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Metabolic disposition and biological significance of simple phenols of dietary origin: hydroxytyrosol and tyrosol.

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dc.contributor.author Rodríguez-Morató, Jose, 1987-
dc.contributor.author Boronat Rigol, Anna
dc.contributor.author Kotronoulas, Aristotelis
dc.contributor.author Pujadas Bastardes, Mitona
dc.contributor.author Pastor, Antonio
dc.contributor.author Olesti Muñoz, Eulàlia
dc.contributor.author Pérez Mañá, Clara
dc.contributor.author Khymenets, Olha, 1974-
dc.contributor.author Fitó Colomer, Montserrat
dc.contributor.author Farré Albaladejo, Magí
dc.contributor.author Torre Fornell, Rafael de la
dc.date.accessioned 2016-07-14T10:34:04Z
dc.date.issued 2016
dc.identifier.citation Rodríguez-Morató J, Boronat A, Kotronoulas, Pujadas M, Pastor A, Olesti E. et al. Metabolic disposition and biological significance of simple phenols of dietary origin: hydroxytyrosol and tyrosol. Drug Metab Rev. 2016 May;48(2):218-36. doi: 10.1080/03602532.2016.1179754
dc.identifier.issn 0360-2532
dc.identifier.uri http://hdl.handle.net/10230/27050
dc.description.abstract Hydroxytyrosol and tyrosol are dietary phenolic compounds present in virgin olive oil and wine. Both compounds are also endogenously synthesized in our body as byproducts of dopamine and tyramine metabolisms, respectively. Over the last decades, research into hydroxytyrosol and tyrosol has experienced an increasing interest due to the role that these compounds may play in the prevention of certain pathologies (e.g. cardiovascular, metabolic, neurodegenerative diseases and cancer). The translation of promising in vitro and in vivo biological effects from preclinical studies to the context of human disease prevention initially depends on whether the dose ingested becomes available at the site of action. In this regard, information regarding the bioavailability and metabolic disposition of hydroxytyrosol and tyrosol is of most importance to evaluate the impact they may have on human health. In this review, we discuss and summarize the state of the art of the scientific evidence regarding the processes of absorption, distribution, metabolism and excretion of both hydroxytyrosol and tyrosol. We also examine the impact of these compounds and their metabolites on biological activity in terms of beneficial health effects. Finally, we evaluate the different analytical approaches that have been developed to measure the plasma and urinary levels of hydroxytyrosol, tyrosol and their metabolites.
dc.description.sponsorship This work was supported by grants from Instituto de Salud Carlos III FEDER, (PI14/00072) and from DIUE de la Generalitat de Catalunya (2014SGR 680). JRM was supported by a FI-DGR2012 predoctoral fellowship from the Generalitat de Catalunya and CPM was supported by a Juan Rodes fellowship (ISCIII, JR, 15/00005). CIBER de Fisiopatologıa de la Obesidad y Nutricion (CIBEROBN) is an initiative of the Instituto de Salud Carlos III, Madrid, Spain.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Taylor & Francis
dc.rights © Taylor & Francis. This is an electronic version of an article published in odríguez-Morató J, Boronat A, Kotronoulas, Pujadas M, Pastor A, Olesti E. et al. Metabolic disposition and biological significance of simple phenols of dietary origin: hydroxytyrosol and tyrosol. Drug Metab Rev. 2016 May;48(2):218-36. Drug Metabolism Reviews is available online at: http://www.tandfonline.com/doi/full/10.1080/03602532.2016.1179754
dc.subject.other Dieta -- Mediterrània, Regió de la
dc.subject.other Fenols
dc.subject.other Sistema cardiovascular -- Malalties -- Prevenció
dc.title Metabolic disposition and biological significance of simple phenols of dietary origin: hydroxytyrosol and tyrosol.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1080/03602532.2016.1179754
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion
dc.embargo.liftdate 2018-11-30
dc.date.embargoEnd info:eu-repo/date/embargoEnd/2018-11-30


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