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Poly(ADP-Ribose) Polymerases: New Players in the Pathogenesis of Exocrine Pancreatic Diseases.

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dc.contributor.author Martínez Bosch, Neus
dc.contributor.author Fernández-Zapico, Martin E.
dc.contributor.author Navarro Medrano, Pilar
dc.contributor.author Yélamos López, José
dc.date.accessioned 2016-04-13T11:27:42Z
dc.date.issued 2016
dc.identifier.citation Martínez-Bosch N, Fernández-Zapico ME, Navarro P, Yélamos J. Poly(ADP-Ribose) Polymerases: New Players in the Pathogenesis of Exocrine Pancreatic Diseases. Am J Pathol. 2016 Feb;186(2):234-41. doi: 10.1016/j.ajpath.2015.09.021.
dc.identifier.issn 0002-9440
dc.identifier.uri http://hdl.handle.net/10230/26076
dc.description.abstract The poly(ADP-ribose) polymerase (PARP) enzymes were initially characterized as sensors of DNA breaks but are now known to play key roles not only in the DNA damage response but also in regulating numerous molecular processes, such as gene transcription. Furthermore, these polymerases have emerged as key players in the pathogenesis of multiple diseases, providing promising therapeutic targets for pathologies such as cardiovascular disorders, neurodegenerative diseases, and cancer. In recent years, PARPs have been implicated in the pathogenesis of pancreatitis and pancreatic cancer, and PARP inhibition has been proposed as a valuable strategy for treating these two important gastrointestinal tract disorders. For instance, in preclinical mouse models, pancreatitis was significantly attenuated after genetic or pharmacological PARP inactivation, and several clinical trials have demonstrated promising responses to PARP inhibitors in pancreatic cancer patients. In this review, we summarize the current understanding of PARP functions in these two dismal pathologies and discuss the next steps necessary to determine whether PARP inhibitors will finally make the difference in treating pancreatitis and pancreatic cancer successfully.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof The American Journal of Pathology. 2016 Feb;186(2):234-41
dc.rights Copyright © 2016 Elsevier. Martínez-Bosch N, Fernández-Zapico ME, Navarro P, Yélamos J. Poly(ADP-Ribose) Polymerases: New Players in the Pathogenesis of Exocrine Pancreatic Diseases. Am J Pathol. 2016 Feb;186(2):234-41. doi: 10.1016/j.ajpath.2015.09.021.
dc.subject.other Pàncrees -- Malalties
dc.subject.other Enzims
dc.subject.other Pancreatitis
dc.title Poly(ADP-Ribose) Polymerases: New Players in the Pathogenesis of Exocrine Pancreatic Diseases.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.ajpath.2015.09.021
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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