.1.2.1.6. Proposal No 226285 ENRIECO, EU-FP7-HEALTH-2012 Proposal No 308333 HELIX) and the Greek Ministry of Health (Program of Prevention of obesity and neurodevelopmental disorders in preschool children, in Heraklion district, Crete, Greece: 2011–2014; “Rhea Plus”: Primary Prevention Program of Environmental Risk Factors for Reproductive Health, and Child Health: 2012–2015). The present study was also funded by Karolinska Institutet, the Swedish Research Council Formas (Project No. 210-2013-751), and Swedish Research Council
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher SpringerOpen
dc.rights © The Author(s) 2016. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Dones embarassades -- Consum de tabac
dc.subject.other Iode
dc.subject.other Seleni
dc.subject.other Cadmi
dc.subject.other Orina -- Anàlisi
dc.subject.other Infants -- Desenvolupament
dc.title Impact of prenatal exposure to cadmium on cognitive development at preschool age and the importance of selenium and iodine
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1007/s10654-016-0151-9
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/16320
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/36224
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/211250
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226756
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/241604
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/226285
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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