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Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris)

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dc.contributor.author Pedersen, Marie
dc.contributor.author Mendez, Michelle A.
dc.contributor.author Espinosa Díaz, Ana
dc.contributor.author Villanueva Belmonte, Cristina
dc.contributor.author Gracia Lavedan, Esther
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Nieuwenhuijsen, Mark J.
dc.contributor.author Cirach, Marta
dc.contributor.author Agramunt, Silvia
dc.contributor.author Kogevinas, Manolis
dc.date.accessioned 2016-04-26T13:37:34Z
dc.date.available 2016-04-26T13:37:34Z
dc.date.issued 2015
dc.identifier.citation Pedersen M, Mendez MA, Schoket B, Godschalk RW, Espinosa A, Landström A et al. Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris). Environmental health perspectives. 2015; 123(4): 374-380. DOI 10.1289/ehp.1408613
dc.identifier.issn 0091-6765
dc.identifier.uri http://hdl.handle.net/10230/26174
dc.description.abstract BACKGROUND: Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk. OBJECTIVE: We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates. METHODS: Pregnant women from Greece, Spain, England, Denmark, and Norway were recruited in 2006-2010. Cord blood bulky DNA adduct levels were measured by the 32P-postlabeling technique (n = 511). Diet and maternal characteristics were assessed via questionnaires. Modeled exposures to air pollutants and drinking-water disinfection by-products, mainly trihalomethanes (THMs), were available for a large proportion of the study population. RESULTS: Greek and Spanish neonates had higher adduct levels than the northern European neonates [median, 12.1 (n = 179) vs. 6.8 (n = 332) adducts per 108 nucleotides, p < 0.001]. Residence in southern European countries, higher maternal body mass index, delivery by cesarean section, male infant sex, low maternal intake of fruits rich in vitamin C, high intake of dairy products, and low adherence to healthy diet score were statistically significantly associated with higher adduct levels in adjusted models. Exposure to fine particulate matter and nitrogen dioxide was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England. CONCLUSION: These findings suggest that a combination of factors, including unknown country-specific factors, influence the bulky DNA adduct levels in neonates.
dc.description.sponsorship The NewGeneris (FOOD-CT-2005-016320), ESCAPE (FP7-2007-211250), and HiWATE (FOOD-CT-2006-036224) studies were all funded by the European Union. M.P. holds a Juan de la Cierva postdoctoral fellowship awarded from the Spanish Ministry of Science and Innovation (JCI-2011-09479).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher National Institute of Environmental Health Sciences
dc.relation.ispartof Environmental health perspectives. 2015; 123(4): 374-380
dc.rights Reproduced with permission from Environmental Health Perspectives http://dx.doi.org/10.1289/ehp.1408613
dc.subject.other ADN
dc.subject.other Embaràs -- Aspectes nutricionals
dc.subject.other Contaminació
dc.title Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris)
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1289/ehp.1408613
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/16320
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/36224
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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