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Metabolites of glutamate metabolism are associated with incident cardiovascular events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) Trial.

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dc.contributor.author Zheng, Yan
dc.contributor.author Hu, Frank B.
dc.contributor.author Ruiz-Canela, Miguel
dc.contributor.author Clish, Clary B.
dc.contributor.author Dennis, Courtney
dc.contributor.author Salas-Salvadó, Jordi
dc.contributor.author Hruby, Adela
dc.contributor.author Liang, Liming
dc.contributor.author Toledo, Estefania
dc.contributor.author Corella, Dolores
dc.contributor.author Ros, Emilio
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Gómez-Gracia, Enrique
dc.contributor.author Arós, Fernando
dc.contributor.author Fiol, Miquel
dc.contributor.author Lapetra, José
dc.contributor.author Serra-Majem, Luis
dc.contributor.author Estruch, Ramón
dc.contributor.author Martínez-González, Miguel A.
dc.date.accessioned 2017-01-13T11:31:05Z
dc.date.available 2017-01-13T11:31:05Z
dc.date.issued 2016
dc.identifier.citation Zheng Y, Hu F, Ruiz-Canela M, Clish CB, Dennis C, Salas-Salvado J. et al . Metabolites of glutamate metabolism are associated with incident cardiovascular events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) Trial. JAHA. 2016;5(9)
dc.identifier.issn 2047-9980
dc.identifier.uri http://hdl.handle.net/10230/27889
dc.description.abstract BACKGROUND: Glutamate metabolism may play a role in the pathophysiology of cardiometabolic disorders. However, there is limited evidence of an association between glutamate-related metabolites and, moreover, changes in these metabolites, and risk of cardiovascular disease (CVD). METHODS AND RESULTS: Plasma levels of glutamate and glutamine were measured at baseline and 1-year follow-up in a case-cohort study including 980 participants (mean age 68 years; 46% male) from the PREvención con DIeta MEDiterránea (PREDIMED) randomized trial, which assessed a Mediterranean diet intervention in the primary prevention of CVD. During median 4.8 years of follow-up, there were 229 incident CVD events (nonfatal stroke, nonfatal myocardial infarction, or CVD death). In fully adjusted models, per 1-SD, baseline glutamate was associated with 43% (95% CI: 16% to 76%) and 81% (39% to 137%) increased risk of composite CVD and stroke alone, respectively, and baseline glutamine-to-glutamate ratio with 25% (6% to 40%) and 44% (25% to 58%) decreased risk of composite CVD and stroke alone, respectively. Associations appeared linear for stroke (both Plinear trend≤0.005). Among participants with high baseline glutamate, the interventions lowered CVD risk by 37% compared to the control diet; the intervention effects were not significant when baseline glutamate was low (Pinteraction=0.02). No significant effect of the intervention on year-1 changes in metabolites was observed, and no effect of changes themselves on CVD risk was apparent. CONCLUSIONS: Baseline glutamate was associated with increased CVD risk, particularly stroke, and glutamine-to-glutamate ratio was associated with decreased risk. Participants with high glutamate levels may obtain greater benefits from the Mediterranean diet than those with low levels.
dc.description.sponsorship This work was supported by the National Institutes of Health, 1R01HL118264. The PREDIMED trial was supported by the official funding agency for Biomedical Research of the Spanish Government, Instituto de Salud Carlos III, through grants provided to research networks specifically developed for the trial: RTIC G03/140 (Period 2003–2006, Coordinator: R. Estruch, MD, PhD), and RTIC RD 06/0045 (Period 2007–2013, Coordinator: M. A. Martinez-Gonzalez, MD, PhD). We also acknowledge the grants from Centro Nacional de Investigaciones Cardiovasculares CNIC06/2007,Fondo de Investigaci on Sanitaria—Fondo Europeo de Desarrollo Regional (PI04-2239, PI05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI08/1259, PI10/01407, PI11/01647, PI11/01791), and Consejer ıa de Salud de la Junta de Andaluc ıa (PI0105/2007). Ministerio de Ciencia e Innovaci on (AGL-2009- 13906-C02, AGL2010-22319-C03), Fundaci on Mapfre 2010, Consejeria de Salud de la Junta de Andalucia (PI0105/2007), Agencia Canaria de Investigaci on, Innovaci on y Sociedad de la Informaci on-EU FEDER (PI 2007/050), Public Health Division of the Department of Health of the Autonomous Government of Catalonia and Generalitat Valenciana (ACOMP06109, GVACOMP2010-181, GVACOMP2011-151, CS2010-AP-111, CS2011-AP-042, AP-042/11 and BEST11-263) and Ministerio de Econom ıa (PI07-0954, CNIC-06, AGL2010-22319-C03-03, PI11/02505). CIBEROBN is an initiative of ISCIII, Spain.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Willey
dc.relation.ispartof Journal of the American Heart Association. 2016;5(9)
dc.rights © 2016 The Authors and The Broad Institute. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the https://creativecommons.org/licenses/by-nc/4.0/, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0/
dc.subject.other Sistema cardiovascular -- Malalties -- Dietoteràpia
dc.subject.other Dieta -- Mediterrània, Regió de la
dc.title Metabolites of glutamate metabolism are associated with incident cardiovascular events in the PREDIMED PREvención con DIeta MEDiterránea (PREDIMED) Trial.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1161/JAHA.116.003755
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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