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Hyperinsulinemic Hypoglycemia after Bariatric Surgery: Diagnosis and Management Experience from a Spanish Multicenter Registry.

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dc.contributor.author Vilarrasa, Nuria
dc.contributor.author Goday Arno, Alberto
dc.contributor.author Rubio Pérez, Miguel Angel
dc.contributor.author Caixàs, Assumpta
dc.contributor.author Pellitero, Silvia
dc.contributor.author Ciudin, Andrea
dc.contributor.author Calañas, Alfonso
dc.contributor.author Botella, José Ignacio
dc.contributor.author Bretón, Irene
dc.contributor.author Morales, María José
dc.contributor.author Díaz-Fernández, María Jesús
dc.contributor.author García-Luna, Pedro Pablo
dc.contributor.author Lecube, Albert
dc.date.accessioned 2016-04-26T11:23:12Z
dc.date.available 2016-04-26T11:23:12Z
dc.date.issued 2016
dc.identifier.citation Vilarrasa N, Goday A, Rubio MA, Caixàs A, Pellitero S, Ciudin A. Hyperinsulinemic Hypoglycemia after Bariatric Surgery: Diagnosis and Management Experience from a Spanish Multicenter Registry. Obes Facts. 2016;9(1):41-51. doi: 10.1159/000442764.
dc.identifier.issn 1662-4025
dc.identifier.uri http://hdl.handle.net/10230/26171
dc.description.abstract BACKGROUND: Severe postprandial hypoglycemia after bariatric surgery is a rare but invalidating complication. Our aim was to describe the different tests performed for its diagnosis and their outcomes as well as the response to the prescribed pharmacological and surgical treatments. METHODS: Multicenter, retrospective systematic review of cases with recurrent severe postprandial hypoglycemia. RESULTS: Over 11 years of follow-up, 22 patients were identified. The test most used to provoke hypoglycemia was the oral glucose load test followed by the mixed meal test which was the least standardized test. With pharmacological treatment, 3 patients were symptom-free (with octreotide) and in 12 patients hypoglycemic episodes were attenuated. Seven patients had persistent hypoglycemic episodes and underwent surgery. Partial pancreatectomy was performed in 3 patients who had positive selective arterial calcium stimulation, and nesidioblastosis was confirmed in 2 patients. Reconversion to normal anatomy was performed in 3 patients, and 1 patient underwent a resection of the 'candy cane' roux limb, with resolution of hypoglycemia in all cases. CONCLUSIONS: There is high heterogeneity in the evaluation and treatment options for postoperative hypoglycemia. In patients that do not respond to pharmacological treatment, reconstruction of gastrojejunal continuity may be the safest and most successful procedure.
dc.description.sponsorship This work was supported by ‘ Ajuts per a projectes de recerca clínica de l’Hospital Universitari de Bellvitge (2011-PR143/11)’
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Karger
dc.relation.ispartof Obesity Facts. 2016;9(1):41-51
dc.rights This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Distribution permitted for non-commercial purposes only.
dc.rights.uri https://creativecommons.org/licenses/by-nc/4.0/
dc.subject.other Obesitat--Cirurgia
dc.subject.other Hipoglucèmia
dc.title Hyperinsulinemic Hypoglycemia after Bariatric Surgery: Diagnosis and Management Experience from a Spanish Multicenter Registry.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1159/000442764
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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