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Breast cancer risk and night shift work in a case-control study in a Spanish population

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dc.contributor.author Papantoniou, Kyriaki, 1983-
dc.contributor.author Castaño Vinyals, Gemma
dc.contributor.author Espinosa Díaz, Ana
dc.contributor.author Aragonés, Núria
dc.contributor.author Pérez-Gómez, Beatriz
dc.contributor.author Ardanaz Aicua, Eva
dc.contributor.author Altzibar, Jone Miren
dc.contributor.author Martín Sánchez, Vicente
dc.contributor.author Gómez-Acebo, Inés
dc.contributor.author Llorca, Javier
dc.contributor.author Muñoz, David
dc.contributor.author Tardón, Adonina
dc.contributor.author Peiró, Rosana
dc.contributor.author Marcos-Gragera, Rafael
dc.contributor.author Pollan, Marina
dc.contributor.author Kogevinas, Manolis
dc.date.accessioned 2017-01-04T08:27:31Z
dc.date.issued 2016
dc.identifier.citation Papantoniou K, Castaño-Vinyals G, Espinosa A, Aragonés N, Pérez-Gómez B, Ardanaz E et al. Breast cancer risk and night shift work in a case-control study in a Spanish population. Eur J Epidemiol. 2016 Sep;31(9):867-78. DOI: 10.1007/s10654-015-0073-y
dc.identifier.issn 0393-2990
dc.identifier.uri http://hdl.handle.net/10230/27847
dc.description.abstract Epidemiologic and animal data indicate that night shift work might increase the risk for breast cancer. We evaluated the association of night work with different clinical types of breast cancer in a population based case-control study (MCC-Spain study) taking into account chronotype, an individual characteristic that may relate to night shift work adaptation. Lifetime occupational history was assessed by face-to-face interviews and shift work information was available for 1708 breast cancer cases and 1778 population controls from 10 Spanish regions, enrolled from 2008 to 2013. We evaluated three shift work domains, including shift work type (permanent vs rotating), lifetime cumulative duration and frequency. We estimated odds ratios (OR) for night work compared to day work using unconditional logistic regression models adjusting for confounders. Having ever worked permanent or rotating night shift was associated with an increased risk for breast cancer compared to day workers [odds ratio (OR) 1.18; 95 % CI 0.97, 1.43]. Chronotype was differentially associated with breast cancer depending on the duration of night shift work. Risk was higher in women with invasive tumors (OR 1.23; 95 % CI 1.00, 1.51) and for estrogen and progestagen positive tumors among premenopausal women (OR 1.44; 95 % CI 1.05, 1.99). Having ever performed night shift was associated with a small increased risk for breast cancer and especially in subgroups of women with particular hormone related characteristics.
dc.description.sponsorship The study was funded by the ‘‘Acción Transversal del Cáncer’’, approved on the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PI09/00773-Cantabria, PI09/01286-León, PI09/01903-Valencia, PI09/02078-Huelva, PI09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL (The ICGC/nCLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)), by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (2009-S0143), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP 00310), by the European Commission Grants FOOD-CT-2006-036224-HIWATE, by the Spanish Association Against Cancer (AECC) Scientific Foundation, by the Catalan Government DURSI Grant 2009SGR1489, and by a predoctoral Grant PFIS (FI09/00385)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof European Journal of Epidemiology. 2016 Sep;31(9):867-78
dc.rights © Springer. The final publication is available at Springer via/nhttp://dx.doi.org/10.1007/s10654-015-0073-y
dc.subject.other Mama -- Càncer
dc.title Breast cancer risk and night shift work in a case-control study in a Spanish population
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1007/s10654-015-0073-y
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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