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Lack of Postprandial Peak in Brain-Derived Neurotrophic Factor in Adults with Prader-Willi Syndrome.

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dc.contributor.author Bueno, Marta
dc.contributor.author Esteba-Castillo, Susanna
dc.contributor.author Novell, Ramon
dc.contributor.author Giménez Palop, Olga
dc.contributor.author Coronas, Ramon
dc.contributor.author Gabau, Elisabeth
dc.contributor.author Corripio, Raquel
dc.contributor.author Baena, Neus
dc.contributor.author Viñas-Jornet, Marina
dc.contributor.author Guitart, Miriam
dc.contributor.author Torrents-Rodas, David
dc.contributor.author Deus, Joan
dc.contributor.author Pujol Martí, Jesús, 1981-
dc.contributor.author Rigla, Mercedes
dc.contributor.author Caixàs, Assumpta
dc.date.accessioned 2016-11-28T08:23:58Z
dc.date.available 2016-11-28T08:23:58Z
dc.date.issued 2016
dc.identifier.citation Bueno M, Esteba-Castillo S, Novell R, Giménez-Palop O, Coronas R, Gabau E. et al. ack of Postprandial Peak in Brain-Derived Neurotrophic Factor in Adults with Prader-Willi Syndrome. PLoS One. 2016 Sep 29;11(9):e0163468. doi: 10.1371/journal.pone
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/27615
dc.description.abstract CONTEXT: Prader-Willi syndrome (PWS) is characterized by severe hyperphagia. Brain-derived neurotrophic factor (BDNF) and leptin are reciprocally involved in energy homeostasis. OBJECTIVES: To analyze the role of BDNF and leptin in satiety in genetic subtypes of PWS. DESIGN: Experimental study. SETTING: University hospital. SUBJECTS: 90 adults: 30 PWS patients; 30 age-sex-BMI-matched obese controls; and 30 age-sex-matched lean controls. INTERVENTIONS: Subjects ingested a liquid meal after fasting ≥10 hours. MAIN OUTCOME MEASURES: Leptin and BDNF levels in plasma extracted before ingestion and 30', 60', and 120' after ingestion. Hunger, measured on a 100-point visual analogue scale before ingestion and 60' and 120' after ingestion. RESULTS: Fasting BDNF levels were lower in PWS than in controls (p = 0.05). Postprandially, PWS patients showed only a truncated early peak in BDNF, and their BDNF levels at 60' and 120' were lower compared with lean controls (p<0.05). Leptin was higher in PWS patients than in controls at all time points (p<0.001). PWS patients were hungrier than controls before and after eating. The probability of being hungry was associated with baseline BDNF levels: every 50-unit increment in BDNF decreased the odds of being hungry by 22% (OR: 0.78, 95%CI: 0.65-0.94). In uniparental disomy, the odds of being hungry decreased by 66% (OR: 0.34, 90%CI: 0.13-0.9). Postprandial leptin patterns did no differ among genetic subtypes. CONCLUSIONS: Low baseline BDNF levels and lack of postprandial peak may contribute to persistent hunger after meals. Uniparental disomy is the genetic subtype of PWS least affected by these factors.
dc.description.sponsorship This project was supported by a grant from Fondo de Investigacio´n Sanitaria del Instituto Carlos III (PI-14/02057), and by two grants from Fundacio´ Parc Taulı´(CIR 2010/006 and CIR 2011/004), all to AC.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS) 
dc.relation.ispartof PLoS One. 2016 Sep 29;11(9):e0163468
dc.rights © 2016 Bueno et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri https://creativecommons.org/licenses/by/4.0/
dc.subject.other Prader-Willi Syndrome
dc.title Lack of Postprandial Peak in Brain-Derived Neurotrophic Factor in Adults with Prader-Willi Syndrome.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0163468
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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