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Cardiometabolic risk profiles in patients with impaired fasting glucose and/or hemoglobin A1c 5.7% to 6.4%: evidence for a gradient according to diagnostic criteria: The PREDAPS Study.

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dc.contributor.author Giráldez-García, Carolina
dc.contributor.author Sangrós, Javier
dc.contributor.author Díaz-Redondo, Alicia
dc.contributor.author Franch-Nadal, Josep
dc.contributor.author Serrano, Rosario
dc.contributor.author Díez, Javier
dc.contributor.author Buil-Cosiales, P.
dc.contributor.author García-Soidán, Javier
dc.contributor.author Artola, Sara
dc.contributor.author Ezkurra, Patxi
dc.contributor.author Carrillo, Lourdes
dc.contributor.author Millaruelo, Manuel
dc.contributor.author Seguí, Mateu
dc.contributor.author Martínez-Candela, Juan
dc.contributor.author Muñoz, Pedro
dc.contributor.author Goday Arno, Alberto
dc.contributor.author Regidor, Enrique
dc.contributor.author REDAPS Study Group
dc.date.accessioned 2016-02-01T12:32:47Z
dc.date.available 2016-02-01T12:32:47Z
dc.date.issued 2015
dc.identifier.citation Giráldez-García C, Sangrós FJ, Díaz-Redondo A, Franch-Nadal J, Serrano R, Díez J. et al. Cardiometabolic risk profiles in patients with impaired fasting glucose and/or hemoglobin A1c 5.7% to 6.4%: evidence for a gradient according to diagnostic criteria: The PREDAPS Study. Medicine (Baltimore). 2015 Nov;94(44):e1935. doi: 10.1097/MD.0000000000001935.
dc.identifier.issn 0025-7974
dc.identifier.uri http://hdl.handle.net/10230/25704
dc.description.abstract It has been suggested that the early detection of individuals with prediabetes can help prevent cardiovascular diseases. The purpose of the current study was to examine the cardiometabolic risk profile in patients with prediabetes according to fasting plasma glucose (FPG) and/or hemoglobin A1c (HbA1c) criteria.Cross-sectional analysis from the 2022 patients in the Cohort study in Primary Health Care on the Evolution of Patients with Prediabetes (PREDAPS Study) was developed. Four glycemic status groups were defined based on American Diabetes Association criteria. Information about cardiovascular risk factors-body mass index, waist circumference, blood pressure, cholesterol, triglycerides, uric acid, gamma-glutamyltransferase, glomerular filtration-and metabolic syndrome components were analyzed. Mean values of clinical and biochemical characteristics and frequencies of metabolic syndrome were estimated adjusting by age, sex, educational level, and family history of diabetes.A linear trend (P < 0.001) was observed in most of the cardiovascular risk factors and in all components of metabolic syndrome. Normoglycemic individuals had the best values, individuals with both criteria of prediabetes had the worst, and individuals with only one-HbA1c or FPG-criterion had an intermediate position. Metabolic syndrome was present in 15.0% (95% confidence interval: 12.6-17.4), 59.5% (54.0-64.9), 62.0% (56.0-68.0), and 76.2% (72.8-79.6) of individuals classified in normoglycemia, isolated HbA1c, isolated FPG, and both criteria groups, respectively.In conclusion, individuals with prediabetes, especially those with both criteria, have worse cardiometabolic risk profile than normoglycemic individuals. These results suggest the need to use both criteria in the clinical practice to identify those individuals with the highest cardiovascular risk, in order to offer them special attention with intensive lifestyle intervention programs.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Lippincott, Williams & Wilkins
dc.rights Copyright 2015 Wolters Kluwer Health, Inc. All rights reserved./nThis is an open access article distributed under the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Sistema cardiovascular -- Malalties -- Prevenció
dc.title Cardiometabolic risk profiles in patients with impaired fasting glucose and/or hemoglobin A1c 5.7% to 6.4%: evidence for a gradient according to diagnostic criteria: The PREDAPS Study.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1097/MD.0000000000001935
dc.identifier.doi http://dx.doi.org/10.1097/MD.0000000000001935
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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