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Characterisation and prognosis of undiagnosed chronic obstructive pulmonary disease patients at their first hospitalisation

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dc.contributor.author Balcells Vilarnau, Eva, 1967-
dc.contributor.author Gimeno Santos, Elena, 1980-
dc.contributor.author De Batlle, Jordi
dc.contributor.author Ramon, Maria Antonia
dc.contributor.author Rodríguez, Esther
dc.contributor.author Benet, Marta
dc.contributor.author Ferrer, Jaume
dc.contributor.author Farrero, Eva
dc.contributor.author Ferrer, Antoni-Lluc, 1942-
dc.contributor.author Guerra, Stefano
dc.contributor.author Ferrer, Jaume
dc.contributor.author Sauleda Roig, Jaume
dc.contributor.author Barberà, Joan Albert
dc.contributor.author Agustí, Alvar
dc.contributor.author Rodriguez, Robert, 1968-
dc.contributor.author Gea Guiral, Joaquim
dc.contributor.author Antó i Boqué, Josep Maria
dc.contributor.author García Aymerich, Judith
dc.date.accessioned 2015-12-16T16:03:26Z
dc.date.available 2015-12-16T16:03:26Z
dc.date.issued 2015
dc.identifier.citation Balcells E, Gimeno-Santos E, De Batlle J, Ramon M, Rodríguez E, Benet M et al. Characterisation and prognosis of undiagnosed chronic obstructive pulmonary disease patients at their first hospitalisation. BMC Pulmonary Medicine. 2015;15:4. DOI: 10.1186/1471-2466-15-4
dc.identifier.issn 1471-2466
dc.identifier.uri http://hdl.handle.net/10230/25450
dc.description.abstract Background. Under-diagnosis of COPD is an important unmet medical need. We investigated the characteristics and prognosis of hospitalised patients with undiagnosed COPD./nMethods. The PAC-COPD cohort included 342 COPD patients hospitalised for the first time for an exacerbation of COPD (2004–2006). Patients were extensively characterised using sociodemographic, clinical and functional variables, and the cohort was followed-up through 2008. We defined “undiagnosed COPD” by the absence of any self-reported respiratory disease and regular use of any pharmacological respiratory treatment./nResults. Undiagnosed COPD was present in 34% of patients. They were younger (mean age 66 vs. 68 years, p = 0.03), reported fewer symptoms (mMRC dyspnoea score, 2.1 vs. 2.6, p < 0.01), and had a better health status (SGRQ total score, 29 vs. 40, p < 0.01), milder airflow limitation (FEV1% ref., 59% vs. 49%, p < 0.01), and fewer comorbidities (two or more, 40% vs. 56%, p < 0.01) when compared with patients with an established COPD diagnosis. Three months after hospital discharge, 16% of the undiagnosed COPD patients had stopped smoking (vs. 5%, p = 0.019). During follow-up, annual hospitalisation rates were lower in undiagnosed COPD patients (0.14 vs. 0.25, p < 0.01); however, this difference disappeared after adjustment for severity. Mortality was similar in both groups./nConclusions. Undiagnosed COPD patients have less severe disease and lower risk of re-hospitalisation when compared with hospitalised patients with known COPD.
dc.description.sponsorship The PAC-COPD Study is funded by grants from Fondo de Investigación Sanitaria (FIS PI020541), Ministry of Health, Spain; Agència d’Avaluació de Tecnologia i Recerca Mèdiques (AATRM 035/20/02), Catalonia Government; Spanish Society of Pneumology and Thoracic Surgery (SEPAR 2002/137); Catalan Foundation of Pneumology (FUCAP 2003 Beca Marià Ravà); Red RESPIRA (RTIC C03/11); Red RCESP (RTIC C03/09); Fondo de Investigación Sanitaria (PI052486); Fondo de Investigación Sanitaria (PI052302); Fondo de Investigación Sanitaria (PI060684); Fundació La Marató de TV3 (num. 041110); and Novartis Farmacèutica, Spain. CIBERESP and CIBERES are funded by the Instituto de Salud Carlos III, Ministry of Health, Spain.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher BioMed Central
dc.relation.ispartof BMC Pulmonary Medicine. 2015;15:4
dc.rights © 2015 Balcells et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0
dc.subject.other Pulmons -- Malalties
dc.title Characterisation and prognosis of undiagnosed chronic obstructive pulmonary disease patients at their first hospitalisation
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1186/1471-2466-15-4
dc.subject.keyword Pulmonary disease
dc.subject.keyword Chronic obstructive
dc.subject.keyword Hospitalisation
dc.subject.keyword Cohort studies
dc.subject.keyword Epidemiology
dc.subject.keyword Health services
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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