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Dual Role of Natural Killer Cells on Graft Rejection and Control of Cytomegalovirus Infection in Renal Transplantation

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dc.contributor.author López-Botet, Miguel
dc.contributor.author Vilches, Carlos
dc.contributor.author Redondo Pachón, María Dolores
dc.contributor.author Muntasell i Castellví, Aura, 1972-
dc.contributor.author Pupuleku, Aldi, 1985-
dc.contributor.author Yélamos López, José
dc.contributor.author Pascual Santos, Julio
dc.contributor.author Crespo Barrio, Marta
dc.date.accessioned 2017-05-09T08:12:04Z
dc.date.available 2017-05-09T08:12:04Z
dc.date.issued 2017
dc.identifier.citation López-Botet M, Vilches C, Redondo Pachón MD, Muntasell i Castellví A, Pupuleku A, Yelamos López J et al. Dual Role of Natural Killer Cells on Graft Rejection and Control of Cytomegalovirus Infection in Renal Transplantation. Frontiers in Immunology. 2017;8(FEB):166. DOI: 10.3389/fimmu.2017.00166
dc.identifier.issn 1664-3224
dc.identifier.uri http://hdl.handle.net/10230/32112
dc.description.abstract Allograft rejection constitutes a major complication of solid organ transplantation requiring prophylactic/therapeutic immunosuppression, which increases susceptibility of patients to infections and cancer. Beyond the pivotal role of alloantigen-specific T cells and antibodies in the pathogenesis of rejection, natural killer (NK) cells may display alloreactive potential in case of mismatch between recipient inhibitory killer-cell immunoglobulin-like receptors (KIRs) and graft HLA class I molecules. Several studies have addressed the impact of this variable in kidney transplant with conflicting conclusions; yet, increasing evidence supports that alloantibody-mediated NK cell activation via FcγRIIIA (CD16) contributes to rejection. On the other hand, human cytomegalovirus (HCMV) infection constitutes a risk factor directly associated with the rate of graft loss and reduced host survival. The levels of HCMV-specific CD8+ T cells have been reported to predict the risk of posttransplant infection, and KIR-B haplotypes containing activating KIR genes have been related with protection. HCMV infection promotes to a variable extent an adaptive differentiation and expansion of a subset of mature NK cells, which display the CD94/NKG2C-activating receptor. Evidence supporting that adaptive NKG2C+ NK cells may contribute to control the viral infection in kidney transplant recipients has been recently obtained. The dual role of NK cells in the interrelation of HCMV infection with rejection deserves attention. Further phenotypic, functional, and genetic analyses of NK cells may provide additional insights on the pathogenesis of solid organ transplant complications, leading to the development of biomarkers with potential clinical value.
dc.description.sponsorship The authors are supported by a coordinated research project from Fundació La Marató de TV3 (137/C/2012) and by grants from: Plan Estatal I+D Retos (SAF2013-49063-C2-1-R), Spanish Ministry of Economy and Competitiveness (MINECO, FEDER); EU FP7-MINECO Infect-ERA program (PCIN-2015-191-C02-01); FIS-FEDER PI13/00598 and 16/00617, Intensification Programs (Spanish Ministry of Health ISCIII); and RedinRen RD16/0009/0013. AM is supported by Asociación Española Contra el Cáncer (AECC). AP is supported by EU-FP7 Marie Curie Training Network (NATURIMMUN FP7-PEOPLE-2012-ITN-317013).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Frontiers
dc.relation.ispartof Frontiers in Immunology. 2017;8(FEB):166
dc.rights © 2017 López-Botet, Vilches, Redondo-Pachón, Muntasell, Pupuleku, Yélamos, Pascual and Crespo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.title Dual Role of Natural Killer Cells on Graft Rejection and Control of Cytomegalovirus Infection in Renal Transplantation
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3389/fimmu.2017.00166
dc.subject.keyword Human
dc.subject.keyword Natural killer
dc.subject.keyword Cytomegalovirus
dc.subject.keyword Renal
dc.subject.keyword Transplantation
dc.subject.keyword Rejection
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/317013
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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