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Dietary total antioxidant capacity and mortality in the PREDIMED study.

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dc.contributor.author Henríquez-Sánchez, P.
dc.contributor.author Sánchez-Villegas, A.
dc.contributor.author Ruano-Rodríguez, C.
dc.contributor.author Gea, Alfredo
dc.contributor.author Lamuela-Raventós, Rosa M.
dc.contributor.author Estruch, Ramón
dc.contributor.author Salas-Salvadó, Jordi
dc.contributor.author Covas Planells, Maria Isabel
dc.contributor.author Corella, Dolores
dc.contributor.author Schröder, Helmut, 1958-
dc.contributor.author Gutierrez-Bedmar, Mario
dc.contributor.author Santos-Lozano, José
dc.contributor.author Pinto, Xavier
dc.contributor.author Arós, Fernando
dc.contributor.author Fiol, Miquel
dc.contributor.author Tresserra-Rimbau, Anna
dc.contributor.author Ros, Emilio
dc.contributor.author Martínez-González, Miguel A.
dc.contributor.author Serra-Majem, Luis
dc.contributor.author PREDIMED investigators
dc.date.accessioned 2016-02-24T12:28:53Z
dc.date.issued 2016
dc.identifier.citation Henríquez-Sánchez P, Sánchez-Villegas A, Ruano-Rodríguez C, Gea A, Lamuela-Raventós RM, Estruch R. et al. Dietary total antioxidant capacity and mortality in the PREDIMED study. Eur J Nutr. 2016 Feb;55(1):227-36. doi: 10.1007/s00394-015-0840-2.
dc.identifier.issn 1436-6207
dc.identifier.uri http://hdl.handle.net/10230/25941
dc.description.abstract PURPOSE: The aim of the present study was to assess the association between the dietary total antioxidant capacity, the dietary intake of different antioxidants and mortality in a Mediterranean population at high cardiovascular disease risk. METHODS: A total of 7,447 subjects from the PREDIMED study (multicenter, parallel group, randomized controlled clinical trial), were analyzed treating data as an observational cohort. Different antioxidant vitamin intake and total dietary antioxidant capacity were calculated from a validated 137-item food frequency questionnaire at baseline and updated yearly. Deaths were ascertained through contact with families and general practitioners, review of medical records and consultation of the National Death Index. Cox regression models were fitted to assess the relationship between dietary total antioxidant capacity and mortality. Dietary total antioxidant capacity was estimated using ferric-reducing antioxidant power assays./nRESULTS: A total of 319 deaths were recorded after a median follow-up of 4.3 years. Subjects belonging to the upper quintile of antioxidant capacity were younger, ex-smokers, with high educational level, and more active and had higher alcohol intake. Multivariable-adjusted models revealed no statistically significant difference between total dietary antioxidant capacity and mortality (Q5 vs. Q1 ref HR 0.85; 95 % CI 0.60-1.20) neither for the intake of all the vitamins studied. CONCLUSIONS: No statistically significant association was found between antioxidant capacity and total mortality in elderly subjects at high cardiovascular risk.
dc.description.sponsorship This study was funded by the Spanish Ministry of Health (ISCIII), CIBEROBN, PI1001407, G03/140, RD06/0045 and the Autonomous Government of Catalonia, and Caixa Tarragona (10-1343).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof European Journal of Nutrition. 2016 Feb;55(1):227-36
dc.rights Copyright © 2015, Springer-Verlag. Henríquez-Sánchez P, Sánchez-Villegas A, Ruano-Rodríguez C, Gea A, Lamuela-Raventós RM, Estruch R. et al. Dietary total antioxidant capacity and mortality in the PREDIMED study. Eur J Nutr. 2016 Feb;55(1):227-36. doi: 10.1007/s00394-015-0840-2.
dc.subject.other Antioxidants
dc.subject.other Mortalitat
dc.title Dietary total antioxidant capacity and mortality in the PREDIMED study.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1007/s00394-015-0840-2
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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