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dc.contributor.author Ruiz Orera, Jorge, 1988-
dc.contributor.author Messeguer, Xavier
dc.contributor.author Subirana, Juan A.
dc.contributor.author Albà Soler, Mar
dc.date.accessioned 2017-06-09T07:28:04Z
dc.date.available 2017-06-09T07:28:04Z
dc.date.issued 2014
dc.identifier.citation Ruiz-Orera J, Messeguer X, Subirana JA, Alba MM. Long non-coding RNAs as a source of new peptides. Elife. 2014 Sep 16;3:e03523. DOI: 10.7554/eLife.03523
dc.identifier.issn 2050-084X
dc.identifier.uri http://hdl.handle.net/10230/32245
dc.description.abstract Deep transcriptome sequencing has revealed the existence of many transcripts that lack long or conserved open reading frames (ORFs) and which have been termed long non-coding RNAs (lncRNAs). The vast majority of lncRNAs are lineage-specific and do not yet have a known function. In this study, we test the hypothesis that they may act as a repository for the synthesis of new peptides. We find that a large fraction of the lncRNAs expressed in cells from six different species is associated with ribosomes. The patterns of ribosome protection are consistent with the translation of short peptides. lncRNAs show similar coding potential and sequence constraints than evolutionary young protein coding sequences, indicating that they play an important role in de novo protein evolution
dc.description.sponsorship This work was funded by Ministerio de Economía y Competitividad (BFU2012-36820 and TIN2013-45732-C4-3-P) and Fundació ICREA (MMA)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher eLife
dc.relation.ispartof Elife. 2014 Sep 16;3:e03523
dc.rights © Jorge Ruiz-Orera et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject.other RNA no missatgers
dc.subject.other Pèptids
dc.subject.other Proteïnes -- Síntesi
dc.subject.other Genètica
dc.title Long non-coding RNAs as a source of new peptides
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.7554/eLife.03523
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/BFU2012-36820
dc.relation.projectID info:eu-repo/grantAgreement/ES/1PE/TIN2013-45732-C4-3-P
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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