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Evaluating the importance of mitotic asymmetry in cyton-based models for FSE-based flow cytometry data

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dc.contributor.author Banks, H. Thomas
dc.contributor.author Kapraun, Dustin F.
dc.contributor.author Peligero Cruz, Cristina, 1986-
dc.contributor.author Argilaguet Marqués, Jordi, 1977-
dc.contributor.author Meyerhans, Andreas
dc.date.accessioned 2017-03-08T13:04:11Z
dc.date.available 2017-03-08T13:04:11Z
dc.date.issued 2015
dc.identifier.citation Banks HT, Kapraun DF, Peligero Cruz C, Argilaguet J, Meyerhans A. Evaluating the importance of mitotic asymmetry in cyton-based models for FSE-based flow cytometry data. International Journal of Pure and Applied Mathematics. 2015; 100(1): 131-156. DOI: 10.12732/ijpam.v100i1.12
dc.identifier.issn 1311-8080
dc.identifier.uri http://hdl.handle.net/10230/28190
dc.description.abstract We carry out computational inverse problem investigations to determine the importance of allowing for unequal label allocation to daughter cells during mitosis. Parameter estimations are performed using previously developed label-structured partial differential equation models that utilize “cytons” to account for variability in times between cell divisions as well as times until cell death. These models are augmented to allow for asymmetric cell divisions through inclusion of an additional model parameter. We employ well-known model comparison tests to analyze CFSE-based flow cytometry data with respect to the importance of asymmetric division during proliferation of human CD4+ and CD8+ T cells.
dc.description.sponsorship This research was supported in part (HTB) by the Air Force Office of Scientific Research under grant number AFOSR FA9550-12-1-0188, and in part (DFK) by the National Science Foundation under Research Training Grant (RTG) DMS-0636590. CP, JA and AM were supported by grant SAF2010-21336 from the Spanish Ministry of Science and Innovation.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Academic Publications
dc.relation.ispartof International Journal of Pure and Applied Mathematics. 2015; 100(1): 131-156
dc.rights This work is licensed under the Creative Commons Attribution International License (CC BY).
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.title Evaluating the importance of mitotic asymmetry in cyton-based models for FSE-based flow cytometry data
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.12732/ijpam.v100i1.12
dc.subject.keyword Cell proliferation
dc.subject.keyword Flow cytometry
dc.subject.keyword CFSE
dc.subject.keyword Partial differential equations
dc.subject.keyword Label-structured populations dynamics
dc.subject.keyword Cell division number
dc.subject.keyword Inverse problems
dc.subject.keyword Asymmetric cell division
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2010-21336
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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