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Endosomal acidification inhibitors for the treatment of BRAF mutant tumors.

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dc.contributor.author Espinosa Blay, Lluís
dc.date.accessioned 2017-01-09T11:07:23Z
dc.date.available 2017-01-09T11:07:23Z
dc.date.issued 2016
dc.identifier.citation Espinosa L. Endosomal acidification inhibitors for the treatment of BRAF mutant tumors. Mol Cell Oncol. 2015 Nov 18;3(2):e1062073. doi: 10.1080/23723556.2015.1062073
dc.identifier.issn 2372-3556
dc.identifier.uri http://hdl.handle.net/10230/27854
dc.description.abstract Mutations in KRAS and BRAF genes are commonly found in several types of cancer associated with poor prognosis and therapy resistance. We have identified phosphorylated p45-IKKα as an essential mediator of BRAF-induced tumorigenesis. Importantly, endosomal acidification inhibitors preclude phosphorylation of p45-IKKα and abolish the metastatic capacity of BRAF mutant cancer cells.
dc.description.sponsorship This work has been supported by Fundaci o La Marat o de TV3 with grant # 20131210 and Instituto de Salud Carlos III-FEDER with grant # PI13/ 00448
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Taylor & Francis
dc.rights This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
dc.rights.uri https://creativecommons.org/licenses/by-nc/3.0/
dc.subject.other Còlon -- Càncer
dc.subject.other Còlon -- Tumors
dc.title Endosomal acidification inhibitors for the treatment of BRAF mutant tumors.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1080/23723556.2015.1062073
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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