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The birth of a deadly yeast: tracing the evolutionary emergence of virulence traits in Candida glabrata

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dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
dc.contributor.author Carreté Muñoz, Laia, 1990-
dc.date.accessioned 2016-06-06T14:46:15Z
dc.date.available 2016-06-06T14:46:15Z
dc.date.issued 2016
dc.identifier.citation Gabaldón T, Carreté L. The birth of a deadly yeast: tracing the evolutionary emergence of virulence traits in Candida glabrata. FEMS yeast research. 2016; 16(2): fov110. DOI 10.1093/femsyr/fov110
dc.identifier.issn 1567-1356
dc.identifier.uri http://hdl.handle.net/10230/26858
dc.description.abstract The yeast Candida glabrata is an opportunistic human fungal pathogen whose incidence has increased in the last two decades. Despite its name, this yeast is only distantly related to the model fungal pathogen C. albicans, and more closely related to Saccharomyces cerevisiae and other yeasts that underwent an ancient whole-genome duplication. Understanding what specific traits make C. glabrata a successful opportunistic pathogen within a clade of mostly innocuous yeasts, and how these compare to virulence traits in distant pathogens such as C. albicans is a focus of intense research. From an evolutionary perspective, uncovering how the ability to infect humans has emerged multiple, independent times in different lineages may reveal new disease mechanisms and provide us with the capacity to predict which genomic features in a clade may confer a higher potential to develop virulence against humans.
dc.description.sponsorship TG group acknowledges support of the Spanish Ministry of Economy and Competitiveness grants, ‘Centro de Excelencia Severo Ochoa 2013–2017’ SEV-2012-0208, and BIO2012-37161 cofounded by European Regional Development Fund (ERDF); from the European Union and ERC Seventh Framework Programme (FP7/2007-2013) under grant agreements FP7-PEOPLE-2013-ITN-606786 and ERC-2012-StG-310325, and grant from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No H2020-MSCA-ITN-2014-642095.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Oxford University Press
dc.relation.ispartof FEMS yeast research. 2016; 16(2): fov110
dc.rights © FEMS 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/
dc.subject.other Llevats -- Genètica
dc.title The birth of a deadly yeast: tracing the evolutionary emergence of virulence traits in Candida glabrata
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1093/femsyr/fov110
dc.subject.keyword Candida glabrata
dc.subject.keyword Virulence
dc.subject.keyword Evolution
dc.subject.keyword Nakaseomyces
dc.subject.keyword Candida
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SEV-2012-0208
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2012-37161
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/642095
dc.relation.projectID info:eu-repo/grantAgreement/EC/ERC/310325
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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