Endosomal acidification inhibitors for the treatment of BRAF mutant tumors.

Espinosa Blay, Lluís

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Endosomal acidification inhibitors for the treatment of BRAF mutant tumors.

Document Type: Article

Version: Published version

Date: 2016

This document is associated with a Creative Common license

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Citation: Espinosa L. Endosomal acidification inhibitors for the treatment of BRAF mutant tumors. Mol Cell Oncol. 2015 Nov 18;3(2):e1062073. doi: 10.1080/23723556.2015.1062073

Permanent link: http://hdl.handle.net/10230/27854

Abstract:

Mutations in KRAS and BRAF genes are commonly found in several types of cancer associated with poor prognosis and therapy resistance. We have identified phosphorylated p45-IKKα as an essential mediator of BRAF-induced tumorigenesis. Importantly, endosomal acidification inhibitors preclude phosphorylation of p45-IKKα and abolish the metastatic capacity of BRAF mutant cancer cells.

Author: Espinosa Blay, Lluís

DOI: http://dx.doi.org/10.1080/23723556.2015.1062073

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